Details for: RRAS2

Gene ID: 22800

Symbol: RRAS2

Ensembl ID: ENSG00000133818

Description: RAS related 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.47
    Marker Score: 59,437
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.54
    Marker Score: 2,268
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.3
    Marker Score: 1,119
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.12
    Marker Score: 1,700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.68
    Marker Score: 25,078
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.67
    Marker Score: 1,761
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.67
    Marker Score: 15,708
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6
    Marker Score: 6,191
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.59
    Marker Score: 3,875
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.53
    Marker Score: 2,576
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.53
    Marker Score: 4,222
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.51
    Marker Score: 57,163
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,185
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.45
    Marker Score: 11,078
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12,295
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,162
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.39
    Marker Score: 1,737
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.39
    Marker Score: 405
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.38
    Marker Score: 841
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.38
    Marker Score: 4,899
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.38
    Marker Score: 770
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.34
    Marker Score: 1,319
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.33
    Marker Score: 1,473
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.33
    Marker Score: 81,885
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.24
    Marker Score: 1,299
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.24
    Marker Score: 977
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.21
    Marker Score: 388
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2
    Marker Score: 3,569
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,800
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.2
    Marker Score: 296
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.19
    Marker Score: 11,348
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.19
    Marker Score: 4,983
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.16
    Marker Score: 25,974
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.16
    Marker Score: 676
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.15
    Marker Score: 1,844
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.14
    Marker Score: 762
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.08
    Marker Score: 2,545
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.08
    Marker Score: 2,258
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.07
    Marker Score: 597
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1,149
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.05
    Marker Score: 700
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.03
    Marker Score: 373
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.02
    Marker Score: 20,363
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.02
    Marker Score: 1,773
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.01
    Marker Score: 359
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.01
    Marker Score: 1,353
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 604
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1
    Marker Score: 1,926
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 372
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Marker Score: 3,518
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.99
    Marker Score: 486
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.98
    Marker Score: 590
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1,014
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.96
    Marker Score: 240
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.96
    Marker Score: 240
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.94
    Marker Score: 549
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.94
    Marker Score: 4,594
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.91
    Marker Score: 3,525
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.91
    Marker Score: 334
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.91
    Marker Score: 5,870
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.91
    Marker Score: 31,612
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3,935
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.91
    Marker Score: 240
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.91
    Marker Score: 1,143
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.9
    Marker Score: 337
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.9
    Marker Score: 305
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9
    Marker Score: 2,242
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 522
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.89
    Marker Score: 3,507
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.89
    Marker Score: 369
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.88
    Marker Score: 326
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.88
    Marker Score: 253
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.87
    Marker Score: 933
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.87
    Marker Score: 207
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.86
    Marker Score: 764
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29,103
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,880
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.85
    Marker Score: 1,029
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,364
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.84
    Marker Score: 713
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.84
    Marker Score: 284
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.84
    Marker Score: 582
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.83
    Marker Score: 240
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.83
    Marker Score: 357
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.82
    Marker Score: 452
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.82
    Marker Score: 1,862
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.82
    Marker Score: 314
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.81
    Marker Score: 187
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.81
    Marker Score: 5,289
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.81
    Marker Score: 689
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.8
    Marker Score: 280
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.8
    Marker Score: 1,150

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRAS2 is a small GTPase that belongs to the RAS superfamily, which consists of three main subfamilies: RAS, RHO, and RAB. RRAS2 is specifically involved in the RHO GTPase cycle, which regulates actin cytoskeleton reorganization, cell migration, and cell cycle progression. It is characterized by its ability to bind GDP and GTP, and its interaction with downstream effectors, such as Rho GTPases and Rnd1 GTPases. **Pathways and Functions:** RRAS2 is involved in various signaling pathways, including: 1. **Focal Adhesion**: RRAS2 regulates the formation and disassembly of focal adhesions, which are critical for cell migration and invasion. 2. **GTPase Activity**: RRAS2's GTPase activity regulates the activation and inactivation of downstream effectors, including Rho GTPases and Rnd1 GTPases. 3. **Osteoblast Differentiation**: RRAS2 is involved in the regulation of osteoblast differentiation, which is essential for bone formation and remodeling. 4. **Schwann Cell Migration**: RRAS2 regulates the migration of Schwann cells, which are essential for nerve regeneration and repair. **Clinical Significance:** RRAS2 has been implicated in various diseases, including: 1. **Cancer**: RRAS2 mutations have been associated with several types of cancer, including colorectal, breast, and lung cancer. 2. **Cardiovascular Disease**: RRAS2 has been implicated in the regulation of cardiac muscle cell function and the development of cardiovascular disease. 3. **Neurological Disorders**: RRAS2 has been associated with neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Inflammatory Diseases**: RRAS2 has been implicated in the regulation of inflammatory responses and the development of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. **Conclusion:** In conclusion, RRAS2 is a critical regulator of cellular signaling pathways, including focal adhesion, GTPase activity, osteoblast differentiation, and Schwann cell migration. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, neurological disorders, and inflammatory diseases. Further research is necessary to elucidate the molecular mechanisms underlying RRAS2's role in disease pathogenesis and to develop therapeutic strategies targeting this gene. **Recommendations:** 1. **Immunohistochemical Analysis**: Conduct immunohistochemical analysis to investigate the expression of RRAS2 in various tissues and cells. 2. **Cell Culture Studies**: Perform cell culture studies to investigate the role of RRAS2 in regulating cell migration, invasion, and differentiation. 3. **Mouse Models**: Develop mouse models to investigate the role of RRAS2 in disease pathogenesis and to test the efficacy of therapeutic strategies targeting this gene. 4. **Clinical Trials**: Conduct clinical trials to investigate the efficacy and safety of therapeutic strategies targeting RRAS2 in human diseases.

Genular Protein ID: 1895638431

Symbol: RRAS2_HUMAN

Name: Ras-related protein R-Ras2

UniProtKB Accession Codes:

P62070 B2R9Z3 B7Z5Z2 B7Z6C4 B7Z7H6 P17082

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2108320

Title: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

PubMed ID: 2108320

DOI: 10.1128/mcb.10.4.1793-1798.1990

PubMed ID: 8052619

Title: A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.

PubMed ID: 8052619

DOI: 10.1073/pnas.91.16.7558

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15308774

Title: A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

PubMed ID: 15308774

DOI: 10.1073/pnas.0403413101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31130282

Title: Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.

PubMed ID: 31130282

DOI: 10.1016/j.ajhg.2019.04.013

PubMed ID: 31130285

Title: Germline-Activating RRAS2 Mutations Cause Noonan Syndrome.

PubMed ID: 31130285

DOI: 10.1016/j.ajhg.2019.04.014

PubMed ID: 28406396

Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.

PubMed ID: 28406396

DOI: 10.7554/elife.25158

Sequence Information:

  • Length: 204
  • Mass: 23400
  • Checksum: BA7D4759DC49446F
  • Sequence:
    • MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR 
AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF 
PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE 
QECPPSPEPT RKEKDKKGCH CVIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.