Genular: Defining Cellular Identity and Function

Details for: Wnt3a

Gene ID: 22416

Symbol: Wnt3a

Ensembl ID: ENSMUSG00000009900

Description: wingless-type MMTV integration site family, member 3A

Associated with

Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Animal organ morphogenesis
(GO:0009887)
Anterior/posterior pattern specification
(GO:0009952)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
B cell proliferation
(GO:0042100)
Bmp signaling pathway
(GO:0030509)
Canonical wnt signaling pathway
(GO:0060070)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Cell population proliferation
(GO:0008283)
Cell proliferation in forebrain
(GO:0021846)
Cell proliferation in midbrain
(GO:0033278)
Co-receptor binding
(GO:0039706)
Cop9 signalosome assembly
(GO:0010387)
Cytokine activity
(GO:0005125)
Cytokine production
(GO:0001816)
Determination of left/right symmetry
(GO:0007368)
Dorsal/ventral neural tube patterning
(GO:0021904)
Extracellular matrix organization
(GO:0030198)
Fat cell differentiation
(GO:0045444)
Frizzled binding
(GO:0005109)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Hemopoiesis
(GO:0030097)
Hippocampus development
(GO:0021766)
Identical protein binding
(GO:0042802)
Inner ear morphogenesis
(GO:0042472)
In utero embryonic development
(GO:0001701)
Mammary gland development
(GO:0030879)
Mesoderm development
(GO:0007498)
Midbrain development
(GO:0030901)
Modulation of chemical synaptic transmission
(GO:0050804)
Multicellular organism development
(GO:0007275)
Myoblast differentiation
(GO:0045445)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron projection development
(GO:0010977)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Non-canonical wnt signaling pathway
(GO:0035567)
Osteoblast differentiation
(GO:0001649)
Paraxial mesodermal cell fate commitment
(GO:0048343)
Platelet activation
(GO:0030168)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collateral sprouting in absence of injury
(GO:0048697)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mesodermal cell fate specification
(GO:0048337)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of skeletal muscle tissue development
(GO:0048643)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-anal tail morphogenesis
(GO:0036342)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Receptor ligand activity
(GO:0048018)
Regulation of axonogenesis
(GO:0050770)
Regulation of cell differentiation
(GO:0045595)
Regulation of synapse organization
(GO:0050807)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal muscle cell differentiation
(GO:0035914)
Somatic stem cell division
(GO:0048103)
Somitogenesis
(GO:0001756)
Spinal cord association neuron differentiation
(GO:0021527)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway involved in forebrain neuroblast division
(GO:0021874)

Other Information

Proteins

Protein Wnt-3a

Genular Protein ID: 2723849371

Symbol: WNT3A_MOUSE

Name: Protein Wnt-3a

UniProtKB Accession Codes:

P27467

Database IDs:

Citations:

PubMed ID: 2001840

Title: Expression of two members of the Wnt family during mouse development -- restricted temporal and spatial patterns in the developing neural tube.

PubMed ID: 2001840

DOI: 10.1101/gad.5.3.381

PubMed ID: 8299937

Title: Wnt-3a regulates somite and tailbud formation in the mouse embryo.

PubMed ID: 8299937

DOI: 10.1101/gad.8.2.174

PubMed ID: 10866835

Title: The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PubMed ID: 10866835

DOI: 10.1046/j.1432-1033.2000.01478.x

PubMed ID: 12717451

Title: Wnt proteins are lipid-modified and can act as stem cell growth factors.

PubMed ID: 12717451

DOI: 10.1038/nature01611

PubMed ID: 22726442

Title: Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

PubMed ID: 22726442

DOI: 10.1016/j.cell.2012.04.039

PubMed ID: 17141155

Title: Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.

PubMed ID: 17141155

DOI: 10.1016/j.devcel.2006.10.003

PubMed ID: 24798332

Title: Identification of key residues and regions important for porcupine-mediated Wnt acylation.

PubMed ID: 24798332

DOI: 10.1074/jbc.m114.561209

PubMed ID: 25771893

Title: Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.

PubMed ID: 25771893

DOI: 10.1016/j.devcel.2015.02.014

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

Sequence Information:

Length: 352
Mass: 39258
Checksum: 7ADFC5B38A8EFF63
Sequence:

MAPLGYLLVL CSLKQALGSY PIWWSLAVGP QYSSLSTQPI LCASIPGLVP KQLRFCRNYV 
EIMPSVAEGV KAGIQECQHQ FRGRRWNCTT VSNSLAIFGP VLDKATRESA FVHAIASAGV 
AFAVTRSCAE GSAAICGCSS RLQGSPGEGW KWGGCSEDIE FGGMVSREFA DARENRPDAR 
SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRTIGDF LKDKYDSASE 
MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 
SHGIDGCDLL CCGRGHNART ERRREKCHCV FHWCCYVSCQ ECTRVYDVHT CK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wnt3a

Associated with

Other Information

Expression of two members of the Wnt family during mouse development -- restricted temporal and spatial patterns in the developing neural tube. PubMed ID: 2001840

Wnt-3a regulates somite and tailbud formation in the mouse embryo. PubMed ID: 8299937

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. PubMed ID: 10866835

Wnt proteins are lipid-modified and can act as stem cell growth factors. PubMed ID: 12717451

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. PubMed ID: 22726442

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. PubMed ID: 17141155

Identification of key residues and regions important for porcupine-mediated Wnt acylation. PubMed ID: 24798332

Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation. PubMed ID: 25771893

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin. PubMed ID: 26902720