Details for: ALDH3A2

Gene ID: 224

Symbol: ALDH3A2

Ensembl ID: ENSG00000072210

Description: aldehyde dehydrogenase 3 family member A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.0179
    Cell Significance Index: -42.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.5798
    Cell Significance Index: -40.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.8970
    Cell Significance Index: -32.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.0884
    Cell Significance Index: -38.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.3705
    Cell Significance Index: -32.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.3200
    Cell Significance Index: -42.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5659
    Cell Significance Index: -39.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1799
    Cell Significance Index: -37.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7652
    Cell Significance Index: -42.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.2022
    Cell Significance Index: 219.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7036
    Cell Significance Index: -16.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.9038
    Cell Significance Index: 80.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 5.2713
    Cell Significance Index: 80.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.7504
    Cell Significance Index: 104.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8390
    Cell Significance Index: 813.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7416
    Cell Significance Index: 123.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4796
    Cell Significance Index: 56.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4624
    Cell Significance Index: 64.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4133
    Cell Significance Index: 280.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3463
    Cell Significance Index: 36.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3358
    Cell Significance Index: 923.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0449
    Cell Significance Index: 209.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8627
    Cell Significance Index: 58.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7831
    Cell Significance Index: 36.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7541
    Cell Significance Index: 1.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7455
    Cell Significance Index: 51.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7449
    Cell Significance Index: 672.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6736
    Cell Significance Index: 82.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5485
    Cell Significance Index: 98.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5367
    Cell Significance Index: 9.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5236
    Cell Significance Index: 285.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4922
    Cell Significance Index: 176.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4802
    Cell Significance Index: 47.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3444
    Cell Significance Index: 8.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2675
    Cell Significance Index: 30.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2507
    Cell Significance Index: 159.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2276
    Cell Significance Index: 3.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2153
    Cell Significance Index: 16.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2089
    Cell Significance Index: 35.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1992
    Cell Significance Index: 9.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1882
    Cell Significance Index: 25.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1597
    Cell Significance Index: 20.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1578
    Cell Significance Index: 3.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1395
    Cell Significance Index: 87.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0927
    Cell Significance Index: 17.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0912
    Cell Significance Index: 3.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0711
    Cell Significance Index: 2.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0279
    Cell Significance Index: 51.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0274
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0215
    Cell Significance Index: 40.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0186
    Cell Significance Index: 13.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0158
    Cell Significance Index: -0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0287
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0299
    Cell Significance Index: -22.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0369
    Cell Significance Index: -1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0383
    Cell Significance Index: -2.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0531
    Cell Significance Index: -7.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0541
    Cell Significance Index: -5.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0542
    Cell Significance Index: -30.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0690
    Cell Significance Index: -11.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0806
    Cell Significance Index: -9.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1225
    Cell Significance Index: -35.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1281
    Cell Significance Index: -26.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1619
    Cell Significance Index: -17.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1846
    Cell Significance Index: -21.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1996
    Cell Significance Index: -12.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2268
    Cell Significance Index: -26.7500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2325
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2333
    Cell Significance Index: -18.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2347
    Cell Significance Index: -17.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2376
    Cell Significance Index: -30.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2799
    Cell Significance Index: -18.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3304
    Cell Significance Index: -5.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3315
    Cell Significance Index: -18.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3343
    Cell Significance Index: -8.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3580
    Cell Significance Index: -10.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3643
    Cell Significance Index: -17.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3908
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3944
    Cell Significance Index: -41.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4143
    Cell Significance Index: -8.9800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.4261
    Cell Significance Index: -3.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5181
    Cell Significance Index: -27.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5552
    Cell Significance Index: -34.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5582
    Cell Significance Index: -15.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6586
    Cell Significance Index: -21.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6684
    Cell Significance Index: -9.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6973
    Cell Significance Index: -11.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7512
    Cell Significance Index: -23.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8107
    Cell Significance Index: -29.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8419
    Cell Significance Index: -19.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8699
    Cell Significance Index: -28.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8722
    Cell Significance Index: -25.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8757
    Cell Significance Index: -22.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9038
    Cell Significance Index: -19.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9103
    Cell Significance Index: -31.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9330
    Cell Significance Index: -14.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic Activity**: ALDH3A2 is a long-chain-aldehyde dehydrogenase that catalyzes the oxidation of long-chain aldehydes to their corresponding carboxylic acids, thereby playing a crucial role in the metabolism of lipids and fatty acids. 2. **Tissue Expression**: The ALDH3A2 gene is highly expressed in tissues such as the adrenal gland, trachea, and epithelial cells of the esophagus, indicating its importance in various cellular processes. 3. **Subcellular Localization**: ALDH3A2 is localized to the endoplasmic reticulum membrane and peroxisomes, suggesting its involvement in lipid metabolism and detoxification processes. 4. **Regulatory Mechanisms**: The expression and activity of ALDH3A2 are regulated by various signaling pathways, including the Rho GTPase cycle, which is involved in cell migration, adhesion, and proliferation. **Pathways and Functions** 1. **Peroxisomal Lipid Metabolism**: ALDH3A2 plays a crucial role in the metabolism of long-chain aldehydes, which are produced during the oxidation of fatty acids and other lipids. This process involves the conversion of long-chain aldehydes to their corresponding carboxylic acids, which are then further metabolized or excreted. 2. **Central Nervous System Development**: ALDH3A2 is involved in the development of the central nervous system, particularly in the differentiation and maturation of neurons and glial cells. 3. **Cellular Aldehyde Metabolic Process**: ALDH3A2 is also involved in the metabolism of aldehydes, which are toxic compounds that can cause cellular damage if not properly metabolized. 4. **Fatty Acid Metabolism**: ALDH3A2 plays a role in the metabolism of fatty acids, which are essential for energy production and cellular growth. **Clinical Significance** 1. **Alzheimer's Disease**: Defects in ALDH3A2 have been associated with Alzheimer's disease, a neurodegenerative disorder characterized by cognitive decline and memory loss. 2. **Cancer**: ALDH3A2 is overexpressed in various types of cancer, including lung, breast, and colon cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurodevelopmental Disorders**: ALDH3A2 is involved in the development of the central nervous system, and defects in this gene have been associated with neurodevelopmental disorders such as autism and schizophrenia. 4. **Metabolic Disorders**: ALDH3A2 plays a role in lipid metabolism, and defects in this gene have been associated with metabolic disorders such as obesity and fatty liver disease. In conclusion, the ALDH3A2 gene is a crucial enzyme involved in various metabolic processes within the cell, including lipid metabolism, fatty acid metabolism, and cellular aldehyde metabolism. Its dysregulation has been associated with various diseases, including Alzheimer's disease, cancer, neurodevelopmental disorders, and metabolic disorders. Further research is needed to fully understand the role of ALDH3A2 in human health and disease.

Genular Protein ID: 2017178677

Symbol: AL3A2_HUMAN

Name: Aldehyde dehydrogenase family 3 member A2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8528251

Title: Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.

PubMed ID: 8528251

DOI: 10.1038/ng0196-52

PubMed ID: 9027499

Title: Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).

PubMed ID: 9027499

DOI: 10.1006/geno.1996.4501

PubMed ID: 9070922

Title: Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression.

PubMed ID: 9070922

DOI: 10.1006/geno.1996.4547

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9133646

Title: Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization.

PubMed ID: 9133646

DOI: 10.1016/s0304-4165(96)00126-2

PubMed ID: 9662422

Title: Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid.

PubMed ID: 9662422

DOI: 10.1016/s0014-5793(98)00574-2

PubMed ID: 18035827

Title: Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjoegren-Larsson syndrome.

PubMed ID: 18035827

DOI: 10.1080/14756360701425360

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22633490

Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

PubMed ID: 22633490

DOI: 10.1016/j.molcel.2012.04.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25047030

Title: A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

PubMed ID: 25047030

DOI: 10.1038/ncomms5439

PubMed ID: 9254849

Title: A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden.

PubMed ID: 9254849

DOI: 10.1007/s004390050490

PubMed ID: 9829906

Title: Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjoegren-Larsson syndrome.

PubMed ID: 9829906

DOI: 10.1002/(sici)1098-1004(1998)12:6<377::aid-humu3>3.0.co;2-i

PubMed ID: 10577908

Title: The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene.

PubMed ID: 10577908

DOI: 10.1086/302681

PubMed ID: 10792573

Title: A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome.

PubMed ID: 10792573

DOI: 10.1046/j.1523-1747.2000.00960-5.x

Sequence Information:

  • Length: 485
  • Mass: 54848
  • Checksum: 209601CB5803C7E3
  • Sequence:
  • MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE 
    VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ 
    PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH 
    IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 
    CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 
    AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA 
    LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 
    HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV 
    KAEYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.