Details for: ALDOA

Gene ID: 226

Symbol: ALDOA

Ensembl ID: ENSG00000149925

Description: aldolase, fructose-bisphosphate A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 433.0252
    Cell Significance Index: -67.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 254.0575
    Cell Significance Index: -64.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 210.7185
    Cell Significance Index: -86.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 210.5440
    Cell Significance Index: -85.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 182.0037
    Cell Significance Index: -93.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 127.4325
    Cell Significance Index: -85.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 92.3338
    Cell Significance Index: -88.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.9244
    Cell Significance Index: -76.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.2719
    Cell Significance Index: -83.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.1547
    Cell Significance Index: -52.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.6533
    Cell Significance Index: -32.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.4905
    Cell Significance Index: 655.8000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 10.6691
    Cell Significance Index: 31.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.6470
    Cell Significance Index: 224.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.5035
    Cell Significance Index: 59.9100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.7472
    Cell Significance Index: 39.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.1210
    Cell Significance Index: 160.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.9193
    Cell Significance Index: 2686.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.9628
    Cell Significance Index: 1140.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7161
    Cell Significance Index: -9.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2690
    Cell Significance Index: 41.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.2342
    Cell Significance Index: 168.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.8723
    Cell Significance Index: 284.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3776
    Cell Significance Index: 82.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5893
    Cell Significance Index: 42.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8464
    Cell Significance Index: 116.2300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7681
    Cell Significance Index: 13.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7232
    Cell Significance Index: 78.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5706
    Cell Significance Index: 92.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5244
    Cell Significance Index: 99.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5184
    Cell Significance Index: 6.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5021
    Cell Significance Index: 380.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4352
    Cell Significance Index: 26.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3726
    Cell Significance Index: 10.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3348
    Cell Significance Index: 15.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3045
    Cell Significance Index: 134.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2878
    Cell Significance Index: 21.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2250
    Cell Significance Index: 40.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2220
    Cell Significance Index: 28.4600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.2041
    Cell Significance Index: 0.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1007
    Cell Significance Index: 1.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0922
    Cell Significance Index: 1.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0751
    Cell Significance Index: 3.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0633
    Cell Significance Index: 1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0547
    Cell Significance Index: 5.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0501
    Cell Significance Index: 45.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0206
    Cell Significance Index: 0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0119
    Cell Significance Index: 2.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0398
    Cell Significance Index: -29.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0411
    Cell Significance Index: -77.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0428
    Cell Significance Index: -78.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0457
    Cell Significance Index: -5.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0511
    Cell Significance Index: -78.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0561
    Cell Significance Index: -9.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0580
    Cell Significance Index: -78.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0934
    Cell Significance Index: -52.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1029
    Cell Significance Index: -75.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1084
    Cell Significance Index: -14.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1425
    Cell Significance Index: -8.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1426
    Cell Significance Index: -90.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1867
    Cell Significance Index: -84.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1904
    Cell Significance Index: -68.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2012
    Cell Significance Index: -42.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2223
    Cell Significance Index: -15.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2460
    Cell Significance Index: -5.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3077
    Cell Significance Index: -6.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3115
    Cell Significance Index: -35.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3156
    Cell Significance Index: -14.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3355
    Cell Significance Index: -39.1000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.3854
    Cell Significance Index: -1.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4171
    Cell Significance Index: -6.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4253
    Cell Significance Index: -29.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4435
    Cell Significance Index: -88.0200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4798
    Cell Significance Index: -3.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4904
    Cell Significance Index: -30.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5877
    Cell Significance Index: -14.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6130
    Cell Significance Index: -89.1000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6414
    Cell Significance Index: -5.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6868
    Cell Significance Index: -78.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7172
    Cell Significance Index: -84.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7718
    Cell Significance Index: -8.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7790
    Cell Significance Index: -24.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8081
    Cell Significance Index: -84.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8149
    Cell Significance Index: -38.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8487
    Cell Significance Index: -11.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8730
    Cell Significance Index: -15.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9038
    Cell Significance Index: -69.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0509
    Cell Significance Index: -67.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0953
    Cell Significance Index: -86.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.3288
    Cell Significance Index: -36.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4159
    Cell Significance Index: -86.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.4676
    Cell Significance Index: -16.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5139
    Cell Significance Index: -44.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5408
    Cell Significance Index: -15.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5664
    Cell Significance Index: -87.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.5707
    Cell Significance Index: -37.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5769
    Cell Significance Index: -42.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ALDOA is a fructose-bisphosphate aldolase, which means it catalyzes the conversion of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is a crucial step in glycolysis, the primary metabolic pathway for energy production in cells. The enzyme exhibits a high degree of specificity for fructose-1,6-bisphosphate, with a Km value of approximately 1.5 mM. ALDOA is also sensitive to inhibition by fructose-2,6-bisphosphate, a potent allosteric inhibitor of glycolysis. **Pathways and Functions** ALDOA is involved in several cellular pathways, including: 1. **Glycolysis**: ALDOA plays a critical role in the breakdown of glucose into energy for the cell through glycolysis. 2. **Gluconeogenesis**: ALDOA is also involved in the regulation of gluconeogenesis, the metabolic pathway that generates glucose from non-carbohydrate sources. 3. **Immune response**: ALDOA is highly expressed in immune cells, such as monocytes and natural killer cells, where it is involved in the regulation of immune responses. 4. **Neurotransmission**: ALDOA is expressed in neurons, where it is involved in the regulation of neurotransmitter release and synaptic plasticity. 5. **Muscle contraction**: ALDOA is also expressed in skeletal muscle cells, where it is involved in the regulation of muscle contraction and relaxation. **Clinical Significance** ALDOA has been implicated in various diseases and disorders, including: 1. **Lung cancer**: ALDOA has been identified as a tumor antigen in lung cancer, with high expression levels in lung cancer cells. 2. **Neurodegenerative diseases**: ALDOA has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of glucose metabolism and neurotransmitter release. 3. **Immune system disorders**: ALDOA has been implicated in immune system disorders, such as rheumatoid arthritis and multiple sclerosis, where it is involved in the regulation of immune responses. 4. **Metabolic disorders**: ALDOA has been implicated in metabolic disorders, such as diabetes and metabolic syndrome, where it is involved in the regulation of glucose metabolism. In conclusion, ALDOA is a crucial enzyme involved in glycolysis, gluconeogenesis, and immune response. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of ALDOA in human health and disease.

Genular Protein ID: 556857321

Symbol: ALDOA_HUMAN

Name: Lung cancer antigen NY-LU-1

UniProtKB Accession Codes:

P04075 B4DXI7 Q6FH76 Q6FI10 Q96B15 Q9BWD9 Q9UCN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 3 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EC 1 EMBL 17 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 6 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3840020

Title: Nucleotide sequence of a cDNA clone for human aldolase: a messenger RNA in the liver.

PubMed ID: 3840020

DOI: 10.1016/0006-291x(85)91818-2

PubMed ID: 3030757

Title: A new human species of aldolase A mRNA from fibroblasts.

PubMed ID: 3030757

DOI: 10.1111/j.1432-1033.1987.tb10984.x

PubMed ID: 3391172

Title: Human aldolase A gene. Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing.

PubMed ID: 3391172

DOI: 10.1111/j.1432-1033.1988.tb14136.x

PubMed ID: 1999195

Title: An additional promoter functions in the human aldolase A gene, but not in rat.

PubMed ID: 1999195

DOI: 10.1111/j.1432-1033.1991.tb15766.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3441006

Title: Characterization of three optional promoters in the 5' region of the human aldolase A gene.

PubMed ID: 3441006

DOI: 10.1016/0022-2836(87)90556-0

PubMed ID: 3355497

Title: The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.

PubMed ID: 3355497

DOI: 10.1042/bj2490779

PubMed ID: 6696436

Title: Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.

PubMed ID: 6696436

DOI: 10.1016/0003-9861(84)90075-4

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1353685

Title: Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase-specific probe.

PubMed ID: 1353685

DOI: 10.1016/0167-4889(92)90078-p

PubMed ID: 3674018

Title: Evolutionary implications of the human aldolase-A, -B, -C, and - pseudogene chromosome locations.

PubMed ID: 3674018

PubMed ID: 2204832

Title: Expression, purification, biochemical characterization and inhibition of recombinant Plasmodium falciparum aldolase.

PubMed ID: 2204832

DOI: 10.1016/0166-6851(90)90189-s

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18214967

Title: Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.

PubMed ID: 18214967

DOI: 10.1002/prot.21909

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 2335208

Title: The crystal structure of human muscle aldolase at 3.0-A resolution.

PubMed ID: 2335208

DOI: 10.1016/0014-5793(90)80211-z

PubMed ID: 2056525

Title: Activity and specificity of human aldolases.

PubMed ID: 2056525

DOI: 10.1016/0022-2836(91)90650-u

PubMed ID: 10048322

Title: Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications.

PubMed ID: 10048322

DOI: 10.1110/ps.8.2.291

PubMed ID: 2825199

Title: Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation.

PubMed ID: 2825199

DOI: 10.1073/pnas.84.23.8623

PubMed ID: 2229018

Title: Human aldolase A of a hemolytic anemia patient with Asp-128-->Gly substitution: characteristics of an enzyme generated in E. coli transfected with the expression plasmid pHAAD128G.

PubMed ID: 2229018

DOI: 10.1093/oxfordjournals.jbchem.a123174

PubMed ID: 8598869

Title: Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A.

PubMed ID: 8598869

DOI: 10.1056/nejm199604253341705

PubMed ID: 14615364

Title: Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr).

PubMed ID: 14615364

DOI: 10.1182/blood-2003-09-3160

PubMed ID: 14766013

Title: Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function.

PubMed ID: 14766013

DOI: 10.1042/bj20031941

Sequence Information:

  • Length: 364
  • Mass: 39420
  • Checksum: 0AAED80F755A7BE8
  • Sequence:
    • MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR 
QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN 
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ 
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC 
TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF 
SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS 
NHAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.