RRAS2 | ENSG00000133818 | NCBI 22800

Details for: RRAS2

Gene ID: 22800

Symbol: RRAS2

Ensembl ID: ENSG00000133818

Description: RAS related 2

Associated with

Rho gtpase cycle
(R-HSA-9012999)
Rnd1 gtpase cycle
(R-HSA-9696273)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Gdp binding
(GO:0019003)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Membrane
(GO:0016020)
Osteoblast differentiation
(GO:0001649)
Plasma membrane
(GO:0005886)
Positive regulation of schwann cell migration
(GO:1900149)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Schwann cell migration
(GO:0036135)

Other Information

Proteins

Ras-related protein R-Ras2

Genular Protein ID: 1895638431

Symbol: RRAS2_HUMAN

Name: Ras-related protein R-Ras2

UniProtKB Accession Codes:

P62070 B2R9Z3 B7Z5Z2 B7Z6C4 B7Z7H6 P17082

Database IDs:

Citations:

PubMed ID: 2108320

Title: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

PubMed ID: 2108320

DOI: 10.1128/mcb.10.4.1793-1798.1990

PubMed ID: 8052619

Title: A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.

PubMed ID: 8052619

DOI: 10.1073/pnas.91.16.7558

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15308774

Title: A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

PubMed ID: 15308774

DOI: 10.1073/pnas.0403413101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31130282

Title: Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.

PubMed ID: 31130282

DOI: 10.1016/j.ajhg.2019.04.013

PubMed ID: 31130285

Title: Germline-Activating RRAS2 Mutations Cause Noonan Syndrome.

PubMed ID: 31130285

DOI: 10.1016/j.ajhg.2019.04.014

PubMed ID: 28406396

Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.

PubMed ID: 28406396

DOI: 10.7554/elife.25158

Sequence Information:

Length: 204
Mass: 23400
Checksum: BA7D4759DC49446F
Sequence:

MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR 
AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF 
PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE 
QECPPSPEPT RKEKDKKGCH CVIF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RRAS2

Associated with

Other Information

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. PubMed ID: 2108320

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. PubMed ID: 8052619

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. PubMed ID: 15308774

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. PubMed ID: 31130282

Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. PubMed ID: 31130285

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. PubMed ID: 28406396