Genular: Defining Cellular Identity and Function

Details for: Xrcc1

Gene ID: 22594

Symbol: Xrcc1

Ensembl ID: ENSMUSG00000051768

Description: X-ray repair complementing defective repair in Chinese hamster cells 1

Associated with

Apex1-independent resolution of ap sites via the single nucleotide replacement pathway
(R-MMU-5649702)
Base excision repair
(R-MMU-73884)
Dna double-strand break repair
(R-MMU-5693532)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Homology directed repair
(R-MMU-5693538)
Nucleotide excision repair
(R-MMU-5696398)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Resolution of ap sites via the single-nucleotide replacement pathway
(R-MMU-110381)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
3' overhang single-stranded dna endodeoxyribonuclease activity
(GO:1990599)
Adp-d-ribose modification-dependent protein binding
(GO:0160002)
Base-excision repair
(GO:0006284)
Cerebellum morphogenesis
(GO:0021587)
Chromatin
(GO:0000785)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Damaged dna binding
(GO:0003684)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Enzyme binding
(GO:0019899)
Ercc4-ercc1 complex
(GO:0070522)
Hippocampus development
(GO:0021766)
Negative regulation of protection from non-homologous end joining at telomere
(GO:1905765)
Negative regulation of protein adp-ribosylation
(GO:0010836)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidized dna binding
(GO:0032356)
Poly-adp-d-ribose binding
(GO:0072572)
Positive regulation of dna ligase activity
(GO:1904877)
Positive regulation of single strand break repair
(GO:1903518)
Replication-born double-strand break repair via sister chromatid exchange
(GO:1990414)
Response to hydroperoxide
(GO:0033194)
Single strand break repair
(GO:0000012)
Site of dna damage
(GO:0090734)
Telomeric dna-containing double minutes formation
(GO:0061819)
Voluntary musculoskeletal movement
(GO:0050882)

Other Information

Proteins

DNA repair protein XRCC1
Q3TGI0_MOUSE

Genular Protein ID: 2971383301

Symbol: XRCC1_MOUSE

Name: DNA repair protein XRCC1

UniProtKB Accession Codes:

Q60596 Q3THC5 Q5U435 Q7TNQ5

Database IDs:

Citations:

PubMed ID: 7959765

Title: Isolation and characterization of mouse Xrcc-1, a DNA repair gene affecting ligation.

PubMed ID: 7959765

DOI: 10.1006/geno.1994.1359

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28002403

Title: XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.

PubMed ID: 28002403

DOI: 10.1038/nature20790

Sequence Information:

Length: 631
Mass: 68971
Checksum: 1A730F206E5B8879
Sequence:

MPEISLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI 
GNDGSAFVEV LVGSSAGGAT AGEQDYEVLL VTSSFMSPSE SRSGSNPNRV RIFGPDKLVR 
AAAEKRWDRV KIVCSQPYSK DSPYGLSFVK FHSPPDKDEA EATSQKVTVT KLGQFRVKEE 
DDSANSLKPG ALFFSRINKT SSASTSDPAG PSYAAATLQA SSAASSASPV PKVVGSSSKP 
QEPPKGKRKL DLSLEDRKPP SKPSAGPSTL KRPKLSVPSR TPAAAPASTP AQRAVPGKPR 
GEGTEPRGAR TGPQELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTPDSTHL 
ICAFANTPKY SQVLGLGGRI VRKEWVLDCH HMRRRLPSRR YLMAGLGSSS EDEGDSHSES 
GEDEAPKLPQ KRPQPKAKTQ AAGPSSPPRP PTPKETKAPS PGPQDNSDTE GEESEGRDNG 
AEDSGDTEDE LRRVAKQREQ RQPPAPEENG EDPYAGSTDE NTDSETPSEA DLPIPELPDF 
FEGKHFFLYG EFPGDERRRL IRYVTAFNGE LEDYMNERVQ FVITAQEWDP NFEEALMENP 
SLAFVRPRWI YSCNEKQKLL PHQLYGVVPQ A

Genular Protein ID: 2711751373

Symbol: Q3TGI0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TGI0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 630
Mass: 68811
Checksum: BAF902C23F8A62CA
Sequence:

MPEISLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI 
GNDGSAFVEV LVGSSAGGAT AGEQDYEVLL VTSSFMSPSE SRSGSNPNRV RIFGPDKLVR 
AAAEKRWDRV KIVCSQPYSK DSPYGLSFVK FHSPPDKDEA EATSQVTVTK LGQFRVKEED 
DSANSLKPGA LFFSRINKTS SASTSDPAGP SYAAATLQAS SAASSASPVP KVVGSSSKPQ 
EPPKGKRKLD LSLEDRKPPS KPSAGPSTLK RPKLSVPSRT PAAAPASTPA QRAVPGKPRG 
EGTEPRGART GPQELGKILQ GVVVVLSGFQ NPFRSELRDK ALELGAKYRP DWTPDSTHLI 
CAFANTPKYS QVLGLGGRIV RKEWVLDCHH MRRRLPSRRY LVAGLGSSSE DEGDSHSESG 
EDEAPKLPQK RPQPKAKTQA AGPSSPPRPP TPKETKAPSP GPQDNSDTEG EESEGRDNGA 
EDSGDTEDEL RRVAKQREQR QPPAPEENGE DPYAGSTDEN TDSETPSEAD LPIPELPDFF 
EGKHFFLYGE FPGDERRRLI RYVTAFNGEL EDYMNERVQF VITAQEWDPN FEEALMENPS 
LAFVRPRWIY SCNEKQKLLP HQLYGVVPQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Xrcc1

Associated with

Other Information

Isolation and characterization of mouse Xrcc-1, a DNA repair gene affecting ligation. PubMed ID: 7959765

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. PubMed ID: 28002403

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073