Genular: Defining Cellular Identity and Function

Details for: Wnt5a

Gene ID: 22418

Symbol: Wnt5a

Ensembl ID: ENSMUSG00000021994

Description: wingless-type MMTV integration site family, member 5A

Associated with

Asymmetric localization of pcp proteins
(R-MMU-4608870)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Ca2+ pathway
(R-MMU-4086398)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Membrane trafficking
(R-MMU-199991)
Pcp/ce pathway
(R-MMU-4086400)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Vesicle-mediated transport
(R-MMU-5653656)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-MMU-5140745)
Wnt5a-dependent internalization of fzd4
(R-MMU-5099900)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Activation of protein kinase b activity
(GO:0032148)
Animal organ morphogenesis
(GO:0009887)
Anterior/posterior axis specification, embryo
(GO:0008595)
Anterior/posterior pattern specification
(GO:0009952)
Atrial septum development
(GO:0003283)
Axis elongation
(GO:0003401)
Axonal fasciculation
(GO:0007413)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Bmp signaling pathway
(GO:0030509)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Chemoattractant activity involved in axon guidance
(GO:1902379)
Cytokine activity
(GO:0005125)
Cytokine production
(GO:0001816)
Determination of left/right symmetry
(GO:0007368)
Embryo development
(GO:0009790)
Embryonic limb morphogenesis
(GO:0030326)
Epithelial cell migration
(GO:0010631)
Establishment of planar polarity
(GO:0001736)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Frizzled binding
(GO:0005109)
Heart looping
(GO:0001947)
Hindgut morphogenesis
(GO:0007442)
Inflammatory response
(GO:0006954)
Jnk cascade
(GO:0007254)
Kidney development
(GO:0001822)
Lung development
(GO:0030324)
Macrophage derived foam cell differentiation
(GO:0010742)
Male gonad development
(GO:0008584)
Mesenchymal cell proliferation
(GO:0010463)
Midbrain development
(GO:0030901)
Midgut development
(GO:0007494)
Morphogenesis of an epithelium
(GO:0002009)
Multicellular organism development
(GO:0007275)
Negative regulation of bmp signaling pathway
(GO:0030514)
Neural tube closure
(GO:0001843)
Neural tube development
(GO:0021915)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Olfactory bulb interneuron development
(GO:0021891)
Pericardium morphogenesis
(GO:0003344)
Planar cell polarity pathway involved in axis elongation
(GO:0003402)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of cytokine production involved in immune response
(GO:0002720)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of type ii interferon production
(GO:0032729)
Primary heart field specification
(GO:0003138)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Receptor tyrosine kinase-like orphan receptor binding
(GO:0005115)
Secondary heart field specification
(GO:0003139)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Somitogenesis
(GO:0001756)
Type b pancreatic cell development
(GO:0003323)
Ventricular septum development
(GO:0003281)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, calcium modulating pathway
(GO:0007223)

Other Information

Proteins

Protein Wnt-5a

Genular Protein ID: 1259068191

Symbol: WNT5A_MOUSE

Name: Protein Wnt-5a

UniProtKB Accession Codes:

P22725 Q8BM17 Q8BMF9 Q8VCV6

Database IDs:

Citations:

PubMed ID: 2279700

Title: Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

PubMed ID: 2279700

DOI: 10.1101/gad.4.12b.2319

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16602827

Title: Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.

PubMed ID: 16602827

DOI: 10.1371/journal.pbio.0040115

PubMed ID: 10021340

Title: A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.

PubMed ID: 10021340

DOI: 10.1242/dev.126.6.1211

PubMed ID: 10866835

Title: The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PubMed ID: 10866835

DOI: 10.1046/j.1432-1033.2000.01478.x

PubMed ID: 12952940

Title: Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.

PubMed ID: 12952940

DOI: 10.1083/jcb.200303158

PubMed ID: 17117926

Title: Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.

PubMed ID: 17117926

DOI: 10.1042/bj20061476

PubMed ID: 19841259

Title: Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.

PubMed ID: 19841259

DOI: 10.1073/pnas.0904894106

PubMed ID: 22726442

Title: Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

PubMed ID: 22726442

DOI: 10.1016/j.cell.2012.04.039

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

Sequence Information:

Length: 380
Mass: 42309
Checksum: 64CA36C516D22D8A
Sequence:

MKKPIGILSP GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG MNNPVQMSEV 
YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN 
TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG 
GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC 
HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH 
WCCYVKCKKC TEIVDQFVCK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wnt5a

Associated with

Other Information

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. PubMed ID: 2279700

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PubMed ID: 16602827

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. PubMed ID: 10021340

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. PubMed ID: 10866835

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. PubMed ID: 12952940

Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. PubMed ID: 17117926

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. PubMed ID: 19841259

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. PubMed ID: 22726442

The polycystin complex mediates Wnt/Ca(2+) signalling. PubMed ID: 27214281