Details for: NLRP1

Gene ID: 22861

Symbol: NLRP1

Ensembl ID: ENSG00000091592

Description: NLR family pyrin domain containing 1

Associated with

Other Information

Genular Protein ID: 1855311348

Symbol: NLRP1_HUMAN

Name: Caspase recruitment domain-containing protein 7

UniProtKB Accession Codes:

Q9C000 E9PE50 I6L9D9 Q9BZZ8 Q9BZZ9 Q9H5Z7 Q9H5Z8 Q9HAV8 Q9UFT4 Q9Y2E0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 12 EMDB 5 EPD 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 MANE-Select 1 MEROPS 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 5 Rhea 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11270363

Title: The PYRIN domain: a novel motif found in apoptosis and inflammation proteins.

PubMed ID: 11270363

DOI: 10.1038/sj.cdd.4400774

PubMed ID: 11250163

Title: The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.

PubMed ID: 11250163

DOI: 10.1016/s0960-9822(01)00056-2

PubMed ID: 11076957

Title: Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins.

PubMed ID: 11076957

DOI: 10.1074/jbc.m009853200

PubMed ID: 11113115

Title: A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.

PubMed ID: 11113115

DOI: 10.1074/jbc.m006309200

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 22665479

Title: Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity.

PubMed ID: 22665479

DOI: 10.1074/jbc.m112.378323

PubMed ID: 12191486

Title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

PubMed ID: 12191486

DOI: 10.1016/s1097-2765(02)00599-3

PubMed ID: 15285719

Title: NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells.

PubMed ID: 15285719

DOI: 10.1042/bj20040867

PubMed ID: 15212762

Title: Expression of NALP1 in cerebellar granule neurons stimulates apoptosis.

PubMed ID: 15212762

DOI: 10.1016/j.cellsig.2004.02.006

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 17431422

Title: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

PubMed ID: 17431422

DOI: 10.1038/sj.cdd.4402142

PubMed ID: 17164409

Title: Inflammasome components NALP 1 and 3 Show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.

PubMed ID: 17164409

DOI: 10.1369/jhc.6a7101.2006

PubMed ID: 17349957

Title: Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.

PubMed ID: 17349957

DOI: 10.1016/j.molcel.2007.01.032

PubMed ID: 18511561

Title: A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.

PubMed ID: 18511561

DOI: 10.1073/pnas.0802726105

PubMed ID: 32558991

Title: The NLRP1 and CARD8 inflammasomes.

PubMed ID: 32558991

DOI: 10.1111/imr.12884

PubMed ID: 19651869

Title: Expression of Nlrp1b inflammasome components in human fibroblasts confers susceptibility to anthrax lethal toxin.

PubMed ID: 19651869

DOI: 10.1128/iai.00276-09

PubMed ID: 22087307

Title: CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.

PubMed ID: 22087307

DOI: 10.1371/journal.pone.0027396

PubMed ID: 22801494

Title: Novel role of PKR in inflammasome activation and HMGB1 release.

PubMed ID: 22801494

DOI: 10.1038/nature11290

PubMed ID: 16439990

Title: Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.

PubMed ID: 16439990

DOI: 10.1038/sj.cdd.4401853

PubMed ID: 24439873

Title: NLRP1 inflammasome, and not NLRP3, is the key in the shift to proinflammatory state on endothelial cells in peripheral arterial disease.

PubMed ID: 24439873

DOI: 10.1016/j.ijcard.2013.12.201

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 25562666

Title: Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes.

PubMed ID: 25562666

DOI: 10.1038/jid.2014.551

PubMed ID: 26086088

Title: Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress.

PubMed ID: 26086088

DOI: 10.1371/journal.pone.0130635

PubMed ID: 30291141

Title: Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

PubMed ID: 30291141

DOI: 10.1074/jbc.ra118.004350

PubMed ID: 30096351

Title: Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing.

PubMed ID: 30096351

DOI: 10.1016/j.jid.2018.07.016

PubMed ID: 31525884

Title: DPP9's enzymatic activity and not its binding to CARD8 inhibits inflammasome activation.

PubMed ID: 31525884

DOI: 10.1021/acschembio.9b00462

PubMed ID: 32051255

Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.

PubMed ID: 32051255

DOI: 10.26508/lsa.202000664

PubMed ID: 33243852

Title: Human NLRP1 is a sensor for double-stranded RNA.

PubMed ID: 33243852

DOI: 10.1126/science.abd0811

PubMed ID: 33852854

Title: Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

PubMed ID: 33852854

DOI: 10.1016/j.celrep.2021.108998

PubMed ID: 33410748

Title: Diverse viral proteases activate the NLRP1 inflammasome.

PubMed ID: 33410748

DOI: 10.7554/elife.60609

PubMed ID: 35594856

Title: Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.

PubMed ID: 35594856

DOI: 10.1016/j.molcel.2022.04.033

PubMed ID: 33731929

Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.

PubMed ID: 33731929

DOI: 10.1038/s41586-021-03320-w

PubMed ID: 35618833

Title: KSHV-encoded ORF45 activates human NLRP1 inflammasome.

PubMed ID: 35618833

DOI: 10.1038/s41590-022-01199-x

PubMed ID: 35857590

Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.

PubMed ID: 35857590

DOI: 10.1126/science.abl6324

PubMed ID: 14527388

Title: NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.

PubMed ID: 14527388

DOI: 10.1016/j.str.2003.08.009

PubMed ID: 33731932

Title: DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.

PubMed ID: 33731932

DOI: 10.1038/s41586-021-03350-4

PubMed ID: 33420028

Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.

PubMed ID: 33420028

DOI: 10.1038/s41467-020-20319-5

PubMed ID: 33420033

Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.

PubMed ID: 33420033

DOI: 10.1038/s41467-020-20320-y

PubMed ID: 17377159

Title: NALP1 in vitiligo-associated multiple autoimmune disease.

PubMed ID: 17377159

DOI: 10.1056/nejmoa061592

PubMed ID: 23349227

Title: Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.

PubMed ID: 23349227

DOI: 10.1136/jmedgenet-2012-101325

PubMed ID: 27662089

Title: Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation.

PubMed ID: 27662089

DOI: 10.1016/j.cell.2016.09.001

PubMed ID: 27965258

Title: A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis).

PubMed ID: 27965258

DOI: 10.1136/annrheumdis-2016-210021

PubMed ID: 31484767

Title: Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis.

PubMed ID: 31484767

DOI: 10.1073/pnas.1906184116

PubMed ID: 33093214

Title: Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.

PubMed ID: 33093214

DOI: 10.1126/science.aay2002

Sequence Information:

  • Length: 1473
  • Mass: 165866
  • Checksum: 438F0DCE45C2562D
  • Sequence:
    • MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG MEVASYLVAQ 
YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW 
IHELPAGCTQ GSERRVLRQL PDTSGRRWRE ISASLLYQAL PSSPDHESPS QESPNAPTST 
AVLGSWGSPP QPSLAPREQE APGTQWPLDE TSGIYYTEIR EREREKSEKG RPPWAAVVGT 
PPQAHTSLQP HHHPWEPSVR ESLCSTWPWK NEDFNQKFTQ LLLLQRPHPR SQDPLVKRSW 
PDYVEENRGH LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVKEA WGRGQLYGDR 
FQHVFYFSCR ELAQSKVVSL AELIGKDGTA TPAPIRQILS RPERLLFILD GVDEPGWVLQ 
EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG 
FSESSRKEYF YRYFTDERQA IRAFRLVKSN KELWALCLVP WVSWLACTCL MQQMKRKEKL 
TLTSKTTTTL CLHYLAQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI 
ISTFLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYVLEDE KGRGKHSNCI IDLEKTLEAY 
GIHGLFGAST TRFLLGLLSD EGEREMENIF HCRLSQGRNL MQWVPSLQLL LQPHSLESLH 
CLYETRNKTF LTQVMAHFEE MGMCVETDME LLVCTFCIKF SRHVKKLQLI EGRQHRSTWS 
PTMVVLFRWV PVTDAYWQIL FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE 
TLRLAGCGLT AEDCKDLAFG LRANQTLTEL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ 
LVSCGLTSDC CQDLASVLSA SPSLKELDLQ QNNLDDVGVR LLCEGLRHPA CKLIRLGLDQ 
TTLSDEMRQE LRALEQEKPQ LLIFSRRKPS VMTPTEGLDT GEMSNSTSSL KRQRLGSERA 
ASHVAQANLK LLDVSKIFPI AEIAEESSPE VVPVELLCVP SPASQGDLHT KPLGTDDDFW 
GPTGPVATEV VDKEKNLYRV HFPVAGSYRW PNTGLCFVMR EAVTVEIEFC VWDQFLGEIN 
PQHSWMVAGP LLDIKAEPGA VEAVHLPHFV ALQGGHVDTS LFQMAHFKEE GMLLEKPARV 
ELHHIVLENP SFSPLGVLLK MIHNALRFIP VTSVVLLYHR VHPEEVTFHL YLIPSDCSIR 
KAIDDLEMKF QFVRIHKPPP LTPLYMGCRY TVSGSGSGML EILPKELELC YRSPGEDQLF 
SEFYVGHLGS GIRLQVKDKK DETLVWEALV KPGDLMPATT LIPPARIAVP SPLDAPQLLH 
FVDQYREQLI ARVTSVEVVL DKLHGQVLSQ EQYERVLAEN TRPSQMRKLF SLSQSWDRKC 
KDGLYQALKE THPHLIMELW EKGSKKGLLP LSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.