Genular: Defining Cellular Identity and Function

Details for: Yy1

Gene ID: 22632

Symbol: Yy1

Ensembl ID: ENSMUSG00000021264

Description: YY1 transcription factor

Associated with

Deubiquitination
(R-MMU-5688426)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Metabolism of proteins
(R-MMU-392499)
Nucleotide excision repair
(R-MMU-5696398)
Post-translational protein modification
(R-MMU-597592)
Uch proteinases
(R-MMU-5689603)
Anterior/posterior pattern specification
(GO:0009952)
B cell differentiation
(GO:0030183)
Camera-type eye morphogenesis
(GO:0048593)
Cell differentiation
(GO:0030154)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to uv
(GO:0034644)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Chromatin silencing complex
(GO:0005677)
Chromosome organization
(GO:0051276)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-strand break repair via homologous recombination
(GO:0000724)
Four-way junction dna binding
(GO:0000400)
Gene expression
(GO:0010467)
Hemopoiesis
(GO:0030097)
Immunoglobulin heavy chain v-d-j recombination
(GO:0071707)
Ino80 complex
(GO:0031011)
Metal ion binding
(GO:0046872)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of interferon-beta production
(GO:0032688)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of telomere maintenance in response to dna damage
(GO:1904507)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of chromosome organization
(GO:0033044)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna repair
(GO:0006282)
Regulation of dna replication
(GO:0006275)
Regulation of dna strand elongation
(GO:0060382)
Regulation of embryonic development
(GO:0045995)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to uv-c
(GO:0010225)
Rna binding
(GO:0003723)
Rna localization
(GO:0006403)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smad binding
(GO:0046332)
Spermatogenesis
(GO:0007283)
Telomere maintenance
(GO:0000723)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Transcriptional repressor protein YY1

Genular Protein ID: 4250065139

Symbol: TYY1_MOUSE

Name: Transcriptional repressor protein YY1

UniProtKB Accession Codes:

Q00899

Database IDs:

Citations:

PubMed ID: 1309593

Title: Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus.

PubMed ID: 1309593

DOI: 10.1128/mcb.12.1.38-44.1992

PubMed ID: 8516301

Title: Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor.

PubMed ID: 8516301

DOI: 10.1073/pnas.90.12.5559

PubMed ID: 1946404

Title: Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

PubMed ID: 1946404

DOI: 10.1073/pnas.88.21.9799

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15329343

Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.

PubMed ID: 15329343

DOI: 10.1242/dev.01344

PubMed ID: 18026119

Title: A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

PubMed ID: 18026119

DOI: 10.1038/nsmb1332

PubMed ID: 18024232

Title: The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.

PubMed ID: 18024232

DOI: 10.1016/j.modgep.2007.09.005

PubMed ID: 19786570

Title: Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis.

PubMed ID: 19786570

DOI: 10.1128/mcb.00679-09

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21454521

Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.

PubMed ID: 21454521

DOI: 10.1074/jbc.m110.133603

Sequence Information:

Length: 414
Mass: 44717
Checksum: C012378288E984F9
Sequence:

MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD DEDGGGGDHG 
GGGGGHGHAG HHHHHHHHHH HHPPMIALQP LVTDDPTQVH HHQEVILVQT REEVVGGDDS 
DGLRAEDGFE DQILIPVPAP AGGDDDYIEQ TLVTVAAAGK SGGGASSGGG RVKKGGGKKS 
GKKSYLGGGA GAAGGGGADP GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE 
QIIGENSPPD YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH 
KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE KPFQCTFEGC 
GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL KSHILTHAKA KNNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Yy1

Associated with

Other Information

Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. PubMed ID: 1309593

Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. PubMed ID: 8516301

Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. PubMed ID: 1946404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. PubMed ID: 15329343

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. PubMed ID: 18026119

The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues. PubMed ID: 18024232

Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis. PubMed ID: 19786570

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. PubMed ID: 21454521