Genular: Defining Cellular Identity and Function

Details for: Wdr1

Gene ID: 22388

Symbol: Wdr1

Ensembl ID: ENSMUSG00000005103

Description: WD repeat domain 1

Associated with

Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Actin filament depolymerization
(GO:0030042)
Actin filament fragmentation
(GO:0030043)
Anchoring junction
(GO:0070161)
Apical junction assembly
(GO:0043297)
Cell-cell junction
(GO:0005911)
Cell junction
(GO:0030054)
Cell projection
(GO:0042995)
Cortical actin cytoskeleton
(GO:0030864)
Cortical cytoskeleton organization
(GO:0030865)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Establishment of planar polarity of follicular epithelium
(GO:0042247)
Locomotion
(GO:0040011)
Maintenance of epithelial cell apical/basal polarity
(GO:0045199)
Myelin sheath
(GO:0043209)
Neutrophil mediated immunity
(GO:0002446)
Neutrophil migration
(GO:1990266)
Plasma membrane
(GO:0005886)
Platelet formation
(GO:0030220)
Positive regulation of actin filament depolymerization
(GO:0030836)
Regulation of actin filament depolymerization
(GO:0030834)
Regulation of cell shape
(GO:0008360)
Regulation of oligodendrocyte differentiation
(GO:0048713)
Regulation of ventricular cardiac muscle cell membrane repolarization
(GO:0060307)
Sarcomere organization
(GO:0045214)
Sensory perception of sound
(GO:0007605)

Other Information

Proteins

WD repeat-containing protein 1

Genular Protein ID: 2494055611

Symbol: WDR1_MOUSE

Name: WD repeat-containing protein 1

UniProtKB Accession Codes:

O88342

Database IDs:

Citations:

PubMed ID: 10036186

Title: A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein.

PubMed ID: 10036186

DOI: 10.1006/geno.1998.5672

PubMed ID: 17515402

Title: Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia.

PubMed ID: 17515402

DOI: 10.1182/blood-2006-10-055087

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24840128

Title: A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.

PubMed ID: 24840128

DOI: 10.1016/j.ajpath.2014.04.007

PubMed ID: 25915128

Title: Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.

PubMed ID: 25915128

DOI: 10.1038/ncb3146

Sequence Information:

Length: 606
Mass: 66407
Checksum: 573CEA1DCD7CA80E
Sequence:

MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI ADIYTEHAHQ 
VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 
GEGREKFGAV FLWDTGSSVG EITGHNKVIN SVDIKQTRPY RLATGSDDNC AAFFEGPPFK 
FKFTIGDHSR FVNCVRFSPD GNRFATASAD GQIFIYDGKT GEKVCALGES KAHDGGIYAI 
SWSPDSTHLL SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY 
INYLDKNNPS KPLRVIKGHS KSIQCLTVHR NGGKSYIYSG SHDGHINYWD SETGENDSFS 
GKGHTNQVSR MTVNESEQLV SCSMDDTVRY TNLTLRDYSG QGVVKLDVQP KCVAVGPGGY 
TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV VAVHPGGDTV AVGGTDGNVR VYSILASTLK 
DEGKLLEAKG PVTDVAYSHD GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW 
SPDNEHFASG GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK 
EWTITY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wdr1

Associated with

Other Information

A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. PubMed ID: 10036186

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. PubMed ID: 17515402

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. PubMed ID: 24840128

Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity. PubMed ID: 25915128