Genular: Defining Cellular Identity and Function

Details for: Wnt1

Gene ID: 22408

Symbol: Wnt1

Ensembl ID: ENSMUSG00000022997

Description: wingless-type MMTV integration site family, member 1

Associated with

Beta-catenin independent wnt signaling
(R-MMU-3858494)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Pcp/ce pathway
(R-MMU-4086400)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Animal organ morphogenesis
(GO:0009887)
Animal organ regeneration
(GO:0031100)
Bmp signaling pathway
(GO:0030509)
Bone development
(GO:0060348)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Canonical wnt signaling pathway
(GO:0060070)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Cell population proliferation
(GO:0008283)
Cell proliferation in midbrain
(GO:0033278)
Cell surface
(GO:0009986)
Central nervous system morphogenesis
(GO:0021551)
Cerebellum development
(GO:0021549)
Cerebellum formation
(GO:0021588)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Diencephalon development
(GO:0021536)
Dopaminergic neuron differentiation
(GO:0071542)
Embryonic axis specification
(GO:0000578)
Embryonic brain development
(GO:1990403)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fat cell differentiation
(GO:0045444)
Forebrain anterior/posterior pattern specification
(GO:0021797)
Frizzled binding
(GO:0005109)
Hematopoietic stem cell proliferation
(GO:0071425)
Hepatocyte differentiation
(GO:0070365)
Inner ear morphogenesis
(GO:0042472)
Metencephalon development
(GO:0022037)
Midbrain-hindbrain boundary development
(GO:0030917)
Midbrain-hindbrain boundary maturation during brain development
(GO:0022004)
Midbrain development
(GO:0030901)
Midbrain dopaminergic neuron differentiation
(GO:1904948)
Multicellular organism development
(GO:0007275)
Myoblast fusion
(GO:0007520)
Myotube differentiation
(GO:0014902)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903377)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Neuron fate commitment
(GO:0048663)
Neuron fate determination
(GO:0048664)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dermatome development
(GO:0061184)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of hematopoietic stem cell proliferation
(GO:1902035)
Positive regulation of insulin-like growth factor receptor signaling pathway
(GO:0043568)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Receptor ligand activity
(GO:0048018)
Regulation of dna-templated transcription
(GO:0006355)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Signal transduction in response to dna damage
(GO:0042770)
Spemann organizer formation
(GO:0060061)
Spinal cord association neuron differentiation
(GO:0021527)
T cell differentiation in thymus
(GO:0033077)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Proto-oncogene Wnt-1

Genular Protein ID: 1136332274

Symbol: WNT1_MOUSE

Name: Proto-oncogene Wnt-1

UniProtKB Accession Codes:

P04426

Database IDs:

Citations:

PubMed ID: 6091914

Title: Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact.

PubMed ID: 6091914

DOI: 10.1016/0092-8674(84)90209-5

PubMed ID: 3018519

Title: Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.

PubMed ID: 3018519

DOI: 10.1128/mcb.5.12.3337-3344.1985

PubMed ID: 2279700

Title: Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

PubMed ID: 2279700

DOI: 10.1101/gad.4.12b.2319

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2202907

Title: Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

PubMed ID: 2202907

DOI: 10.1038/346847a0

PubMed ID: 3594565

Title: Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo.

PubMed ID: 3594565

DOI: 10.1016/0092-8674(87)90664-7

PubMed ID: 3594566

Title: Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos.

PubMed ID: 3594566

DOI: 10.1016/0092-8674(87)90665-9

PubMed ID: 10866835

Title: The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PubMed ID: 10866835

DOI: 10.1046/j.1432-1033.2000.01478.x

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 16116452

Title: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract.

PubMed ID: 16116452

DOI: 10.1038/nn1520

PubMed ID: 16543246

Title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

PubMed ID: 16543246

DOI: 10.1074/jbc.m508324200

PubMed ID: 19841259

Title: Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.

PubMed ID: 19841259

DOI: 10.1073/pnas.0904894106

PubMed ID: 23499309

Title: Mutations in WNT1 cause different forms of bone fragility.

PubMed ID: 23499309

DOI: 10.1016/j.ajhg.2013.02.010

PubMed ID: 23656646

Title: WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.

PubMed ID: 23656646

DOI: 10.1056/nejmoa1215458

Sequence Information:

Length: 370
Mass: 41086
Checksum: 02EEB23109231A40
Sequence:

MGLWALLPSW VSTTLLLALT ALPAALAANS SGRWWGIVNI ASSTNLLTDS KSLQLVLEPS 
LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG 
CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF 
GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR 
AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT 
YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC 
THTRVLHECL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wnt1

Associated with

Other Information

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. PubMed ID: 6091914

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. PubMed ID: 3018519

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. PubMed ID: 2279700

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. PubMed ID: 2202907

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. PubMed ID: 3594565

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. PubMed ID: 3594566

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. PubMed ID: 10866835

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. PubMed ID: 15454084

Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. PubMed ID: 16116452

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. PubMed ID: 16543246

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. PubMed ID: 19841259

Mutations in WNT1 cause different forms of bone fragility. PubMed ID: 23499309

WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. PubMed ID: 23656646