Genular: Defining Cellular Identity and Function

Details for: Zfpm1

Gene ID: 22761

Symbol: Zfpm1

Ensembl ID: ENSMUSG00000049577

Description: zinc finger protein, multitype 1

Associated with

Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hemostasis
(R-MMU-109582)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-MMU-8936459)
Transcriptional regulation by runx1
(R-MMU-8878171)
Atrial septum morphogenesis
(GO:0060413)
Atrioventricular valve morphogenesis
(GO:0003181)
Cardiac muscle tissue morphogenesis
(GO:0055008)
Definitive erythrocyte differentiation
(GO:0060318)
Dna binding
(GO:0003677)
Embryonic hemopoiesis
(GO:0035162)
Erythrocyte differentiation
(GO:0030218)
Granulocyte differentiation
(GO:0030851)
Heart development
(GO:0007507)
Homeostasis of number of cells
(GO:0048872)
Megakaryocyte development
(GO:0035855)
Megakaryocyte differentiation
(GO:0030219)
Metal ion binding
(GO:0046872)
Mitral valve formation
(GO:0003192)
Negative regulation of interleukin-4 production
(GO:0032713)
Negative regulation of mast cell differentiation
(GO:0060377)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Platelet formation
(GO:0030220)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Primitive erythrocyte differentiation
(GO:0060319)
Protein binding
(GO:0005515)
Regulation of chemokine production
(GO:0032642)
Regulation of definitive erythrocyte differentiation
(GO:0010724)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)
Tricuspid valve formation
(GO:0003195)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Zinc finger protein ZFPM1

Genular Protein ID: 3250698921

Symbol: FOG1_MOUSE

Name: Zinc finger protein ZFPM1

UniProtKB Accession Codes:

O35615

Database IDs:

Citations:

PubMed ID: 9230307

Title: FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.

PubMed ID: 9230307

DOI: 10.1016/s0092-8674(00)80318-9

PubMed ID: 9553047

Title: Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.

PubMed ID: 9553047

DOI: 10.1101/gad.12.8.1176

PubMed ID: 9837943

Title: Key residues characteristic of GATA N-fingers are recognized by FOG.

PubMed ID: 9837943

DOI: 10.1074/jbc.273.50.33595

PubMed ID: 10078204

Title: Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.

PubMed ID: 10078204

DOI: 10.1016/s1097-2765(00)80312-3

PubMed ID: 10329627

Title: Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers.

PubMed ID: 10329627

DOI: 10.1093/emboj/18.10.2812

PubMed ID: 11940669

Title: Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.

PubMed ID: 11940669

DOI: 10.1128/mcb.22.9.3121-3128.2002

PubMed ID: 12356738

Title: Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

PubMed ID: 12356738

DOI: 10.1093/emboj/cdf527

PubMed ID: 14614148

Title: Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development.

PubMed ID: 14614148

DOI: 10.1073/pnas.1936250100

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 15234987

Title: A classic zinc finger from Friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3.

PubMed ID: 15234987

DOI: 10.1074/jbc.m404130200

Sequence Information:

Length: 995
Mass: 105984
Checksum: 293255B28151ECB8
Sequence:

MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS PPREDVSPPA 
VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP WSGPEELELA LQDGQRCVRA 
RLSLTEGLSW GPFYGSIQTR ALSPEREEPG PAVTLMVDES CWLRMLPQVL TEEAANSEIY 
RKDDALWCRV TKVVPSGGLL YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG 
MASILATAVI NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP 
NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER HLKVHTDTLS 
GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA GHPAAKLPPD SLAGFQQHSL 
MHSPLVPADK APTPSSGLDS KAEVTNGETR VPPQNGGSSE SPAAPRTIKV EAAEEPEATR 
ASGPGEPGPQ APSRTPSPHS PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD 
AGTTTVPTAP QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN 
NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS SPGPGPREEE 
ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA CNIRFSRHET YTVHKRYYCA 
SRHDPPPRRP PAPTTAPGPA APALTAPPVR TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS 
PTAELPSSPR PGSASAGPAP ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA 
CRVSFHSLEA YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA 
SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP APAPAPGGGG 
GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Zfpm1

Associated with

Other Information

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. PubMed ID: 9230307

Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. PubMed ID: 9553047

Key residues characteristic of GATA N-fingers are recognized by FOG. PubMed ID: 9837943

Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. PubMed ID: 10078204

Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. PubMed ID: 10329627

Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. PubMed ID: 11940669

Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. PubMed ID: 12356738

Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. PubMed ID: 14614148

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A classic zinc finger from Friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. PubMed ID: 15234987