Details for: ALDH3A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 270.0179
Cell Significance Index: -42.0000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 160.5798
Cell Significance Index: -40.7300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 80.8970
Cell Significance Index: -32.8700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 74.0884
Cell Significance Index: -38.1100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 34.3705
Cell Significance Index: -32.8200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.3200
Cell Significance Index: -42.3200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.5659
Cell Significance Index: -39.0200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.1799
Cell Significance Index: -37.4100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.7652
Cell Significance Index: -42.4800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 8.2022
Cell Significance Index: 219.7800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.7036
Cell Significance Index: -16.8600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 5.9038
Cell Significance Index: 80.5500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 5.2713
Cell Significance Index: 80.0600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.7504
Cell Significance Index: 104.8100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.8390
Cell Significance Index: 813.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.7416
Cell Significance Index: 123.1700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.4796
Cell Significance Index: 56.0300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.4624
Cell Significance Index: 64.6900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4133
Cell Significance Index: 280.4800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3463
Cell Significance Index: 36.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3358
Cell Significance Index: 923.8800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0449
Cell Significance Index: 209.6000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8627
Cell Significance Index: 58.0100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7831
Cell Significance Index: 36.5100 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.7541
Cell Significance Index: 1.7000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7455
Cell Significance Index: 51.5600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7449
Cell Significance Index: 672.5600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6736
Cell Significance Index: 82.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5485
Cell Significance Index: 98.8800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.5367
Cell Significance Index: 9.0400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5236
Cell Significance Index: 285.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4922
Cell Significance Index: 176.5500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4802
Cell Significance Index: 47.5000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3444
Cell Significance Index: 8.6100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2675
Cell Significance Index: 30.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2507
Cell Significance Index: 159.2400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.2276
Cell Significance Index: 3.2400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2153
Cell Significance Index: 16.5200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2089
Cell Significance Index: 35.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1992
Cell Significance Index: 9.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1882
Cell Significance Index: 25.8400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1597
Cell Significance Index: 20.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1578
Cell Significance Index: 3.3600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.1395
Cell Significance Index: 87.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0927
Cell Significance Index: 17.6400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0912
Cell Significance Index: 3.1700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0711
Cell Significance Index: 2.5000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0279
Cell Significance Index: 51.4300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0274
Cell Significance Index: 0.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0215
Cell Significance Index: 40.5300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0186
Cell Significance Index: 13.6700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0053
Cell Significance Index: -8.2100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0139
Cell Significance Index: -10.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0158
Cell Significance Index: -0.8300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0200
Cell Significance Index: -27.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0287
Cell Significance Index: -1.4900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0299
Cell Significance Index: -22.1500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0369
Cell Significance Index: -1.8600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0383
Cell Significance Index: -2.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0386
Cell Significance Index: -17.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0531
Cell Significance Index: -7.7200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0541
Cell Significance Index: -5.5300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0542
Cell Significance Index: -30.5700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0690
Cell Significance Index: -11.2200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0806
Cell Significance Index: -9.2400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1225
Cell Significance Index: -35.2400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1281
Cell Significance Index: -26.9900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1619
Cell Significance Index: -17.6100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1846
Cell Significance Index: -21.5100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1996
Cell Significance Index: -12.5800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2268
Cell Significance Index: -26.7500 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.2325
Cell Significance Index: -2.4700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2333
Cell Significance Index: -18.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2347
Cell Significance Index: -17.4900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2376
Cell Significance Index: -30.6900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2799
Cell Significance Index: -18.0600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3304
Cell Significance Index: -5.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3315
Cell Significance Index: -18.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3343
Cell Significance Index: -8.7900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3580
Cell Significance Index: -10.3200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3643
Cell Significance Index: -17.1200 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.3908
Cell Significance Index: -3.1200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3944
Cell Significance Index: -41.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4143
Cell Significance Index: -8.9800 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.4261
Cell Significance Index: -3.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5181
Cell Significance Index: -27.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5552
Cell Significance Index: -34.0400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5582
Cell Significance Index: -15.9300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6586
Cell Significance Index: -21.1000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6684
Cell Significance Index: -9.8700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6973
Cell Significance Index: -11.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7512
Cell Significance Index: -23.9300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8107
Cell Significance Index: -29.7600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.8419
Cell Significance Index: -19.4500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8699
Cell Significance Index: -28.4800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8722
Cell Significance Index: -25.6900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8757
Cell Significance Index: -22.5100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.9038
Cell Significance Index: -19.7900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9103
Cell Significance Index: -31.8900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.9330
Cell Significance Index: -14.0600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2017178677
Symbol: AL3A2_HUMAN
Name: Aldehyde dehydrogenase family 3 member A2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8528251
Title: Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.
PubMed ID: 8528251
DOI: 10.1038/ng0196-52
PubMed ID: 9027499
Title: Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).
PubMed ID: 9027499
PubMed ID: 9070922
Title: Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression.
PubMed ID: 9070922
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9133646
Title: Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization.
PubMed ID: 9133646
PubMed ID: 9662422
Title: Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid.
PubMed ID: 9662422
PubMed ID: 18035827
Title: Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjoegren-Larsson syndrome.
PubMed ID: 18035827
PubMed ID: 18182499
Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
PubMed ID: 18182499
DOI: 10.1096/fj.07-099150
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22633490
Title: The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
PubMed ID: 22633490
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25047030
Title: A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.
PubMed ID: 25047030
DOI: 10.1038/ncomms5439
PubMed ID: 9254849
Title: A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden.
PubMed ID: 9254849
PubMed ID: 9829906
Title: Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjoegren-Larsson syndrome.
PubMed ID: 9829906
DOI: 10.1002/(sici)1098-1004(1998)12:6<377::aid-humu3>3.0.co;2-i
PubMed ID: 10577908
Title: The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene.
PubMed ID: 10577908
DOI: 10.1086/302681
PubMed ID: 10792573
Title: A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome.
PubMed ID: 10792573
Sequence Information:
- Length: 485
- Mass: 54848
- Checksum: 209601CB5803C7E3
- Sequence:
MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV KAEYY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.