Genular: Defining Cellular Identity and Function

Details for: Zap70

Gene ID: 22637

Symbol: Zap70

Ensembl ID: ENSMUSG00000026117

Description: zeta-chain (TCR) associated protein kinase

Associated with

Adaptive immune system
(R-MMU-1280218)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Tcr signaling
(R-MMU-202403)
Translocation of zap-70 to immunological synapse
(R-MMU-202430)
Adaptive immune response
(GO:0002250)
Alpha-beta t cell differentiation
(GO:0046632)
Atp binding
(GO:0005524)
Beta selection
(GO:0043366)
Calcium-mediated signaling
(GO:0019722)
Cell-cell junction
(GO:0005911)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Immunological synapse
(GO:0001772)
Innate immune response
(GO:0045087)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Negative thymic t cell selection
(GO:0045060)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphorylation
(GO:0016310)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of alpha-beta t cell differentiation
(GO:0046638)
Positive regulation of alpha-beta t cell proliferation
(GO:0046641)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of t cell differentiation
(GO:0045582)
Positive thymic t cell selection
(GO:0045059)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Signaling receptor binding
(GO:0005102)
T cell differentiation
(GO:0030217)
T cell receptor complex
(GO:0042101)
T cell receptor signaling pathway
(GO:0050852)
Thymic t cell selection
(GO:0045061)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Tyrosine-protein kinase ZAP-70

Genular Protein ID: 3644656842

Symbol: ZAP70_MOUSE

Name: Tyrosine-protein kinase ZAP-70

UniProtKB Accession Codes:

P43404 P97455 Q80VV2 Q8CHJ3

Database IDs:

Citations:

PubMed ID: 8196616

Title: Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.

PubMed ID: 8196616

DOI: 10.1128/mcb.14.6.3729-3741.1994

PubMed ID: 9208839

Title: A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.

PubMed ID: 9208839

DOI: 10.1016/s1074-7613(00)80442-2

PubMed ID: 14985102

Title: Identification of a novel isoform of ZAP-70, truncated ZAP kinase.

PubMed ID: 14985102

DOI: 10.1016/j.bbrc.2004.01.127

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7630421

Title: Essential role for ZAP-70 in both positive and negative selection of thymocytes.

PubMed ID: 7630421

DOI: 10.1038/376435a0

PubMed ID: 10662792

Title: Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling.

PubMed ID: 10662792

DOI: 10.1084/jem.191.3.463

PubMed ID: 10646608

Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

PubMed ID: 10646608

DOI: 10.1038/35003228

PubMed ID: 11891219

Title: A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.

PubMed ID: 11891219

DOI: 10.1074/jbc.m110318200

PubMed ID: 12648457

Title: SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.

PubMed ID: 12648457

DOI: 10.1016/s1074-7613(03)00054-2

PubMed ID: 12705855

Title: Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

PubMed ID: 12705855

DOI: 10.1016/s1074-7613(03)00082-7

PubMed ID: 15143214

Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.

PubMed ID: 15143214

DOI: 10.1073/pnas.0401119101

PubMed ID: 17028588

Title: RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.

PubMed ID: 17028588

DOI: 10.1038/ni1396

PubMed ID: 17606633

Title: Distinct roles for Syk and ZAP-70 during early thymocyte development.

PubMed ID: 17606633

DOI: 10.1084/jem.20070405

PubMed ID: 26903241

Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.

PubMed ID: 26903241

DOI: 10.1084/jem.20151426

Sequence Information:

Length: 618
Mass: 70112
Checksum: 9E0D18B240B28392
Sequence:

MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP 
IERQLNGTYA IAGGKAHCGP AELCQFYSQD PDGLPCNLRK PCNRPPGLEP QPGVFDCLRD 
AMVRDYVRQT WKLEGDALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG 
QQTDGKFLLR PRKEQGTYAL SLVYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK 
LKADGLIYRL KEVCPNSSAS AAVAAPTLPA HPSTFTQPQR RVDTLNSDGY TPEPARLASS 
TDKPRPMPMD TSVYESPYSD PEELKDKKLF LKRENLLVAD IELGCGNFGS VRQGVYRMRK 
KQIDVAIKVL KQGTEKADKD EMMREAQIMH QLDNPYIVRL IGVCQAEALM LVMEMAGGGP 
LHKFLLGKKE EIPVSNVAEL LHQVAMGMKY LEEKNFVHRD LAARNVLLVN RHYAKISDFG 
LSKALGADDS YYTARSAGKW PLKWYAPECI NFRKFSSRSD VWSYGVTMWE AFSYGQKPYK 
KMKGPEVLDF IKQGKRMECP PECPPEMYAL MSDCWIYKWE DRPDFLTVEQ RMRNYYYSLA 
SRAEGPPQCE QVAEAACG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Zap70

Associated with

Other Information

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. PubMed ID: 8196616

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. PubMed ID: 9208839

Identification of a novel isoform of ZAP-70, truncated ZAP kinase. PubMed ID: 14985102

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Essential role for ZAP-70 in both positive and negative selection of thymocytes. PubMed ID: 7630421

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. PubMed ID: 10662792

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. PubMed ID: 10646608

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. PubMed ID: 11891219

SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. PubMed ID: 12648457

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. PubMed ID: 12705855

NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. PubMed ID: 15143214

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. PubMed ID: 17028588

Distinct roles for Syk and ZAP-70 during early thymocyte development. PubMed ID: 17606633

Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. PubMed ID: 26903241