MRAS | ENSG00000158186 | NCBI 22808

Details for: MRAS

Gene ID: 22808

Symbol: MRAS

Ensembl ID: ENSG00000158186

Description: muscle RAS oncogene homolog

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Gdp binding
(GO:0019003)
G protein activity
(GO:0003925)
Gtp-dependent protein binding
(GO:0030742)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)

Other Information

Proteins

Ras-related protein M-Ras
Q8WVM9_HUMAN

Genular Protein ID: 908563762

Symbol: RASM_HUMAN

Name: Ras-related protein M-Ras

UniProtKB Accession Codes:

O14807 B4DIK0 Q86WX8

Database IDs:

Citations:

PubMed ID: 9400994

Title: Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution.

PubMed ID: 9400994

DOI: 10.1038/sj.onc.1201674

PubMed ID: 10477695

Title: Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones.

PubMed ID: 10477695

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 16630891

Title: A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

PubMed ID: 16630891

DOI: 10.1016/j.molcel.2006.03.027

PubMed ID: 28289718

Title: Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.

PubMed ID: 28289718

DOI: 10.1172/jci.insight.91225

PubMed ID: 31173466

Title: Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers.

PubMed ID: 31173466

DOI: 10.1002/ajmg.a.61261

Sequence Information:

Length: 208
Mass: 23846
Checksum: 0B2B55AFA96B3EC4
Sequence:

MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW 
AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP 
MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP 
EKSQKKKKKT KWRGDRATGT HKLQCVIL

Genular Protein ID: 3963626185

Symbol: Q8WVM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WVM9

Database IDs:

Sequence Information:

Length: 64
Mass: 7482
Checksum: 03E7B04ACDA42137
Sequence:

WETWLATPHH DRGANWDFWL FDILMFPLVF RRIVLPSHPL EHSLPEMPSP HAFAIVCSQI 
SSTV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MRAS

Associated with

Other Information

Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. PubMed ID: 9400994

Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. PubMed ID: 10477695

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. PubMed ID: 16630891

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. PubMed ID: 28289718

Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers. PubMed ID: 31173466