Details for: Zfp36

Gene ID: 22695

Symbol: Zfp36

Ensembl ID: ENSMUSG00000044786

Description: zinc finger protein 36

Associated with

  • Metabolism of rna
    (R-MMU-8953854)
  • Regulation of mrna stability by proteins that bind au-rich elements
    (R-MMU-450531)
  • Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
    (R-MMU-450513)
  • 3'-utr-mediated mrna destabilization
    (GO:0061158)
  • 3'-utr-mediated mrna stabilization
    (GO:0070935)
  • 14-3-3 protein binding
    (GO:0071889)
  • C-c chemokine binding
    (GO:0019957)
  • Ccr4-not complex
    (GO:0030014)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cellular response to granulocyte macrophage colony-stimulating factor stimulus
    (GO:0097011)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cytoplasm
    (GO:0005737)
  • Cytoplasmic stress granule
    (GO:0010494)
  • Cytosol
    (GO:0005829)
  • Dna binding
    (GO:0003677)
  • Enzyme binding
    (GO:0019899)
  • Exosome (rnase complex)
    (GO:0000178)
  • Heat shock protein binding
    (GO:0031072)
  • Hematopoietic stem cell differentiation
    (GO:0060218)
  • Intracellular signal transduction
    (GO:0035556)
  • Mapk cascade
    (GO:0000165)
  • Metal ion binding
    (GO:0046872)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mrna 3'-utr au-rich region binding
    (GO:0035925)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna binding
    (GO:0003729)
  • Mrna catabolic process
    (GO:0006402)
  • Mrna transport
    (GO:0051028)
  • Multicellular organism development
    (GO:0007275)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Negative regulation of hematopoietic stem cell differentiation
    (GO:1902037)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Negative regulation of polynucleotide adenylyltransferase activity
    (GO:1904246)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of viral transcription
    (GO:0032897)
  • Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:0000288)
  • Nuclear-transcribed mrna catabolic process, deadenylation-independent decay
    (GO:0031086)
  • Nuclear-transcribed mrna poly(a) tail shortening
    (GO:0000289)
  • Nucleus
    (GO:0005634)
  • P-body
    (GO:0000932)
  • P38mapk cascade
    (GO:0038066)
  • Positive regulation of deadenylation-independent decapping of nuclear-transcribed mrna
    (GO:1901835)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of intracellular mrna localization
    (GO:1904582)
  • Positive regulation of mirna-mediated gene silencing
    (GO:2000637)
  • Positive regulation of mrna catabolic process
    (GO:0061014)
  • Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:1900153)
  • Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060213)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of keratinocyte apoptotic process
    (GO:1902172)
  • Regulation of keratinocyte differentiation
    (GO:0045616)
  • Regulation of keratinocyte proliferation
    (GO:0010837)
  • Regulation of mrna stability
    (GO:0043488)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of tumor necrosis factor production
    (GO:0032680)
  • Response to starvation
    (GO:0042594)
  • Response to wounding
    (GO:0009611)
  • Ribonucleoprotein complex
    (GO:1990904)
  • Rna destabilization
    (GO:0050779)
  • Rna polymerase binding
    (GO:0070063)

Other Information

Genular Protein ID: 2726420597

Symbol: TTP_MOUSE

Name: N/A

UniProtKB Accession Codes:

P22893 P11520

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 61 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 2 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2204625

Title: Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.

PubMed ID: 2204625

DOI: 10.1016/s0021-9258(17)46259-4

PubMed ID: 1699942

Title: A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.

PubMed ID: 1699942

DOI: 10.1016/s0021-9258(17)30642-7

PubMed ID: 2915901

Title: Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.

PubMed ID: 2915901

PubMed ID: 1861870

Title: A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene.

PubMed ID: 1861870

PubMed ID: 1996120

Title: The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.

PubMed ID: 1996120

DOI: 10.1128/mcb.11.3.1754-1758.1991

PubMed ID: 7559666

Title: Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.

PubMed ID: 7559666

DOI: 10.1074/jbc.270.42.25266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7768935

Title: Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.

PubMed ID: 7768935

DOI: 10.1074/jbc.270.22.13341

PubMed ID: 8630730

Title: A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.

PubMed ID: 8630730

DOI: 10.1016/s1074-7613(00)80411-2

PubMed ID: 9703499

Title: Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.

PubMed ID: 9703499

DOI: 10.1126/science.281.5379.1001

PubMed ID: 10330172

Title: Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

PubMed ID: 10330172

DOI: 10.1128/mcb.19.6.4311

PubMed ID: 10706852

Title: Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.

PubMed ID: 10706852

PubMed ID: 10805719

Title: Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway.

PubMed ID: 10805719

DOI: 10.1128/mcb.20.11.3753-3763.2000

PubMed ID: 11533235

Title: Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.

PubMed ID: 11533235

DOI: 10.1128/mcb.21.9.6461-6469.2001

PubMed ID: 11796723

Title: Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling.

PubMed ID: 11796723

DOI: 10.1074/jbc.m111457200

PubMed ID: 11886850

Title: Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.

PubMed ID: 11886850

DOI: 10.1074/jbc.m110465200

PubMed ID: 15014438

Title: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.

PubMed ID: 15014438

DOI: 10.1038/sj.emboj.7600163

PubMed ID: 14688255

Title: MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.

PubMed ID: 14688255

DOI: 10.1074/jbc.m310486200

PubMed ID: 15187092

Title: The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself.

PubMed ID: 15187092

DOI: 10.1074/jbc.m402059200

PubMed ID: 15967811

Title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

PubMed ID: 15967811

DOI: 10.1083/jcb.200502088

PubMed ID: 15634918

Title: Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay.

PubMed ID: 15634918

DOI: 10.4049/jimmunol.174.2.953

PubMed ID: 16514065

Title: Interferons limit inflammatory responses by induction of tristetraprolin.

PubMed ID: 16514065

DOI: 10.1182/blood-2005-07-3058

PubMed ID: 16508014

Title: Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.

PubMed ID: 16508014

DOI: 10.1128/mcb.26.6.2399-2407.2006

PubMed ID: 16508015

Title: Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

PubMed ID: 16508015

DOI: 10.1128/mcb.26.6.2408-2418.2006

PubMed ID: 17030620

Title: Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts.

PubMed ID: 17030620

DOI: 10.1128/mcb.00945-06

PubMed ID: 17288565

Title: Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes.

PubMed ID: 17288565

DOI: 10.1111/j.1742-4658.2007.05632.x

PubMed ID: 17170118

Title: Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA.

PubMed ID: 17170118

DOI: 10.1074/jbc.m607347200

PubMed ID: 17971298

Title: Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells.

PubMed ID: 17971298

DOI: 10.1016/j.bbrc.2007.10.119

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19188452

Title: Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.

PubMed ID: 19188452

DOI: 10.1128/mcb.00982-08

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20595389

Title: MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.

PubMed ID: 20595389

DOI: 10.1074/jbc.m110.136473

PubMed ID: 20221403

Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed ID: 20221403

DOI: 10.1371/journal.pone.0009588

PubMed ID: 21078877

Title: Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.

PubMed ID: 21078877

DOI: 10.1128/mcb.00717-10

PubMed ID: 21278420

Title: Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.

PubMed ID: 21278420

DOI: 10.1093/nar/gkr011

PubMed ID: 22701344

Title: Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.

PubMed ID: 22701344

DOI: 10.7150/ijbs.4036

PubMed ID: 22844456

Title: Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1.

PubMed ID: 22844456

DOI: 10.1371/journal.pone.0041313

PubMed ID: 23046558

Title: A role for RNA post-transcriptional regulation in satellite cell activation.

PubMed ID: 23046558

DOI: 10.1186/2044-5040-2-21

PubMed ID: 24733888

Title: Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

PubMed ID: 24733888

DOI: 10.1073/pnas.1320873111

PubMed ID: 25815583

Title: Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.

PubMed ID: 25815583

DOI: 10.7554/elife.03390

PubMed ID: 27193233

Title: Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.

PubMed ID: 27193233

DOI: 10.1007/s00726-016-2261-9

PubMed ID: 26763119

Title: Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.

PubMed ID: 26763119

DOI: 10.1261/rna.054833.115

PubMed ID: 12515557

Title: A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure.

PubMed ID: 12515557

DOI: 10.1021/bi026988m

Sequence Information:

  • Length: 319
  • Mass: 33613
  • Checksum: 860DD6DDA80386F8
  • Sequence:
    • MDLSAIYESL QSMSHDLSSD HGGTESLGGL WNINSDSIPS GVTSRLTGRS TSLVEGRSCG 
WVPPPPGFAP LAPRPGPELS PSPTSPTATP TTSSRYKTEL CRTYSESGRC RYGAKCQFAH 
GLGELRQANR HPKYKTELCH KFYLQGRCPY GSRCHFIHNP TEDLALPGQP HVLRQSISFS 
GLPSGRRSSP PPPGFSGPSL SSCSFSPSSS PPPPGDLPLS PSAFSAAPGT PVTRRDPNQA 
CCPSCRRSTT PSTIWGPLGG LARSPSAHSL GSDPDDYASS GSSLGGSDSP VFEAGVFGPP 
QTPAPPRRLP IFNRISVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.