Genular: Defining Cellular Identity and Function

Details for: Yes1

Gene ID: 22612

Symbol: Yes1

Ensembl ID: ENSMUSG00000014932

Description: YES proto-oncogene 1, Src family tyrosine kinase

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
Cd28 co-stimulation
(R-MMU-389356)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Epha-mediated growth cone collapse
(R-MMU-3928663)
Ephb-mediated forward signaling
(R-MMU-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Fcgr activation
(R-MMU-2029481)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Nervous system development
(R-MMU-9675108)
Pecam1 interactions
(R-MMU-210990)
Regulation of kit signaling
(R-MMU-1433559)
Regulation of signaling by cbl
(R-MMU-912631)
Signaling by erbb2
(R-MMU-1227986)
Signaling by interleukins
(R-MMU-449147)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Signal transduction
(R-MMU-162582)
Actin filament
(GO:0005884)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cellular response to retinoic acid
(GO:0071300)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Epidermal growth factor receptor binding
(GO:0005154)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Innate immune response
(GO:0045087)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynaptic specialization, intracellular component
(GO:0099091)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of glucose transmembrane transport
(GO:0010827)
Signaling receptor binding
(GO:0005102)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Tyrosine-protein kinase Yes

Genular Protein ID: 1047715309

Symbol: YES_MOUSE

Name: Tyrosine-protein kinase Yes

UniProtKB Accession Codes:

Q04736

Database IDs:

Citations:

PubMed ID: 8437854

Title: Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase.

PubMed ID: 8437854

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8206383

Title: Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line.

PubMed ID: 8206383

DOI: 10.1016/0378-1119(94)90106-6

PubMed ID: 7681396

Title: Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

PubMed ID: 7681396

DOI: 10.1002/j.1460-2075.1993.tb05735.x

PubMed ID: 7958873

Title: Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

PubMed ID: 7958873

DOI: 10.1101/gad.8.17.1999

PubMed ID: 9058199

Title: Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes.

PubMed ID: 9058199

DOI: 10.1093/oxfordjournals.jbchem.a021551

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

Sequence Information:

Length: 541
Mass: 60630
Checksum: 9A773C39D2119EA6
Sequence:

MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV NFNSLSMTPF 
GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 
NTEGDWWEAR SIATGKSGYI PSNYVVPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 
LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 
HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 
GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLICKI ADFGLARLIE 
DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 
EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 
L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Yes1

Associated with

Other Information

Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase. PubMed ID: 8437854

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line. PubMed ID: 8206383

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. PubMed ID: 7681396

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. PubMed ID: 7958873

Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. PubMed ID: 9058199

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A phosphotyrosine switch regulates organic cation transporters. PubMed ID: 26979622