Genular: Defining Cellular Identity and Function

Details for: Ywhae

Gene ID: 22627

Symbol: Ywhae

Ensembl ID: ENSMUSG00000020849

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Associated with

Activation of bad and translocation to mitochondria
(R-MMU-111447)
Activation of bh3-only proteins
(R-MMU-114452)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Apoptosis
(R-MMU-109581)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Centrosome maturation
(R-MMU-380287)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-MMU-75035)
Cilium assembly
(R-MMU-5617833)
Death receptor signaling
(R-MMU-73887)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hsf1 activation
(R-MMU-3371511)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Membrane trafficking
(R-MMU-199991)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Nade modulates death signalling
(R-MMU-205025)
Organelle biogenesis and maintenance
(R-MMU-1852241)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Programmed cell death
(R-MMU-5357801)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab regulation of trafficking
(R-MMU-9007101)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate pkns
(R-MMU-5625740)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hippo
(R-MMU-2028269)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Vesicle-mediated transport
(R-MMU-5653656)
Axon
(GO:0030424)
Calcium channel regulator activity
(GO:0005246)
Cellular response to heat
(GO:0034605)
Central region of growth cone
(GO:0090724)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Glutamatergic synapse
(GO:0098978)
Hippocampus development
(GO:0021766)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Kinesin complex
(GO:0005871)
Mapk cascade
(GO:0000165)
Mitochondrion
(GO:0005739)
Negative regulation of calcium ion export across plasma membrane
(GO:1905913)
Negative regulation of calcium ion transmembrane transporter activity
(GO:1901020)
Negative regulation of peptidyl-serine dephosphorylation
(GO:1902309)
Negative regulation of protein dephosphorylation
(GO:0035308)
Neuron migration
(GO:0001764)
Nucleus
(GO:0005634)
Phosphoprotein binding
(GO:0051219)
Phosphoserine residue binding
(GO:0050815)
Plasma membrane
(GO:0005886)
Positive regulation of protein export from nucleus
(GO:0046827)
Potassium channel regulator activity
(GO:0015459)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein localization to nucleus
(GO:0034504)
Protein phosphatase binding
(GO:0019903)
Protein sequestering activity
(GO:0140311)
Protein targeting
(GO:0006605)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of membrane repolarization
(GO:0060306)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of postsynaptic membrane neurotransmitter receptor levels
(GO:0099072)
Regulation of potassium ion transmembrane transporter activity
(GO:1901016)
Scaffold protein binding
(GO:0097110)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

14-3-3 protein epsilon

Genular Protein ID: 3210513653

Symbol: 1433E_MOUSE

Name: 14-3-3 protein epsilon

UniProtKB Accession Codes:

P62259 P29360 P42655 Q63631

Database IDs:

Citations:

PubMed ID: 7750640

Title: The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation.

PubMed ID: 7750640

DOI: 10.1006/dbio.1995.1139

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 11278287

Title: 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction.

PubMed ID: 11278287

DOI: 10.1074/jbc.m005453200

PubMed ID: 11533041

Title: Identification of a novel interaction of 14-3-3 with p190RhoGEF.

PubMed ID: 11533041

DOI: 10.1074/jbc.m107709200

PubMed ID: 12796778

Title: 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.

PubMed ID: 12796778

DOI: 10.1038/ng1169

PubMed ID: 15722337

Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.

PubMed ID: 15722337

DOI: 10.1074/jbc.m501477200

PubMed ID: 17320046

Title: Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.

PubMed ID: 17320046

DOI: 10.1016/j.bbrc.2007.02.028

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21078877

Title: Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.

PubMed ID: 21078877

DOI: 10.1128/mcb.00717-10

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 30973865

Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

PubMed ID: 30973865

DOI: 10.1371/journal.pbio.3000194

Sequence Information:

Length: 255
Mass: 29174
Checksum: 07817CCBD1F75B26
Sequence:

MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW 
RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF 
YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF 
YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE 
EQNKEALQDV EDENQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ywhae

Associated with

Other Information

The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. PubMed ID: 7750640

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. PubMed ID: 10409742

14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. PubMed ID: 11278287

Identification of a novel interaction of 14-3-3 with p190RhoGEF. PubMed ID: 11533041

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. PubMed ID: 12796778

Phosphorylation of grb10 regulates its interaction with 14-3-3. PubMed ID: 15722337

Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. PubMed ID: 17320046

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. PubMed ID: 21078877

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PubMed ID: 30973865