Genular: Defining Cellular Identity and Function

Details for: Yap1

Gene ID: 22601

Symbol: Yap1

Ensembl ID: ENSMUSG00000053110

Description: yes-associated protein 1

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Nuclear signaling by erbb4
(R-MMU-1251985)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Runx3 regulates yap1-mediated transcription
(R-MMU-8951671)
Signaling by erbb4
(R-MMU-1236394)
Signaling by hippo
(R-MMU-2028269)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx3
(R-MMU-8878159)
Yap1- and wwtr1 (taz)-stimulated gene expression
(R-MMU-2032785)
Blastocyst development
(GO:0001824)
Bud elongation involved in lung branching
(GO:0060449)
Canonical wnt signaling pathway
(GO:0060070)
Cardiac muscle tissue regeneration
(GO:0061026)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to retinoic acid
(GO:0071300)
Chromatin binding
(GO:0003682)
Contact inhibition
(GO:0060242)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Embryonic heart tube morphogenesis
(GO:0003143)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Glandular epithelial cell differentiation
(GO:0002067)
Heart process
(GO:0003015)
Hippo signaling
(GO:0035329)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Intestinal epithelial cell development
(GO:0060576)
Intestinal epithelial cell differentiation
(GO:0060575)
Keratinocyte differentiation
(GO:0030216)
Lateral mesoderm development
(GO:0048368)
Lung epithelial cell differentiation
(GO:0060487)
Negative regulation of cilium assembly
(GO:1902018)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notochord development
(GO:0030903)
Organ growth
(GO:0035265)
Paraxial mesoderm development
(GO:0048339)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of organ growth
(GO:0046622)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of stem cell population maintenance
(GO:1902459)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Progesterone receptor signaling pathway
(GO:0050847)
Proline-rich region binding
(GO:0070064)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of cell population proliferation
(GO:0042127)
Regulation of gene expression
(GO:0010468)
Regulation of keratinocyte proliferation
(GO:0010837)
Regulation of metanephric nephron tubule epithelial cell differentiation
(GO:0072307)
Regulation of neurogenesis
(GO:0050767)
Regulation of stem cell proliferation
(GO:0072091)
Response to progesterone
(GO:0032570)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Somatic stem cell population maintenance
(GO:0035019)
Tissue homeostasis
(GO:0001894)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)
Trophectodermal cell differentiation
(GO:0001829)
Vasculogenesis
(GO:0001570)
Wound healing
(GO:0042060)

Other Information

Proteins

Transcriptional coactivator YAP1

Genular Protein ID: 2420794175

Symbol: YAP1_MOUSE

Name: Transcriptional coactivator YAP1

UniProtKB Accession Codes:

P46938 Q52KJ5 Q91WL1

Database IDs:

Citations:

PubMed ID: 7782338

Title: Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain.

PubMed ID: 7782338

DOI: 10.1074/jbc.270.24.14733

PubMed ID: 12807903

Title: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

PubMed ID: 12807903

DOI: 10.1074/jbc.m305597200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7644498

Title: The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

PubMed ID: 7644498

DOI: 10.1073/pnas.92.17.7819

PubMed ID: 9407065

Title: The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.

PubMed ID: 9407065

DOI: 10.1074/jbc.272.52.32869

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16461361

Title: Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.

PubMed ID: 16461361

DOI: 10.1083/jcb.200509132

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20123908

Title: Structural basis of YAP recognition by TEAD4 in the hippo pathway.

PubMed ID: 20123908

DOI: 10.1101/gad.1865310

PubMed ID: 24462371

Title: Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

PubMed ID: 24462371

DOI: 10.1016/j.ajhg.2014.01.001

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 29400695

Title: Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

PubMed ID: 29400695

DOI: 10.1172/jci90429

Sequence Information:

Length: 488
Mass: 52383
Checksum: 5A2221B74B1400F9
Sequence:

MEPAQQPPPQ PAPQGPAPPS VSPAGTPAAP PAPPAGHQVV HVRGDSETDL EALFNAVMNP 
KTANVPQTVP MRLRKLPDSF FKPPEPKSHS RQASTDAGTA GALTPQHVRA HSSPASLQLG 
AVSPGTLTAS GVVSGPAAAP AAQHLRQSSF EIPDDVPLPA GWEMAKTSSG QRYFLNHNDQ 
TTTWQDPRKA MLSQLNVPAP ASPAVPQTLM NSASGPLPDG WEQAMTQDGE VYYINHKNKT 
TSWLDPRLDP RFAMNQRITQ SAPVKQPPPL APQSPQGGVL GGGSSNQQQQ IQLQQLQMEK 
ERLRLKQQEL FRQAIRNINP STANAPKCQE LALRSQLPTL EQDGGTPNAV SSPGMSQELR 
TMTTNSSDPF LNSGTYHSRD ESTDSGLSMS SYSIPRTPDD FLNSVDEMDT GDTISQSTLP 
SQQSRFPDYL EALPGTNVDL GTLEGDAMNI EGEELMPSLQ EALSSEILDV ESVLAATKLD 
KESFLTWL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Yap1

Associated with

Other Information

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. PubMed ID: 7782338

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. PubMed ID: 12807903

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. PubMed ID: 7644498

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. PubMed ID: 9407065

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. PubMed ID: 16461361

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

Structural basis of YAP recognition by TEAD4 in the hippo pathway. PubMed ID: 20123908

Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects. PubMed ID: 24462371

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. PubMed ID: 28087714

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. PubMed ID: 29400695