Genular: Defining Cellular Identity and Function

Details for: Ywhaz

Gene ID: 22631

Symbol: Ywhaz

Ensembl ID: ENSMUSG00000022285

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Associated with

Activation of bad and translocation to mitochondria
(R-MMU-111447)
Activation of bh3-only proteins
(R-MMU-114452)
Adaptive immune system
(R-MMU-1280218)
Apoptosis
(R-MMU-109581)
Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-MMU-75035)
Cytokine signaling in immune system
(R-MMU-1280215)
Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Foxo-mediated transcription
(R-MMU-9614085)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gp1b-ix-v activation signalling
(R-MMU-430116)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Ksrp (khsrp) binds and destabilizes mrna
(R-MMU-450604)
Metabolism of rna
(R-MMU-8953854)
Notch4 activation and transmission of signal to the nucleus
(R-MMU-9013700)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Programmed cell death
(R-MMU-5357801)
Rap1 signalling
(R-MMU-392517)
Regulation of localization of foxo transcription factors
(R-MMU-9614399)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate pkns
(R-MMU-5625740)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by interleukins
(R-MMU-449147)
Signaling by notch
(R-MMU-157118)
Signaling by notch4
(R-MMU-9013694)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Angiogenesis
(GO:0001525)
Cell leading edge
(GO:0031252)
Cellular response to glucose starvation
(GO:0042149)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of golgi localization
(GO:0051683)
Glutamatergic synapse
(GO:0098978)
Golgi reassembly
(GO:0090168)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Histamine secretion by mast cell
(GO:0002553)
Identical protein binding
(GO:0042802)
Lung development
(GO:0030324)
Mitochondrion
(GO:0005739)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of protein localization to nucleus
(GO:1900181)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphoserine residue binding
(GO:0050815)
Postsynaptic specialization
(GO:0099572)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein sequestering activity
(GO:0140311)
Protein targeting
(GO:0006605)
Protein targeting to mitochondrion
(GO:0006626)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of programmed cell death
(GO:0043067)
Regulation of synapse maturation
(GO:0090128)
Respiratory system process
(GO:0003016)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Synaptic target recognition
(GO:0008039)
Transmembrane transporter binding
(GO:0044325)
Tube formation
(GO:0035148)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

14-3-3 protein zeta/delta

Genular Protein ID: 2501936125

Symbol: 1433Z_MOUSE

Name: 14-3-3 protein zeta/delta

UniProtKB Accession Codes:

P63101 P35215 P70197 P97286 Q3TSF1 Q5EBQ1

Database IDs:

Citations:

PubMed ID: 8645260

Title: Molecular characterization of seizure-related genes isolated by differential screening.

PubMed ID: 8645260

DOI: 10.1006/bbrc.1996.0313

PubMed ID: 9197417

Title: The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins.

PubMed ID: 9197417

DOI: 10.1007/s004380050453

PubMed ID: 9016762

Title: 14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase.

PubMed ID: 9016762

DOI: 10.1006/bbrc.1996.5933

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9705322

Title: A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.

PubMed ID: 9705322

DOI: 10.1074/jbc.273.34.21834

PubMed ID: 10455159

Title: Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.

PubMed ID: 10455159

DOI: 10.1074/jbc.274.35.24865

PubMed ID: 12176995

Title: MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.

PubMed ID: 12176995

DOI: 10.1074/jbc.m206041200

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20478393

Title: SLy2 targets the nuclear SAP30/HDAC1 complex.

PubMed ID: 20478393

DOI: 10.1016/j.biocel.2010.05.004

PubMed ID: 21478148

Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

PubMed ID: 21478148

DOI: 10.1074/jbc.m110.197707

PubMed ID: 22701344

Title: Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.

PubMed ID: 22701344

DOI: 10.7150/ijbs.4036

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

Sequence Information:

Length: 245
Mass: 27771
Checksum: 2164DF3793B45B7A
Sequence:

MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR 
VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QPESKVFYLK 
MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE 
ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG 
EGGEN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ywhaz

Associated with

Other Information

Molecular characterization of seizure-related genes isolated by differential screening. PubMed ID: 8645260

The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. PubMed ID: 9197417

14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase. PubMed ID: 9016762

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. PubMed ID: 9705322

Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. PubMed ID: 10455159

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. PubMed ID: 12176995

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. PubMed ID: 16959763

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SLy2 targets the nuclear SAP30/HDAC1 complex. PubMed ID: 20478393

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. PubMed ID: 21478148

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. PubMed ID: 22701344

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703