Genular: Defining Cellular Identity and Function

Details for: Vim

Gene ID: 22352

Symbol: Vim

Ensembl ID: ENSMUSG00000026728

Description: vimentin

Associated with

Aggrephagy
(R-MMU-9646399)
Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Autophagy
(R-MMU-9612973)
Caspase-mediated cleavage of cytoskeletal proteins
(R-MMU-264870)
Macroautophagy
(R-MMU-1632852)
Muscle contraction
(R-MMU-397014)
Programmed cell death
(R-MMU-5357801)
Rhobtb1 gtpase cycle
(R-MMU-9013422)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Selective autophagy
(R-MMU-9663891)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Striated muscle contraction
(R-MMU-390522)
Astrocyte development
(GO:0014002)
Axon
(GO:0030424)
Bergmann glial cell differentiation
(GO:0060020)
Cell body
(GO:0044297)
Cell leading edge
(GO:0031252)
Cell projection
(GO:0042995)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to muramyl dipeptide
(GO:0071225)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Double-stranded rna binding
(GO:0003725)
Identical protein binding
(GO:0042802)
Intermediate filament
(GO:0005882)
Intermediate filament-based process
(GO:0045103)
Intermediate filament cytoskeleton
(GO:0045111)
Intermediate filament organization
(GO:0045109)
Keratin filament binding
(GO:1990254)
Kinase binding
(GO:0019900)
Lens fiber cell development
(GO:0070307)
Membrane
(GO:0016020)
Molecular adaptor activity
(GO:0060090)
Negative regulation of neuron projection development
(GO:0010977)
Neuron projection
(GO:0043005)
Neuron projection development
(GO:0031175)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisome
(GO:0005777)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glial cell proliferation
(GO:0060252)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein phosphatase 2a binding
(GO:0051721)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of axonogenesis
(GO:0050770)
Regulation of mrna stability
(GO:0043488)
Regulation of schwann cell migration
(GO:1900147)
Rna binding
(GO:0003723)
Scaffold protein binding
(GO:0097110)
Structural constituent of cytoskeleton
(GO:0005200)
Structural constituent of eye lens
(GO:0005212)
Type iii intermediate filament
(GO:0045098)

Other Information

Proteins

Vimentin

Genular Protein ID: 1856298137

Symbol: VIME_MOUSE

Name: Vimentin

UniProtKB Accession Codes:

P20152 O08704 Q8CCH1

Database IDs:

Citations:

PubMed ID: 2744479

Title: Vimentin cDNA clones covering the complete intermediate-filament protein are found in an EHS tumor cDNA library.

PubMed ID: 2744479

DOI: 10.1016/0378-1119(89)90020-6

PubMed ID: 2325630

Title: Coding sequence and flanking regions of the mouse vimentin gene.

PubMed ID: 2325630

DOI: 10.1007/bf00280364

PubMed ID: 2140597

Title: Mouse vimentin: structural relationship to fos, jun, CREB and tpr.

PubMed ID: 2140597

PubMed ID: 8543176

Title: Transcriptional regulation of the vimentin-encoding gene in mouse myeloid leukemia M1 cells.

PubMed ID: 8543176

DOI: 10.1016/0378-1119(95)00600-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2500966

Title: Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure.

PubMed ID: 2500966

DOI: 10.1021/bi00433a035

PubMed ID: 7523108

Title: Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.

PubMed ID: 7523108

DOI: 10.1002/elps.11501501101

PubMed ID: 1850997

Title: Evidence that Ser-82 is a unique phosphorylation site on vimentin for Ca2(+)-calmodulin-dependent protein kinase II.

PubMed ID: 1850997

DOI: 10.1016/0006-291x(91)91658-y

PubMed ID: 9565595

Title: Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis.

PubMed ID: 9565595

DOI: 10.1074/jbc.273.19.11728

PubMed ID: 15128297

Title: Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin.

PubMed ID: 15128297

DOI: 10.1111/j.1432-1033.2004.04095.x

PubMed ID: 15037121

Title: Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton.

PubMed ID: 15037121

DOI: 10.1016/j.exer.2003.09.028

PubMed ID: 14985306

Title: Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse.

PubMed ID: 14985306

DOI: 10.1167/iovs.03-0677

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17356066

Title: Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks.

PubMed ID: 17356066

DOI: 10.1242/jcs.03423

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18178558

Title: A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens.

PubMed ID: 18178558

DOI: 10.1074/jbc.m709144200

PubMed ID: 18827015

Title: TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

PubMed ID: 18827015

DOI: 10.1242/jcs.029454

PubMed ID: 19267394

Title: Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex.

PubMed ID: 19267394

DOI: 10.1002/humu.20981

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19029034

Title: Periplakin interactions with lens intermediate and beaded filaments.

PubMed ID: 19029034

DOI: 10.1167/iovs.08-2894

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21745462

Title: Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.

PubMed ID: 21745462

DOI: 10.1016/j.ydbio.2011.06.036

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 27178841

Title: Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments.

PubMed ID: 27178841

DOI: 10.1016/j.ejcb.2016.04.004

PubMed ID: 27559293

Title: Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium.

PubMed ID: 27559293

Sequence Information:

Length: 466
Mass: 53688
Checksum: A94EECEA6D70C899
Sequence:

MSTRSVSSSS YRRMFGGSGT SSRPSSNRSY VTTSTRTYSL GSALRPSTSR SLYSSSPGGA 
YVTRSSAVRL RSSVPGVRLL QDSVDFSLAD AINTEFKNTR TNEKVELQEL NDRFANYIDK 
VRFLEQQNKI LLAELEQLKG QGKSRLGDLY EEEMRELRRQ VDQLTNDKAR VEVERDNLAE 
DIMRLREKLQ EEMLQREEAE STLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHDE 
EIQELQAQIQ EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE 
AANRNNDALR QAKQESNEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN FALEAANYQD 
TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY RKLLEGEESR ISLPLPTFSS 
LNLRETNLES LPLVDTHSKR TLLIKTVETR DGQVINETSQ HHDDLE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vim

Associated with

Other Information

Vimentin cDNA clones covering the complete intermediate-filament protein are found in an EHS tumor cDNA library. PubMed ID: 2744479

Coding sequence and flanking regions of the mouse vimentin gene. PubMed ID: 2325630

Mouse vimentin: structural relationship to fos, jun, CREB and tpr. PubMed ID: 2140597

Transcriptional regulation of the vimentin-encoding gene in mouse myeloid leukemia M1 cells. PubMed ID: 8543176

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure. PubMed ID: 2500966

Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. PubMed ID: 7523108

Evidence that Ser-82 is a unique phosphorylation site on vimentin for Ca2(+)-calmodulin-dependent protein kinase II. PubMed ID: 1850997

Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. PubMed ID: 9565595

Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin. PubMed ID: 15128297

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. PubMed ID: 15037121

Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse. PubMed ID: 14985306

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. PubMed ID: 17356066

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens. PubMed ID: 18178558

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. PubMed ID: 18827015

Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex. PubMed ID: 19267394

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Periplakin interactions with lens intermediate and beaded filaments. PubMed ID: 19029034

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers. PubMed ID: 21745462

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure. PubMed ID: 24940650

Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments. PubMed ID: 27178841

Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium. PubMed ID: 27559293