ATF5 | ENSG00000169136 | NCBI 22809

Details for: ATF5

Gene ID: 22809

Symbol: ATF5

Ensembl ID: ENSG00000169136

Description: activating transcription factor 5

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Centrosome
(GO:0005813)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Circadian rhythm
(GO:0007623)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Fat cell differentiation
(GO:0045444)
Kinase binding
(GO:0019900)
Multicellular organism growth
(GO:0035264)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell cycle g2/m phase transition
(GO:1902750)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb interneuron development
(GO:0021891)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Regulation of centrosome cycle
(GO:0046605)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Tubulin binding
(GO:0015631)

Other Information

Proteins

Cyclic AMP-dependent transcription factor ATF-5

Genular Protein ID: 2849279394

Symbol: ATF5_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-5

UniProtKB Accession Codes:

Q9Y2D1 B3KND3 Q9BSA1 Q9UNQ3

Database IDs:

Citations:

PubMed ID: 11087824

Title: The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.

PubMed ID: 11087824

DOI: 10.1073/pnas.240452197

PubMed ID: 15221005

Title: Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.

PubMed ID: 15221005

DOI: 10.1038/sj.onc.1207782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373550

Title: Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.

PubMed ID: 10373550

DOI: 10.1128/mcb.19.7.5001

PubMed ID: 15358120

Title: Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.

PubMed ID: 15358120

DOI: 10.1016/j.bbrc.2004.07.053

PubMed ID: 18701499

Title: Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest.

PubMed ID: 18701499

DOI: 10.1158/0008-5472.can-07-6469

PubMed ID: 18332083

Title: ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.

PubMed ID: 18332083

DOI: 10.1124/dmd.107.019380

PubMed ID: 18458088

Title: Cdc34-mediated degradation of ATF5 is blocked by cisplatin.

PubMed ID: 18458088

DOI: 10.1074/jbc.m707879200

PubMed ID: 20654631

Title: Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells.

PubMed ID: 20654631

DOI: 10.1016/j.lfs.2010.07.006

PubMed ID: 21212266

Title: BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.

PubMed ID: 21212266

DOI: 10.1074/jbc.m110.207639

PubMed ID: 21791614

Title: p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.

PubMed ID: 21791614

DOI: 10.1128/mcb.05887-11

PubMed ID: 22528486

Title: Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

PubMed ID: 22528486

DOI: 10.1074/jbc.m112.363622

PubMed ID: 22442021

Title: ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells.

PubMed ID: 22442021

DOI: 10.1002/jcb.24150

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24379400

Title: N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1beta (IL-1beta)-induced stabilization.

PubMed ID: 24379400

DOI: 10.1074/jbc.m113.491217

PubMed ID: 24216764

Title: p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation.

PubMed ID: 24216764

DOI: 10.1128/mcb.00956-13

PubMed ID: 26213385

Title: ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.

PubMed ID: 26213385

DOI: 10.1016/j.cell.2015.06.055

PubMed ID: 25512613

Title: Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway.

PubMed ID: 25512613

DOI: 10.1128/mcb.01228-14

Sequence Information:

Length: 282
Mass: 30674
Checksum: DDB2F907CA0215A0
Sequence:

MSLLATLGLE LDRALLPASG LGWLVDYGKL PPAPAPLAPY EVLGGALEGG LPVGGEPLAG 
DGFSDWMTER VDFTALLPLE PPLPPGTLPQ PSPTPPDLEA MASLLKKELE QMEDFFLDAP 
PLPPPSPPPL PPPPLPPAPS LPLSLPSFDL PQPPVLDTLD LLAIYCRNEA GQEEVGMPPL 
PPPQQPPPPS PPQPSRLAPY PHPATTRGDR KQKKRDQNKS AALRYRQRKR AEGEALEGEC 
QGLEARNREL KERAESVERE IQYVKDLLIE VYKARSQRTR SC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATF5

Associated with

Other Information

The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. PubMed ID: 11087824

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. PubMed ID: 15221005

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. PubMed ID: 10373550

Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. PubMed ID: 15358120

Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest. PubMed ID: 18701499

ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. PubMed ID: 18332083

Cdc34-mediated degradation of ATF5 is blocked by cisplatin. PubMed ID: 18458088

Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells. PubMed ID: 20654631

BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. PubMed ID: 21212266

p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. PubMed ID: 21791614

Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells. PubMed ID: 22528486

ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells. PubMed ID: 22442021

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1beta (IL-1beta)-induced stabilization. PubMed ID: 24379400

p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation. PubMed ID: 24216764

ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. PubMed ID: 26213385

Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway. PubMed ID: 25512613