Genular: Defining Cellular Identity and Function

Details for: Zic1

Gene ID: 22771

Symbol: Zic1

Ensembl ID: ENSMUSG00000032368

Description: zinc finger protein of the cerebellum 1

Associated with

Adult walking behavior
(GO:0007628)
Brain development
(GO:0007420)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Central nervous system development
(GO:0007417)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Forebrain development
(GO:0030900)
Gene expression
(GO:0010467)
Hippocampus development
(GO:0021766)
Maintenance of cell number
(GO:0098727)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb development
(GO:0021772)
Pattern specification process
(GO:0007389)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of smoothened signaling pathway
(GO:0008589)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal system development
(GO:0001501)
Spinal cord development
(GO:0021510)

Other Information

Proteins

Zinc finger protein ZIC 1

Genular Protein ID: 159140728

Symbol: ZIC1_MOUSE

Name: Zinc finger protein ZIC 1

UniProtKB Accession Codes:

P46684 Q6PAK5 Q80Y18

Database IDs:

Citations:

PubMed ID: 7931345

Title: A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.

PubMed ID: 7931345

DOI: 10.1046/j.1471-4159.1994.63051880.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11053430

Title: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.

PubMed ID: 11053430

DOI: 10.1074/jbc.m004430200

PubMed ID: 11238441

Title: Physical and functional interactions between Zic and Gli proteins.

PubMed ID: 11238441

DOI: 10.1074/jbc.c000773200

PubMed ID: 11944941

Title: Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation.

PubMed ID: 11944941

DOI: 10.1006/dbio.2002.0598

PubMed ID: 15207726

Title: Myogenic repressor I-mfa interferes with the function of Zic family proteins.

PubMed ID: 15207726

DOI: 10.1016/j.bbrc.2004.05.158

PubMed ID: 19303920

Title: Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.

PubMed ID: 19303920

DOI: 10.1016/j.neuroscience.2009.02.082

PubMed ID: 20354137

Title: Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes.

PubMed ID: 20354137

DOI: 10.1096/fj.09-148908

Sequence Information:

Length: 447
Mass: 48331
Checksum: D41F412F44C2AD3D
Sequence:

MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG 
QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL 
FAASAGGFGG PHGHTDAAGH LLFSGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ 
VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK 
SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK 
PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPTTDNPTTS 
SMSPSSSAVH HTAGHSALSS NFNEWYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Zic1

Associated with

Other Information

A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. PubMed ID: 7931345

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. PubMed ID: 11053430

Physical and functional interactions between Zic and Gli proteins. PubMed ID: 11238441

Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. PubMed ID: 11944941

Myogenic repressor I-mfa interferes with the function of Zic family proteins. PubMed ID: 15207726

Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem. PubMed ID: 19303920

Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes. PubMed ID: 20354137