Genular: Defining Cellular Identity and Function

Details for: Wnt4

Gene ID: 22417

Symbol: Wnt4

Ensembl ID: ENSMUSG00000036856

Description: wingless-type MMTV integration site family, member 4

Associated with

Beta-catenin independent wnt signaling
(R-MMU-3858494)
Pcp/ce pathway
(R-MMU-4086400)
Signaling by wnt
(R-MMU-195721)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Anatomical structure development
(GO:0048856)
Apoptotic signaling pathway
(GO:0097190)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Canonical wnt signaling pathway
(GO:0060070)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cellular response to starvation
(GO:0009267)
Cytokine activity
(GO:0005125)
Embryonic epithelial tube formation
(GO:0001838)
Female gonad development
(GO:0008585)
Female sex determination
(GO:0030237)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Frizzled binding
(GO:0005109)
Gamete generation
(GO:0007276)
Hormone metabolic process
(GO:0042445)
Immature t cell proliferation in thymus
(GO:0033080)
Kidney morphogenesis
(GO:0060993)
Male gonad development
(GO:0008584)
Meiotic nuclear division
(GO:0140013)
Mesenchymal to epithelial transition
(GO:0060231)
Mesonephric tubule development
(GO:0072164)
Mesonephros development
(GO:0001823)
Metanephric mesenchymal cell differentiation
(GO:0072162)
Metanephric nephron development
(GO:0072210)
Metanephric nephron morphogenesis
(GO:0072273)
Metanephric tubule formation
(GO:0072174)
Metanephros development
(GO:0001656)
Multicellular organism development
(GO:0007275)
Negative regulation of androgen biosynthetic process
(GO:2000180)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of male gonad development
(GO:2000019)
Negative regulation of steroid biosynthetic process
(GO:0010894)
Negative regulation of testicular blood vessel morphogenesis
(GO:0061369)
Negative regulation of wound healing
(GO:0061045)
Nephron development
(GO:0072006)
Neuron differentiation
(GO:0030182)
Non-canonical wnt signaling pathway
(GO:0035567)
Oocyte development
(GO:0048599)
Paramesonephric duct development
(GO:0061205)
Pericyte cell differentiation
(GO:1904238)
Positive regulation of aldosterone biosynthetic process
(GO:0032349)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of cortisol biosynthetic process
(GO:2000066)
Positive regulation of dermatome development
(GO:0061184)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of meiotic nuclear division
(GO:0045836)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of stress fiber assembly
(GO:0051496)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of cell-cell adhesion
(GO:0022407)
Renal vesicle formation
(GO:0072033)
Renal vesicle induction
(GO:0072034)
Sertoli cell differentiation
(GO:0060008)
Sex differentiation
(GO:0007548)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Smooth muscle cell differentiation
(GO:0051145)
Somatotropin secreting cell differentiation
(GO:0060126)
T cell differentiation in thymus
(GO:0033077)
Tertiary branching involved in mammary gland duct morphogenesis
(GO:0060748)
Thyroid-stimulating hormone-secreting cell differentiation
(GO:0060129)
Transcription corepressor activity
(GO:0003714)
Tube morphogenesis
(GO:0035239)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Protein Wnt-4

Genular Protein ID: 1272071053

Symbol: WNT4_MOUSE

Name: Protein Wnt-4

UniProtKB Accession Codes:

P22724

Database IDs:

Citations:

PubMed ID: 2279700

Title: Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

PubMed ID: 2279700

DOI: 10.1101/gad.4.12b.2319

PubMed ID: 7990960

Title: Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

PubMed ID: 7990960

DOI: 10.1038/372679a0

PubMed ID: 9989404

Title: Female development in mammals is regulated by Wnt-4 signalling.

PubMed ID: 9989404

DOI: 10.1038/17068

PubMed ID: 10866835

Title: The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PubMed ID: 10866835

DOI: 10.1046/j.1432-1033.2000.01478.x

PubMed ID: 16054034

Title: Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.

PubMed ID: 16054034

DOI: 10.1016/j.devcel.2005.05.016

PubMed ID: 17537789

Title: Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.

PubMed ID: 17537789

DOI: 10.1242/dev.006155

PubMed ID: 19830824

Title: Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse.

PubMed ID: 19830824

DOI: 10.1002/dvg.20566

PubMed ID: 26321050

Title: Wnt4 is essential to normal mammalian lung development.

PubMed ID: 26321050

DOI: 10.1016/j.ydbio.2015.08.017

Sequence Information:

Length: 351
Mass: 39050
Checksum: 7E1C5C739BE939D9
Sequence:

MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI QRQVQMCKRN 
LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK VVTQGTREAA FVYAISSAGV 
AFAVTRACSS GELEKCGCDR TVHGVSPQGF QWSGCSDNIA YGVAFSQSFV DVRERSKGAS 
SSRALMNLHN NEAGRKAILT HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG 
ATEVEPRRVG SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDIRSGVLG TRGRTCNKTS 
KAIDGCELLC CGRGFHTAQV ELAERCGCRF HWCCFVKCRQ CQRLVEMHTC R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wnt4

Associated with

Other Information

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. PubMed ID: 2279700

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. PubMed ID: 7990960

Female development in mammals is regulated by Wnt-4 signalling. PubMed ID: 9989404

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. PubMed ID: 10866835

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. PubMed ID: 16054034

Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. PubMed ID: 17537789

Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. PubMed ID: 19830824

Wnt4 is essential to normal mammalian lung development. PubMed ID: 26321050