Genular: Defining Cellular Identity and Function

Details for: Pcgf2

Gene ID: 22658

Symbol: Pcgf2

Ensembl ID: ENSMUSG00000018537

Description: polycomb group ring finger 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of chromatin organization proteins
(R-MMU-4551638)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Sumoylation of rna binding proteins
(R-MMU-4570464)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Transcriptional regulation by e2f6
(R-MMU-8953750)
Anterior/posterior pattern specification
(GO:0009952)
Apoptotic signaling pathway
(GO:0097190)
Cellular response to hydrogen peroxide
(GO:0070301)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Dna binding
(GO:0003677)
Embryonic skeletal system development
(GO:0048706)
Embryonic skeletal system morphogenesis
(GO:0048704)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Prc1 complex
(GO:0035102)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Sex chromatin
(GO:0001739)
Ubiquitin-protein transferase activator activity
(GO:0097027)

Other Information

Proteins

Polycomb group RING finger protein 2

Genular Protein ID: 3374506380

Symbol: PCGF2_MOUSE

Name: Polycomb group RING finger protein 2

UniProtKB Accession Codes:

P23798

Database IDs:

Citations:

PubMed ID: 2246278

Title: Expression of novel DNA-binding protein with zinc finger structure in various tumor cells.

PubMed ID: 2246278

DOI: 10.1016/s0021-9258(17)45476-7

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521824

Title: mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.

PubMed ID: 8521824

DOI: 10.1002/j.1460-2075.1995.tb00254.x

PubMed ID: 8625838

Title: A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton.

PubMed ID: 8625838

DOI: 10.1242/dev.122.5.1513

PubMed ID: 11750047

Title: Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18.

PubMed ID: 11750047

DOI: 10.1016/s0165-2478(01)00315-7

PubMed ID: 12480532

Title: Dimerization of the Polycomb-group protein Mel-18 is regulated by PKC phosphorylation.

PubMed ID: 12480532

DOI: 10.1016/s0006-291x(02)02791-2

PubMed ID: 15183898

Title: Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells.

PubMed ID: 15183898

DOI: 10.1016/j.exphem.2004.03.001

PubMed ID: 15728456

Title: Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway.

PubMed ID: 15728456

DOI: 10.4049/jimmunol.174.5.2507

PubMed ID: 16024804

Title: Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.

PubMed ID: 16024804

DOI: 10.1128/mcb.25.15.6694-6706.2005

PubMed ID: 22226355

Title: Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.

PubMed ID: 22226355

DOI: 10.1016/j.stem.2011.12.006

Sequence Information:

Length: 342
Mass: 37723
Checksum: C23031B8B9E30108
Sequence:

MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 
EKGALGDDEI VSLSIEFYEG VRDREEKKNL TENGDGDKEK TGVRFLRCPA AMTVMHLAKF 
LRNKMDVPSK YKVEILYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLPT 
VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP 
TPPSTAAGTT TATNGGTSNC LQTPSSTSRG RKMTVNGAPC PP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pcgf2

Associated with

Other Information

Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. PubMed ID: 2246278

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. PubMed ID: 8521824

A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. PubMed ID: 8625838

Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18. PubMed ID: 11750047

Dimerization of the Polycomb-group protein Mel-18 is regulated by PKC phosphorylation. PubMed ID: 12480532

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. PubMed ID: 15183898

Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. PubMed ID: 15728456

Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. PubMed ID: 16024804

Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. PubMed ID: 22226355