Details for: ALDH3A2

Gene ID: 224

Symbol: ALDH3A2

Ensembl ID: ENSG00000072210

Description: aldehyde dehydrogenase 3 family member A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.85
    Marker Score: 86026
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.52
    Marker Score: 18789
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.39
    Marker Score: 2703
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.23
    Marker Score: 2347.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.12
    Marker Score: 1418
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.11
    Marker Score: 2975
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.07
    Marker Score: 2494
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.06
    Marker Score: 17748
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.86
    Marker Score: 1934
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.85
    Marker Score: 6563
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.84
    Marker Score: 537
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.77
    Marker Score: 11291
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1859
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.67
    Marker Score: 15859
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.65
    Marker Score: 961
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.62
    Marker Score: 2088
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.6
    Marker Score: 12508
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167319
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2240
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12273
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.43
    Marker Score: 6855
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.42
    Marker Score: 1260
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.41
    Marker Score: 86613
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.4
    Marker Score: 404
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.39
    Marker Score: 4791
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.36
    Marker Score: 634.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.34
    Marker Score: 6584.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.31
    Marker Score: 2986
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.31
    Marker Score: 1812
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.29
    Marker Score: 751
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.29
    Marker Score: 4992
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.28
    Marker Score: 6708
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.26
    Marker Score: 2637
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.25
    Marker Score: 4085
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.24
    Marker Score: 3025
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2886
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.22
    Marker Score: 546
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.2
    Marker Score: 2847
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45480
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.19
    Marker Score: 10357
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.18
    Marker Score: 2682
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.17
    Marker Score: 1239
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.17
    Marker Score: 781
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11807
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.14
    Marker Score: 1158
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.14
    Marker Score: 1811.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.13
    Marker Score: 3228
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.12
    Marker Score: 953
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.08
    Marker Score: 2902
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.08
    Marker Score: 343
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.08
    Marker Score: 4387.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.08
    Marker Score: 1966
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.07
    Marker Score: 3368
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.07
    Marker Score: 1758.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.06
    Marker Score: 17080
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.06
    Marker Score: 27194
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.06
    Marker Score: 4099
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.04
    Marker Score: 259
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.04
    Marker Score: 1216
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.04
    Marker Score: 388.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.04
    Marker Score: 867
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.03
    Marker Score: 1743
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.02
    Marker Score: 2577
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.02
    Marker Score: 20253
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7776
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.01
    Marker Score: 1451
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1
    Marker Score: 2722
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71696
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47921
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.99
    Marker Score: 239
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.98
    Marker Score: 428
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15284
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.98
    Marker Score: 2060
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.97
    Marker Score: 3575
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.95
    Marker Score: 6135
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.95
    Marker Score: 223
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.95
    Marker Score: 1007
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.95
    Marker Score: 467
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.94
    Marker Score: 216
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.93
    Marker Score: 1004
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.92
    Marker Score: 33974
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 627
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.92
    Marker Score: 1353
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5233
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.91
    Marker Score: 31643
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.88
    Marker Score: 543
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.88
    Marker Score: 8861
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1422
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.87
    Marker Score: 5689
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.87
    Marker Score: 3751
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.85
    Marker Score: 357
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.84
    Marker Score: 1355
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.84
    Marker Score: 315

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Other Information

**Key characteristics:** * The ALDH3A2 gene is located on chromosome 17q21.1. * It is a large gene, encoding for a protein of approximately 1.3 MB. * The protein is expressed in a variety of tissues, including the adrenal gland, trachea, tracheobronchial tree, conjunctiva, nasal mucosa, esophagus, pancreatic duct, and proximal tubule. **Pathways and functions:** * The ALDH3A2 gene is involved in a variety of pathways, including the detoxification of aldehydes, the metabolism of lipids, and the regulation of the immune response. * It is involved in the metabolism of fatty acids, including the synthesis of ceramide, which is a precursor to sphingolipids. * It is also involved in the regulation of the immune response, by detoxifying reactive aldehydes produced by activated immune cells. **Clinical significance:** * Mutations in the ALDH3A2 gene have been linked to a number of human diseases, including liver disease, kidney disease, and cancer. * These mutations can lead to the accumulation of aldehydes in the body, which can damage tissues and organs. * Research on ALDH3A2 is therefore an important area of research, with the potential to lead to the development of new treatments for these diseases.

Genular Protein ID: 2017178677

Symbol: AL3A2_HUMAN

Name: Aldehyde dehydrogenase family 3 member A2

UniProtKB Accession Codes:

P51648 Q6I9T3 Q93011 Q96J37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 79 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 27 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 6 Rhea 13 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8528251

Title: Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.

PubMed ID: 8528251

DOI: 10.1038/ng0196-52

PubMed ID: 9027499

Title: Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).

PubMed ID: 9027499

DOI: 10.1006/geno.1996.4501

PubMed ID: 9070922

Title: Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression.

PubMed ID: 9070922

DOI: 10.1006/geno.1996.4547

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9133646

Title: Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization.

PubMed ID: 9133646

DOI: 10.1016/s0304-4165(96)00126-2

PubMed ID: 9662422

Title: Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid.

PubMed ID: 9662422

DOI: 10.1016/s0014-5793(98)00574-2

PubMed ID: 18035827

Title: Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjoegren-Larsson syndrome.

PubMed ID: 18035827

DOI: 10.1080/14756360701425360

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25047030

Title: A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

PubMed ID: 25047030

DOI: 10.1038/ncomms5439

PubMed ID: 9254849

Title: A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden.

PubMed ID: 9254849

DOI: 10.1007/s004390050490

PubMed ID: 9829906

Title: Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjoegren-Larsson syndrome.

PubMed ID: 9829906

DOI: 10.1002/(sici)1098-1004(1998)12:6<377::aid-humu3>3.0.co;2-i

PubMed ID: 10577908

Title: The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene.

PubMed ID: 10577908

DOI: 10.1086/302681

PubMed ID: 10792573

Title: A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome.

PubMed ID: 10792573

DOI: 10.1046/j.1523-1747.2000.00960-5.x

Sequence Information:

  • Length: 485
  • Mass: 54848
  • Checksum: 209601CB5803C7E3
  • Sequence:
    • MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE 
VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ 
PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH 
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 
CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 
AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA 
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV 
KAEYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.