Details for: Xbp1

Gene ID: 22433

Symbol: Xbp1

Ensembl ID: ENSMUSG00000020484

Description: X-box binding protein 1

Associated with

  • Adipose tissue development
    (GO:0060612)
  • Angiogenesis
    (GO:0001525)
  • Apoptotic process
    (GO:0006915)
  • Autophagy
    (GO:0006914)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to amino acid stimulus
    (GO:0071230)
  • Cellular response to fructose stimulus
    (GO:0071332)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to interleukin-4
    (GO:0071353)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to nutrient
    (GO:0031670)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Cholesterol homeostasis
    (GO:0042632)
  • Chromatin dna binding
    (GO:0031490)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Endothelial cell proliferation
    (GO:0001935)
  • Epithelial cell maturation involved in salivary gland development
    (GO:0060691)
  • Exocrine pancreas development
    (GO:0031017)
  • Fatty acid homeostasis
    (GO:0055089)
  • Glandular epithelial cell maturation
    (GO:0002071)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • Intracellular triglyceride homeostasis
    (GO:0035356)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Lipid metabolic process
    (GO:0006629)
  • Liver development
    (GO:0001889)
  • Multicellular organism development
    (GO:0007275)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of myotube differentiation
    (GO:0010832)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Neuron development
    (GO:0048666)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Phosphatidylinositol 3-kinase regulatory subunit binding
    (GO:0036312)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of tor signaling
    (GO:0032008)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular wound healing
    (GO:0035470)
  • Protease binding
    (GO:0002020)
  • Protein destabilization
    (GO:0031648)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Protein transport
    (GO:0015031)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of protein stability
    (GO:0031647)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to electrical stimulus
    (GO:0051602)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to unfolded protein
    (GO:0006986)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Serotonin secretion, neurotransmission
    (GO:0060096)
  • Sterol homeostasis
    (GO:0055092)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ubiquitin-dependent protein catabolic process
    (GO:0006511)
  • Ubiquitin-like protein ligase binding
    (GO:0044389)
  • Ubiquitin protein ligase binding
    (GO:0031625)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)

Other Information

Genular Protein ID: 3495226975

Symbol: XBP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

O35426 Q8VHM0 Q922G5 Q9ESS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 99 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10907849

Title: Isolation and characterization of the gene encoding mouse tax-responsive element-binding protein (TREB) 5.

PubMed ID: 10907849

DOI: 10.1093/dnares/7.3.187

PubMed ID: 11780124

Title: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

PubMed ID: 11780124

DOI: 10.1038/415092a

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7693055

Title: In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis.

PubMed ID: 7693055

DOI: 10.1002/aja.1001970207

PubMed ID: 10425189

Title: Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage.

PubMed ID: 10425189

DOI: 10.1006/bbrc.1999.0972

PubMed ID: 10652269

Title: An essential role in liver development for transcription factor XBP-1.

PubMed ID: 10652269

PubMed ID: 11850408

Title: IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

PubMed ID: 11850408

DOI: 10.1101/gad.964702

PubMed ID: 14559994

Title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.

PubMed ID: 14559994

DOI: 10.1128/mcb.23.21.7448-7459.2003

PubMed ID: 12612580

Title: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

PubMed ID: 12612580

DOI: 10.1038/ni907

PubMed ID: 12902539

Title: Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.

PubMed ID: 12902539

DOI: 10.1073/pnas.1334037100

PubMed ID: 15486293

Title: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

PubMed ID: 15486293

DOI: 10.1126/science.1103160

PubMed ID: 16362047

Title: XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.

PubMed ID: 16362047

DOI: 10.1038/sj.emboj.7600903

PubMed ID: 16332684

Title: Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response.

PubMed ID: 16332684

DOI: 10.1074/jbc.m509061200

PubMed ID: 17213183

Title: Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.

PubMed ID: 17213183

DOI: 10.1074/jbc.m609490200

PubMed ID: 17612490

Title: XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.

PubMed ID: 17612490

DOI: 10.1016/j.molcel.2007.06.011

PubMed ID: 18775308

Title: XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

PubMed ID: 18775308

DOI: 10.1016/j.cell.2008.07.021

PubMed ID: 18556558

Title: Regulation of hepatic lipogenesis by the transcription factor XBP1.

PubMed ID: 18556558

DOI: 10.1126/science.1158042

PubMed ID: 19416856

Title: Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.

PubMed ID: 19416856

DOI: 10.1073/pnas.0903197106

PubMed ID: 20348926

Title: The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

PubMed ID: 20348926

DOI: 10.1038/nm.2099

PubMed ID: 20955178

Title: Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.

PubMed ID: 20955178

DOI: 10.1042/bj20101293

PubMed ID: 21317886

Title: Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.

PubMed ID: 21317886

DOI: 10.1038/nm.2293

PubMed ID: 23623498

Title: The role of adipocyte XBP1 in metabolic regulation during lactation.

PubMed ID: 23623498

DOI: 10.1016/j.celrep.2013.03.042

PubMed ID: 23529610

Title: Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

PubMed ID: 23529610

DOI: 10.1161/circulationaha.112.001337

PubMed ID: 23184933

Title: XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.

PubMed ID: 23184933

DOI: 10.1074/jbc.m112.412783

PubMed ID: 25223794

Title: X-box binding protein 1 is a novel key regulator of peroxisome proliferator-activated receptor gamma2.

PubMed ID: 25223794

DOI: 10.1111/febs.13052

PubMed ID: 24753614

Title: Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1.

PubMed ID: 24753614

DOI: 10.1073/pnas.1321845111

Sequence Information:

  • Length: 267
  • Mass: 29619
  • Checksum: 15009E684F6D426F
  • Sequence:
    • MVVVAAAPSA ATAAPKVLLL SGQPASGGRA LPLMVPGPRA AGSEASGTPQ ARKRQRLTHL 
SPEEKALRRK LKNRVAAQTA RDRKKARMSE LEQQVVDLEE ENHKLQLENQ LLREKTHGLV 
VENQELRTRL GMDTLDPDEV PEVEAKGSGV RLVAGSAESA ALRLCAPLQQ VQAQLSPPQN 
IFPWTLTLLP LQILSLISFW AFWTSWTLSC FSNVLPQSLL VWRNSQRSTQ KDLVPYQPPF 
LCQWGPHQPS WKPLMNSFVL TMYTPSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.