PPM1E | ENSG00000175175 | NCBI 22843

Details for: PPM1E

Gene ID: 22843

Symbol: PPM1E

Ensembl ID: ENSG00000175175

Description: protein phosphatase, Mg2+/Mn2+ dependent 1E

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Transmission across chemical synapses
(R-HSA-112315)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytoplasm
(GO:0005737)
Metal ion binding
(GO:0046872)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of protein kinase activity
(GO:0006469)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Positive regulation of stress fiber assembly
(GO:0051496)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine phosphatase activity
(GO:0004722)

Other Information

Proteins

Protein phosphatase 1E

Genular Protein ID: 2016400352

Symbol: PPM1E_HUMAN

Name: Protein phosphatase 1E

UniProtKB Accession Codes:

Q8WY54 A7E2X1 Q68DW1 Q7LAF3 Q9UPT0

Database IDs:

Citations:

PubMed ID: 11864573

Title: The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.

PubMed ID: 11864573

DOI: 10.1016/s0960-9822(02)00652-8

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15496589

Title: Identification and characterization of nuclear localization signals of CaMKP-N.

PubMed ID: 15496589

DOI: 10.1093/jb/mvh109

PubMed ID: 16269004

Title: Post-translational excision of the carboxyl-terminal segment of CaM kinase phosphatase N and its cytosolic occurrence in the brain.

PubMed ID: 16269004

DOI: 10.1111/j.1471-4159.2005.03540.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 755
Mass: 83952
Checksum: C24C64A0A1BC1091
Sequence:

MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPEPEPE PEPESEPEPE PELVEAEAAE 
ASVEEPGEEA ATVAATEEGD QEQDPEPEEE AAVEGEEEEE GAATAAAAPG HSAVPPPPPQ 
LPPLPPLPRP LSERITREEV EGESLDLCLQ QLYKYNCPSF LAAALARATS DEVLQSDLSA 
HYIPKETDGT EGTVEIETVK LARSVFSKLH EICCSWVKDF PLRRRPQLYY ETSIHAIKNM 
RRKMEDKHVC IPDFNMLFNL EDQEEQAYFA VFDGHGGVDA AIYASIHLHV NLVRQEMFPH 
DPAEALCRAF RVTDERFVQK AARESLRCGT TGVVTFIRGN MLHVAWVGDS QVMLVRKGQA 
VELMKPHKPD REDEKQRIEA LGGCVVWFGA WRVNGSLSVS RAIGDAEHKP YICGDADSAS 
TVLDGTEDYL ILACDGFYDT VNPDEAVKVV SDHLKENNGD SSMVAHKLVA SARDAGSSDN 
ITVIVVFLRD MNKAVNVSEE SDWTENSFQG GQEDGGDDKE NHGECKRPWP QHQCSAPADL 
GYDGRVDSFT DRTSLSPGSQ INVLEDPGYL DLTQIEASKP HSAQFLLPVE MFGPGAPKKA 
NLINELMMEK KSVQSSLPEW SGAGEFPTAF NLGSTGEQIY RMQSLSPVCS GLENEQFKSP 
GNRVSRLSHL RHHYSKKWHR FRFNPKFYSF LSAQEPSHKI GTSLSSLTGS GKRNRIRSSL 
PWRQNSWKGY SENMRKLRKT HDIPCPDLPW SYKIE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPM1E

Associated with

Other Information

The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. PubMed ID: 11864573

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10470851

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. PubMed ID: 16344560

Identification and characterization of nuclear localization signals of CaMKP-N. PubMed ID: 15496589

Post-translational excision of the carboxyl-terminal segment of CaM kinase phosphatase N and its cytosolic occurrence in the brain. PubMed ID: 16269004

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974