Genular: Defining Cellular Identity and Function

Details for: Xrcc5

Gene ID: 22596

Symbol: Xrcc5

Ensembl ID: ENSMUSG00000026187

Description: X-ray repair complementing defective repair in Chinese hamster cells 5

Associated with

Dna double-strand break repair
(R-MMU-5693532)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
5'-deoxyribose-5-phosphate lyase activity
(GO:0051575)
Activation of innate immune response
(GO:0002218)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular hyperosmotic salinity response
(GO:0071475)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to x-ray
(GO:0071481)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Damaged dna binding
(GO:0003684)
Dna-dependent protein kinase-dna ligase 4 complex
(GO:0005958)
Dna-dependent protein kinase complex
(GO:0070418)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna end binding
(GO:0045027)
Dna helicase activity
(GO:0003678)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Double-stranded dna binding
(GO:0003690)
Double-stranded telomeric dna binding
(GO:0003691)
Helicase activity
(GO:0004386)
Hematopoietic stem cell differentiation
(GO:0060218)
Hematopoietic stem cell proliferation
(GO:0071425)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Ku70:ku80 complex
(GO:0043564)
Leptotene
(GO:0000237)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of t-circle formation
(GO:1904430)
Neurogenesis
(GO:0022008)
Nonhomologous end joining complex
(GO:0070419)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Recombinational repair
(GO:0000725)
Regulation of smooth muscle cell proliferation
(GO:0048660)
Ribonucleoprotein complex
(GO:1990904)
Ribosome biogenesis
(GO:0042254)
Rna binding
(GO:0003723)
Site of dna damage
(GO:0090734)
Small-subunit processome
(GO:0032040)
Small-subunit processome assembly
(GO:0034462)
Telomere maintenance
(GO:0000723)
Telomeric dna binding
(GO:0042162)
Transcription cis-regulatory region binding
(GO:0000976)
U3 snorna binding
(GO:0034511)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

X-ray repair cross-complementing protein 5

Genular Protein ID: 819176810

Symbol: XRCC5_MOUSE

Name: X-ray repair cross-complementing protein 5

UniProtKB Accession Codes:

P27641 Q3TE46 Q3TJT0 Q3TN82 Q80UT1 Q8C4N6 Q8K1K7 Q9R169

Database IDs:

Citations:

PubMed ID: 1641347

Title: The nucleotide sequence of a mouse cDNA encoding the 80 kDa subunit of the Ku (p70/p80) autoantigen.

PubMed ID: 1641347

DOI: 10.1093/nar/20.14.3784

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8605992

Title: Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes.

PubMed ID: 8605992

DOI: 10.1016/0014-5793(96)00189-5

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30017584

Title: MRI is a DNA damage response adaptor during classical non-homologous end joining.

PubMed ID: 30017584

DOI: 10.1016/j.molcel.2018.06.018

Sequence Information:

Length: 732
Mass: 83057
Checksum: 391F0FAF7EB04288
Sequence:

MAWSGNKAAV VLCVDVGVAM GNSFPGEESP IEQAKKVMTM FVQRQVFSES KDEIALVLYG 
TDGTDNALAG KDQYQNITVC RHLMLPDFDL LEDIGNKIQP SSQQADFLDA LIVCMDLIQR 
ETIGKKFGKK HIEVFTDLSS PFSQDQLDVI ICNLKKSGIS LQFFLPFPID KNGEPGERGD 
LDSGLDHLKP SFPQKGLTEQ QKEGIRMVTR VMLSLEGEDG LDEIYSFSES LRQLCVFKKI 
ERRSMPWPCQ LTIGPNLSIK IVAYKSIVQE KFKKSWVVVD ARTLKKEDIQ KETVYCLNDD 
DETEVSKEDT IQGYRYGSDI IPFSKVDEEQ MKYKSEGKCF SVLGFCKSSQ VHRRFFMGHQ 
VLKVFAAKDD EAAAVALSSL VHALDELNMV AIVRYAYDKR SNPQVGVAFP YIKDAYECLV 
YVQLPFMEDL RQYMFSSLKN NKKCTPTEAQ LSAIDDLIDS MSLVKKNEEE DIVEDLFPTS 
KIPNPEFQRL YQCLLHRALH LQERLPPIQQ HILNMLDPPT EMKAKCESPL SKVKTLFPLT 
EVIKKKNQVT AQDVFQDNHE EGPAAKKYKT EKEEDHISIS SLAEGNITKV GSVNPVENFR 
FLVRQKIASF EEASLQLISH IEQFLDTNET LYFMKSMDCI KAFREEAIQF SEEQRFNSFL 
EALREKVEIK QLNHFWEIVV QDGVTLITKD EGPGSSITAE EATKFLAPKD KAKEDTTGPE 
EAGDVDDLLD MI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Xrcc5

Associated with

Other Information

The nucleotide sequence of a mouse cDNA encoding the 80 kDa subunit of the Ku (p70/p80) autoantigen. PubMed ID: 1641347

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes. PubMed ID: 8605992

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079