Details for: Zbtb7b

Gene ID: 22724

Symbol: Zbtb7b

Ensembl ID: ENSMUSG00000028042

Description: zinc finger and BTB domain containing 7B

Associated with

  • Adaptive thermogenesis
    (GO:1990845)
  • Cell differentiation
    (GO:0030154)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna binding
    (GO:0003677)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • Lactation
    (GO:0007595)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043377)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of nk t cell proliferation
    (GO:0051141)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nk t cell differentiation
    (GO:0001865)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of cd4-positive, alpha-beta t cell differentiation
    (GO:0043372)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of srebp signaling pathway
    (GO:2000640)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043376)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of t-helper cell differentiation
    (GO:0045622)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to insulin
    (GO:0032868)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 2139539279

Symbol: ZBT7B_MOUSE

Name: Krueppel-related zinc finger protein cKrox

UniProtKB Accession Codes:

Q64321 Q80VV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 3 Ensembl 4 ExpressionAtlas 1 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 7 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7937772

Title: c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

PubMed ID: 7937772

DOI: 10.1073/pnas.91.20.9372

PubMed ID: 15729333

Title: The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

PubMed ID: 15729333

DOI: 10.1038/nature03338

PubMed ID: 18258917

Title: Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

PubMed ID: 18258917

DOI: 10.1126/science.1151844

PubMed ID: 20810990

Title: p300-mediated acetylation stabilizes the Th-inducing POK factor.

PubMed ID: 20810990

DOI: 10.4049/jimmunol.1001462

PubMed ID: 22730529

Title: Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.

PubMed ID: 22730529

DOI: 10.4049/jimmunol.1201077

PubMed ID: 23105140

Title: ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells.

PubMed ID: 23105140

DOI: 10.4049/jimmunol.1201486

PubMed ID: 23481257

Title: Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus.

PubMed ID: 23481257

DOI: 10.1038/emboj.2013.47

PubMed ID: 24880459

Title: The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.

PubMed ID: 24880459

DOI: 10.1038/ni.2917

PubMed ID: 28784777

Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.

PubMed ID: 28784777

DOI: 10.1073/pnas.1703494114

PubMed ID: 29420538

Title: Th-POK regulates mammary gland lactation through mTOR-SREBP pathway.

PubMed ID: 29420538

DOI: 10.1371/journal.pgen.1007211

Sequence Information:

  • Length: 544
  • Mass: 58918
  • Checksum: 5A43F10AE2970709
  • Sequence:
    • MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 
KLFTEGGGGT VMGTGGGGTA SGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT TTASTSGMPN 
GEDSPPQVPL LPPPPPPPRP VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLTYEEE 
EMVGRLGNSG GSGLGDSYSP PTGAASPAEG PLNYEVFEGE EEEEEMAYPP GYGLAQSNEP 
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL TPGLDGQDKL VRKRRSQMPQ ECPVCHKIIH 
GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH TGERPYSCPH CPARFLHSYD 
LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ RHLKGQNCLE VRTRRRRKDD VAAPHYPPPS 
TTTSSPAGLD LSNGHLDTFH LSLARFWEQS ATTGPPVTTQ GPPEEEEEEG TPTTPQAEGA 
MESS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.