Gene ALDOA - ENSG00000149925 | NCBI Gene ID: 226

Details for: ALDOA

Gene ID: 226

Symbol: ALDOA

Ensembl ID: ENSG00000149925

Description: aldolase, fructose-bisphosphate A

Associated with

Gluconeogenesis
(R-HSA-70263)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Neutrophil degranulation
(R-HSA-6798695)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament organization
(GO:0007015)
Atp biosynthetic process
(GO:0006754)
Binding of sperm to zona pellucida
(GO:0007339)
Cadherin binding
(GO:0045296)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Fructose-bisphosphate aldolase activity
(GO:0004332)
Fructose 1,6-bisphosphate metabolic process
(GO:0030388)
Fructose binding
(GO:0070061)
Fructose metabolic process
(GO:0006000)
Glycolytic process
(GO:0006096)
I band
(GO:0031674)
Identical protein binding
(GO:0042802)
M band
(GO:0031430)
Membrane
(GO:0016020)
Muscle cell cellular homeostasis
(GO:0046716)
Nucleus
(GO:0005634)
Platelet alpha granule lumen
(GO:0031093)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of cell shape
(GO:0008360)
Rna binding
(GO:0003723)
Secretory granule lumen
(GO:0034774)
Sperm head
(GO:0061827)
Striated muscle contraction
(GO:0006941)
Tertiary granule lumen
(GO:1904724)
Tubulin binding
(GO:0015631)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.12
Marker Score: 3610
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.69
Marker Score: 5658
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.23
Marker Score: 3995
Cell Name: germ cell (CL0000586)
Fold Change: 4.18
Marker Score: 7303
Cell Name: mature T cell (CL0002419)
Fold Change: 4.08
Marker Score: 40358
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.89
Marker Score: 4702
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.67
Marker Score: 10138
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.48
Marker Score: 2626
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.48
Marker Score: 7068.5
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.47
Marker Score: 2637
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.38
Marker Score: 188804
Cell Name: supporting cell (CL0000630)
Fold Change: 3.34
Marker Score: 6284
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.33
Marker Score: 3334
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.31
Marker Score: 24662
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.3
Marker Score: 114306
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.29
Marker Score: 25714
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.28
Marker Score: 5384.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.27
Marker Score: 9539
Cell Name: blood cell (CL0000081)
Fold Change: 3.27
Marker Score: 37955
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.19
Marker Score: 3645.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.15
Marker Score: 4099
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.14
Marker Score: 7814
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.12
Marker Score: 2781
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.12
Marker Score: 1827
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.12
Marker Score: 6069
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.05
Marker Score: 5228
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.93
Marker Score: 4667
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.92
Marker Score: 3246
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.9
Marker Score: 18569
Cell Name: myelocyte (CL0002193)
Fold Change: 2.89
Marker Score: 1247
Cell Name: basophil (CL0000767)
Fold Change: 2.87
Marker Score: 1363
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.87
Marker Score: 17005
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.86
Marker Score: 969
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.85
Marker Score: 6960
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.85
Marker Score: 7253
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.8
Marker Score: 1612
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.79
Marker Score: 6728.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.79
Marker Score: 2182
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.78
Marker Score: 11390
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.78
Marker Score: 71231
Cell Name: decidual cell (CL2000002)
Fold Change: 2.78
Marker Score: 11976
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.77
Marker Score: 18005
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.77
Marker Score: 1104
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.72
Marker Score: 23657.5
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.72
Marker Score: 4375
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.72
Marker Score: 11658
Cell Name: club cell (CL0000158)
Fold Change: 2.71
Marker Score: 3169
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.71
Marker Score: 1497
Cell Name: acinar cell (CL0000622)
Fold Change: 2.69
Marker Score: 1901
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.69
Marker Score: 3717
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.69
Marker Score: 3891
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.68
Marker Score: 8468
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.68
Marker Score: 1205
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.66
Marker Score: 23381
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.66
Marker Score: 47265
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.66
Marker Score: 1368
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.65
Marker Score: 7224
Cell Name: theca cell (CL0000503)
Fold Change: 2.64
Marker Score: 1889
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.63
Marker Score: 635
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.63
Marker Score: 8252
Cell Name: naive T cell (CL0000898)
Fold Change: 2.63
Marker Score: 1692
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.62
Marker Score: 4039
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.61
Marker Score: 2294
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 2.6
Marker Score: 833
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.59
Marker Score: 16892
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.58
Marker Score: 4391
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.56
Marker Score: 1855
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.56
Marker Score: 652
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.56
Marker Score: 6626
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.56
Marker Score: 5106
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.55
Marker Score: 2119
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.53
Marker Score: 2704
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.53
Marker Score: 1555
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.53
Marker Score: 28469
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.52
Marker Score: 3572.5
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.52
Marker Score: 2370
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.52
Marker Score: 2785
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.51
Marker Score: 25279
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.51
Marker Score: 2818
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.5
Marker Score: 15210
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.49
Marker Score: 3454
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.47
Marker Score: 1759
Cell Name: kidney cell (CL1000497)
Fold Change: 2.47
Marker Score: 1650
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.45
Marker Score: 6408
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.41
Marker Score: 8927
Cell Name: muscle cell (CL0000187)
Fold Change: 2.41
Marker Score: 682
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.39
Marker Score: 1402
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.39
Marker Score: 1609
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.39
Marker Score: 3518
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 2.38
Marker Score: 989
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.38
Marker Score: 2303
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.38
Marker Score: 6780
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.38
Marker Score: 993
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.37
Marker Score: 125332
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.37
Marker Score: 891
Cell Name: reticular cell (CL0000432)
Fold Change: 2.36
Marker Score: 861
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.35
Marker Score: 4194.5
Cell Name: Unknown (CL0002371)
Fold Change: 2.34
Marker Score: 2481
Cell Name: Unknown (CL0000548)
Fold Change: 2.33
Marker Score: 1697
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.31
Marker Score: 1094

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**Key characteristics** * The ALDOA gene is located on chromosome 15q21.1. * It is a single-exon gene encoding a protein of 123 amino acids. * The protein is expressed in high levels in cells of the immune system, particularly in monocytes and macrophages. **Pathways and functions** * ALDOA enzymes are involved in the metabolism of fructose-bisphosphate, a product of glycolysis. * They catalyze the transfer of a phosphate group from fructose-bisphosphate to other molecules, such as glyceraldehyde-3-phosphate and phosphoglycerate. * This process is essential for the regulation of blood glucose metabolism and for the synthesis of lipids and proteins. **Clinical significance** * Mutations in the ALDOA gene have been linked to several human diseases, including cancer and inflammation. * In cancer, ALDOA mutations can lead to the activation of oncogenes and the development of tumors. * The ALDOA gene has also been implicated in inflammation and autoimmune disorders. **Additional information** * The ALDOA gene is also known as CD147. * It is a highly conserved enzyme that is found in organisms from yeast to humans. * ALDOA is a substrate for the protein kinase C kinase (PKC).

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lung cancer antigen NY-LU-1

Genular Protein ID: 556857321

Symbol: ALDOA_HUMAN

Name: Lung cancer antigen NY-LU-1

UniProtKB Accession Codes:

P04075 B4DXI7 Q6FH76 Q6FI10 Q96B15 Q9BWD9 Q9UCN2

Database IDs:

Citations:

PubMed ID: 3840020

Title: Nucleotide sequence of a cDNA clone for human aldolase: a messenger RNA in the liver.

PubMed ID: 3840020

DOI: 10.1016/0006-291x(85)91818-2

PubMed ID: 3030757

Title: A new human species of aldolase A mRNA from fibroblasts.

PubMed ID: 3030757

DOI: 10.1111/j.1432-1033.1987.tb10984.x

PubMed ID: 3391172

Title: Human aldolase A gene. Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing.

PubMed ID: 3391172

DOI: 10.1111/j.1432-1033.1988.tb14136.x

PubMed ID: 1999195

Title: An additional promoter functions in the human aldolase A gene, but not in rat.

PubMed ID: 1999195

DOI: 10.1111/j.1432-1033.1991.tb15766.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3441006

Title: Characterization of three optional promoters in the 5' region of the human aldolase A gene.

PubMed ID: 3441006

DOI: 10.1016/0022-2836(87)90556-0

PubMed ID: 3355497

Title: The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.

PubMed ID: 3355497

DOI: 10.1042/bj2490779

PubMed ID: 6696436

Title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.

PubMed ID: 6696436

DOI: 10.1016/0003-9861(84)90075-4

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1353685

Title: Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase-specific probe.

PubMed ID: 1353685

DOI: 10.1016/0167-4889(92)90078-p

PubMed ID: 3674018

Title: Evolutionary implications of the human aldolase-A, -B, -C, and - pseudogene chromosome locations.

PubMed ID: 3674018

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18214967

Title: Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.

PubMed ID: 18214967

DOI: 10.1002/prot.21909

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 2335208

Title: The crystal structure of human muscle aldolase at 3.0-A resolution.

PubMed ID: 2335208

DOI: 10.1016/0014-5793(90)80211-z

PubMed ID: 2056525

Title: Activity and specificity of human aldolases.

PubMed ID: 2056525

DOI: 10.1016/0022-2836(91)90650-u

PubMed ID: 10048322

Title: Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications.

PubMed ID: 10048322

DOI: 10.1110/ps.8.2.291

PubMed ID: 2825199

Title: Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation.

PubMed ID: 2825199

DOI: 10.1073/pnas.84.23.8623

PubMed ID: 2229018

Title: Human aldolase A of a hemolytic anemia patient with Asp-128-->Gly substitution: characteristics of an enzyme generated in E. coli transfected with the expression plasmid pHAAD128G.

PubMed ID: 2229018

DOI: 10.1093/oxfordjournals.jbchem.a123174

PubMed ID: 8598869

Title: Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A.

PubMed ID: 8598869

DOI: 10.1056/nejm199604253341705

PubMed ID: 14615364

Title: Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr).

PubMed ID: 14615364

DOI: 10.1182/blood-2003-09-3160

PubMed ID: 14766013

Title: Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function.

PubMed ID: 14766013

DOI: 10.1042/bj20031941

Sequence Information:

Length: 364
Mass: 39420
Checksum: 0AAED80F755A7BE8
Sequence:

MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR 
QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN 
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ 
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC 
TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF 
SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS 
NHAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ALDOA

Associated with

Cells (max top 100)

Other Information

Nucleotide sequence of a cDNA clone for human aldolase: a messenger RNA in the liver. PubMed ID: 3840020

A new human species of aldolase A mRNA from fibroblasts. PubMed ID: 3030757

Human aldolase A gene. Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing. PubMed ID: 3391172

An additional promoter functions in the human aldolase A gene, but not in rat. PubMed ID: 1999195

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of three optional promoters in the 5' region of the human aldolase A gene. PubMed ID: 3441006

The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase. PubMed ID: 3355497

Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments. PubMed ID: 6696436

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase-specific probe. PubMed ID: 1353685

Evolutionary implications of the human aldolase-A, -B, -C, and - pseudogene chromosome locations. PubMed ID: 3674018

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. PubMed ID: 18214967

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The first identification of lysine malonylation substrates and its regulatory enzyme. PubMed ID: 21908771

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. PubMed ID: 29192674

p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. PubMed ID: 29775581

The crystal structure of human muscle aldolase at 3.0-A resolution. PubMed ID: 2335208

Activity and specificity of human aldolases. PubMed ID: 2056525

Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications. PubMed ID: 10048322

Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation. PubMed ID: 2825199

Human aldolase A of a hemolytic anemia patient with Asp-128--&gt;Gly substitution: characteristics of an enzyme generated in E. coli transfected with the expression plasmid pHAAD128G. PubMed ID: 2229018

Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A. PubMed ID: 8598869

Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). PubMed ID: 14615364

Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function. PubMed ID: 14766013