ABCD2 | ENSG00000173208 | NCBI 225

Details for: ABCD2

Gene ID: 225

Symbol: ABCD2

Ensembl ID: ENSG00000173208

Description: ATP binding cassette subfamily D member 2

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporters in lipid homeostasis
(R-HSA-1369062)
Class i peroxisomal membrane protein import
(R-HSA-9603798)
Protein localization
(R-HSA-9609507)
Transport of small molecules
(R-HSA-382551)
Abc-type transporter activity
(GO:0140359)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytosol
(GO:0005829)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acyl-coa hydrolase activity
(GO:0047617)
Long-chain fatty acid import into peroxisome
(GO:0015910)
Long-chain fatty acid transporter activity
(GO:0005324)
Myelin maintenance
(GO:0043217)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Neuron projection maintenance
(GO:1990535)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Peroxisome organization
(GO:0007031)
Positive regulation of fatty acid beta-oxidation
(GO:0032000)
Positive regulation of unsaturated fatty acid biosynthetic process
(GO:2001280)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Response to bacterium
(GO:0009617)
Very long-chain fatty acid catabolic process
(GO:0042760)
Very long-chain fatty acid metabolic process
(GO:0000038)

Other Information

Proteins

ATP-binding cassette sub-family D member 2

Genular Protein ID: 1162570089

Symbol: ABCD2_HUMAN

Name: ATP-binding cassette sub-family D member 2

UniProtKB Accession Codes:

Q9UBJ2 B2RAM3 Q13210 Q2M3H9

Database IDs:

Citations:

PubMed ID: 8577752

Title: A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.

PubMed ID: 8577752

DOI: 10.1073/pnas.93.3.1265

PubMed ID: 9345306

Title: cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter.

PubMed ID: 9345306

DOI: 10.1006/bbrc.1997.7391

PubMed ID: 10329405

Title: Full length cDNA cloning, promoter sequence, and genomic organization of the human adrenoleukodystrophy related (ALDR) gene functionally redundant to the gene responsible for X-linked adrenoleukodystrophy.

PubMed ID: 10329405

DOI: 10.1006/bbrc.1999.0535

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10551832

Title: Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.

PubMed ID: 10551832

DOI: 10.1074/jbc.274.46.32738

PubMed ID: 10777694

Title: Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.

PubMed ID: 10777694

DOI: 10.1006/bbrc.2000.2572

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 16946495

Title: ATP-binding and -hydrolysis activities of ALDP (ABCD1) and ALDRP (ABCD2), human peroxisomal ABC proteins, overexpressed in Sf21 cells.

PubMed ID: 16946495

DOI: 10.1248/bpb.29.1836

PubMed ID: 17609205

Title: Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3).

PubMed ID: 17609205

DOI: 10.1074/jbc.m702122200

PubMed ID: 21145416

Title: Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid beta-oxidation.

PubMed ID: 21145416

DOI: 10.1016/j.bbalip.2010.11.010

PubMed ID: 29397936

Title: Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes.

PubMed ID: 29397936

DOI: 10.1016/j.bbrc.2018.01.153

PubMed ID: 18772397

Title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

PubMed ID: 18772397

DOI: 10.1126/science.1164368

Sequence Information:

Length: 740
Mass: 83233
Checksum: 9F3C8DBB8AB156E3
Sequence:

MTHMLNAAAD RVKWTRSSAA KRAACLVAAA YALKTLYPII GKRLKQSGHG KKKAAAYPAA 
ENTEILHCTE TICEKPSPGV NADFFKQLLE LRKILFPKLV TTETGWLCLH SVALISRTFL 
SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW LMIAIPATFV NSAIRYLECK LALAFRTRLV 
DHAYETYFTN QTYYKVINMD GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVMLTSY 
TLIQTATSRG ASPIGPTLLA GLVVYATAKV LKACSPKFGK LVAEEAHRKG YLRYVHSRII 
ANVEEIAFYR GHKVEMKQLQ KSYKALADQM NLILSKRLWY IMIEQFLMKY VWSSSGLIMV 
AIPIITATGF ADGEDGQKQV MVSERTEAFT TARNLLASGA DAIERIMSSY KEVTELAGYT 
ARVYNMFWVF DEVKRGIYKR TAVIQESESH SKNGAKVELP LSDTLAIKGK VIDVDHGIIC 
ENVPIITPAG EVVASRLNFK VEEGMHLLIT GPNGCGKSSL FRILSGLWPV YEGVLYKPPP 
QHMFYIPQRP YMSLGSLRDQ VIYPDSVDDM HDKGYTDQDL ERILHNVHLY HIVQREGGWD 
AVMDWKDVLS GGEKQRMGMA RMFYHKPKYA LLDECTSAVS IDVEGKIFQA AKGAGISLLS 
ITHRPSLWKY HTHLLQFDGE GGWRFEQLDT AIRLTLSEEK QKLESQLAGI PKMQQRLNEL 
CKILGEDSVL KTIKNEDETS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ABCD2

Associated with

Other Information

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. PubMed ID: 8577752

cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter. PubMed ID: 9345306

Full length cDNA cloning, promoter sequence, and genomic organization of the human adrenoleukodystrophy related (ALDR) gene functionally redundant to the gene responsible for X-linked adrenoleukodystrophy. PubMed ID: 10329405

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters. PubMed ID: 10551832

Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. PubMed ID: 10777694

PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. PubMed ID: 10704444

ATP-binding and -hydrolysis activities of ALDP (ABCD1) and ALDRP (ABCD2), human peroxisomal ABC proteins, overexpressed in Sf21 cells. PubMed ID: 16946495

Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3). PubMed ID: 17609205

Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid beta-oxidation. PubMed ID: 21145416

Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes. PubMed ID: 29397936

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. PubMed ID: 18772397