Genular: Defining Cellular Identity and Function

Details for: Ikzf3

Gene ID: 22780

Symbol: Ikzf3

Ensembl ID: ENSMUSG00000018168

Description: IKAROS family zinc finger 3

Associated with

B cell activation
(GO:0042113)
B cell differentiation
(GO:0030183)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic process
(GO:0042981)
Regulation of b cell differentiation
(GO:0045577)
Regulation of b cell proliferation
(GO:0030888)
Regulation of lymphocyte differentiation
(GO:0045619)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to bacterium
(GO:0009617)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
T cell differentiation
(GO:0030217)

Other Information

Proteins

Zinc finger protein Aiolos

Genular Protein ID: 854927947

Symbol: IKZF3_MOUSE

Name: Zinc finger protein Aiolos

UniProtKB Accession Codes:

O08900 B1AQE6

Database IDs:

Citations:

PubMed ID: 9155026

Title: Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.

PubMed ID: 9155026

DOI: 10.1093/emboj/16.8.2004

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9806640

Title: Aiolos regulates B cell activation and maturation to effector state.

PubMed ID: 9806640

DOI: 10.1016/s1074-7613(00)80637-8

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 34155405

Title: A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.

PubMed ID: 34155405

DOI: 10.1038/s41590-021-00951-z

Sequence Information:

Length: 507
Mass: 57967
Checksum: 103D46D0C6E236F7
Sequence:

MEDIQPTVEL KSTEEQPLPT ESPDALNDYS LPKPHEIENV DSREAPANED EDAGEDSMKV 
KDEYSDRDEN IMKPEPMGDA EESEMPYSYA REYSDYESIK LERHVPYDNS RPTGGKMNCD 
VCGLSCISFN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHTGE KPFKCHLCNY 
ACQRRDALTG HLRTHSVEKP YKCEFCGRSY KQRSSLEEHK ERCRAFLQNP DLGDAASVEA 
RHIKAEMGSE RALVLDRLAS NVAKRKSSMP QKFIGEKRHC FDANYNPGYM YEKENEMMQT 
RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSV YPIALTRADM PNGAPQEMEK 
KRILLPEKIL PSERGLSPNN SAQDSTDTDS NHEDRQHLYQ QSHVVLPQAR NGMPLLKEVP 
RSFELLKPPP ICLRDSIKVI NKEGEVMDVF RCDHCHVLFL DYVMFTIHMG CHGFRDPFEC 
NMCGYRSHDR YEFSSHIARG EHRAMLK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ikzf3

Associated with

Other Information

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. PubMed ID: 9155026

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Aiolos regulates B cell activation and maturation to effector state. PubMed ID: 9806640