Genular: Defining Cellular Identity and Function

Details for: Was

Gene ID: 22376

Symbol: Was

Ensembl ID: ENSMUSG00000031165

Description: Wiskott-Aldrich syndrome

Associated with

Actin binding
(GO:0003779)
Actin filament
(GO:0005884)
Actin filament-based movement
(GO:0030048)
Actin filament organization
(GO:0007015)
Actin filament polymerization
(GO:0030041)
Actin polymerization or depolymerization
(GO:0008154)
Cdc42 protein signal transduction
(GO:0032488)
Cell-cell junction
(GO:0005911)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endosomal transport
(GO:0016197)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of stress fiber assembly
(GO:0051497)
Nucleus
(GO:0005634)
Phagocytic vesicle
(GO:0045335)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of actin polymerization or depolymerization
(GO:0008064)
Regulation of lamellipodium assembly
(GO:0010591)
Regulation of stress fiber assembly
(GO:0051492)
Regulation of t cell antigen processing and presentation
(GO:0002625)
Sh3 domain binding
(GO:0017124)
Site of double-strand break
(GO:0035861)
Small gtpase binding
(GO:0031267)
T cell activation
(GO:0042110)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

Wiskott-Aldrich syndrome protein homolog

Genular Protein ID: 3739450651

Symbol: WASP_MOUSE

Name: Wiskott-Aldrich syndrome protein homolog

UniProtKB Accession Codes:

P70315

Database IDs:

Citations:

PubMed ID: 8666397

Title: The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome.

PubMed ID: 8666397

DOI: 10.1006/geno.1995.9979

PubMed ID: 8910519

Title: Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.

PubMed ID: 8910519

DOI: 10.1074/jbc.271.46.28772

PubMed ID: 9488710

Title: Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein.

PubMed ID: 9488710

DOI: 10.1074/jbc.273.10.5765

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23437151

Title: FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.

PubMed ID: 23437151

DOI: 10.1371/journal.pone.0056516

Sequence Information:

Length: 520
Mass: 54192
Checksum: 9C223733C59F0C8A
Sequence:

MNSGPGPVGG RPGGRGGPAV QQNIPSNLLQ DHENQRLFEL LGRKCWTLAT TVVQLYLALP 
PGAEHWTMEH CGAVCFVKDN PQKSYFIRLY GLQAGRLLWE QELYSQLVYL TPTPFFHTFA 
GDDCQVGLNF ADESEAQAFR ALVQEKIQKR NQRQSGERRQ LPPPPAPINE ERRGGLPPVP 
PHPGGDHGGP SGGPLSLGLV TVDIQNPDIT SSRYRGLPAP GPGPTDKKRS GKKKISKADI 
GAPSGFKHVS HVGWDPQNGF DVNNLDPDLR SLFSRAGISE AQLTDAETSK LIYDFIEDQG 
GLEAVRQEMR RQEPLPPPPP PCRGGGGGGG GGGGGGGGGG GQPLRPPVVG SNKGRSGPLP 
PVPMGGAPPP PTPRGPPPPG RGGPPPPPPP ATGRSGPPPP PLPGAGGPPA PPPPPPPPPP 
PPCPGSGPAP PPLPPTPVSG GSPAPGGGRG ALLDQIRQGI QLNKTPGALE NSVQQPPAQQ 
SEGLVGALMH VMQKRSRVIH SSDEGEDQTG EDEEDDEWDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Was

Associated with

Other Information

The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome. PubMed ID: 8666397

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. PubMed ID: 8910519

Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein. PubMed ID: 9488710

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. PubMed ID: 23437151