Genular: Defining Cellular Identity and Function

Details for: Wnt7a

Gene ID: 22421

Symbol: Wnt7a

Ensembl ID: ENSMUSG00000030093

Description: wingless-type MMTV integration site family, member 7A

Associated with

Signaling by wnt
(R-MMU-195721)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process
(GO:0006915)
Asymmetric protein localization involved in cell fate determination
(GO:0045167)
Canonical wnt signaling pathway
(GO:0060070)
Cartilage condensation
(GO:0001502)
Cartilage development
(GO:0051216)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Cell proliferation in forebrain
(GO:0021846)
Cell surface
(GO:0009986)
Central nervous system vasculogenesis
(GO:0022009)
Cerebellar granule cell differentiation
(GO:0021707)
Chondrocyte differentiation
(GO:0002062)
Cytokine activity
(GO:0005125)
Dendritic spine morphogenesis
(GO:0060997)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic axis specification
(GO:0000578)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic forelimb morphogenesis
(GO:0035115)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic limb morphogenesis
(GO:0030326)
Endoplasmic reticulum lumen
(GO:0005788)
Establishment of blood-brain barrier
(GO:0060856)
Establishment of cell polarity
(GO:0030010)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Forelimb morphogenesis
(GO:0035136)
Frizzled binding
(GO:0005109)
Glutamatergic synapse
(GO:0098978)
Hindlimb morphogenesis
(GO:0035137)
Limb development
(GO:0060173)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of neurogenesis
(GO:0050768)
Neuron differentiation
(GO:0030182)
Neurotransmitter secretion
(GO:0007269)
Non-canonical wnt signaling pathway
(GO:0035567)
Oviduct development
(GO:0060066)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of epithelial cell proliferation involved in wound healing
(GO:0060054)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of excitatory synapse assembly
(GO:1904891)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of axon diameter
(GO:0031133)
Regulation of axonogenesis
(GO:0050770)
Regulation of cell population proliferation
(GO:0042127)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of postsynapse organization
(GO:0099175)
Regulation of presynapse assembly
(GO:1905606)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Reproductive structure development
(GO:0048608)
Response to estrogen
(GO:0043627)
Schaffer collateral - ca1 synapse
(GO:0098685)
Secondary palate development
(GO:0062009)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal muscle satellite cell activation
(GO:0014719)
Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
(GO:0014834)
Skeletal system morphogenesis
(GO:0048705)
Skin morphogenesis
(GO:0043589)
Somatic stem cell division
(GO:0048103)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell development
(GO:0048864)
Synapse assembly
(GO:0007416)
Synapse organization
(GO:0050808)
Uterus development
(GO:0060065)
Uterus morphogenesis
(GO:0061038)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Protein Wnt-7a

Genular Protein ID: 1087034647

Symbol: WNT7A_MOUSE

Name: Protein Wnt-7a

UniProtKB Accession Codes:

P24383 Q80VH3 Q9DBY3

Database IDs:

Citations:

PubMed ID: 2279700

Title: Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

PubMed ID: 2279700

DOI: 10.1101/gad.4.12b.2319

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7885472

Title: Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb.

PubMed ID: 7885472

DOI: 10.1038/374350a0

PubMed ID: 9769174

Title: The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.

PubMed ID: 9769174

DOI: 10.1006/dbio.1998.9007

PubMed ID: 9790192

Title: Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a.

PubMed ID: 9790192

DOI: 10.1038/27221

PubMed ID: 10866835

Title: The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PubMed ID: 10866835

DOI: 10.1046/j.1432-1033.2000.01478.x

PubMed ID: 18230341

Title: Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP.

PubMed ID: 18230341

DOI: 10.1016/j.bbrc.2008.01.088

PubMed ID: 20530549

Title: Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis.

PubMed ID: 20530549

DOI: 10.1242/dev.046722

PubMed ID: 23629626

Title: Wnt7a regulates multiple steps of neurogenesis.

PubMed ID: 23629626

DOI: 10.1128/mcb.00325-13

PubMed ID: 28803732

Title: Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation.

PubMed ID: 28803732

DOI: 10.1016/j.neuron.2017.07.031

Sequence Information:

Length: 349
Mass: 38974
Checksum: C36ACDF7930790A1
Sequence:

MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA ICQSRPDAII 
VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG SREAAFTYAI IAAGVAHAIT 
AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG GCSADIRYGI GFAKVFVDAR EIKQNARTLM 
NLHNNEAGRK ILEENMKLEC KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP 
VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wnt7a

Associated with

Other Information

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. PubMed ID: 2279700

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. PubMed ID: 7885472

The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene. PubMed ID: 9769174

Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. PubMed ID: 9790192

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. PubMed ID: 10866835

Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. PubMed ID: 18230341

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. PubMed ID: 20530549

Wnt7a regulates multiple steps of neurogenesis. PubMed ID: 23629626

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation. PubMed ID: 28803732