ATG14 | ENSG00000126775 | NCBI 22863

Details for: ATG14

Gene ID: 22863

Symbol: ATG14

Ensembl ID: ENSG00000126775

Description: autophagy related 14

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Autophagy
(R-HSA-9612973)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Autophagosome
(GO:0005776)
Autophagosome assembly
(GO:0000045)
Autophagosome maturation
(GO:0097352)
Autophagosome membrane
(GO:0000421)
Autophagosome membrane docking
(GO:0016240)
Axoneme
(GO:0005930)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to starvation
(GO:0009267)
Cytosol
(GO:0005829)
Early endosome to late endosome transport
(GO:0045022)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome to lysosome transport
(GO:0008333)
Extrinsic component of omegasome membrane
(GO:0097629)
Extrinsic component of phagophore assembly site membrane
(GO:0097632)
Gtpase binding
(GO:0051020)
Macroautophagy
(GO:0016236)
Mitochondria-associated endoplasmic reticulum membrane
(GO:0044233)
Mitophagy
(GO:0000423)
Negative regulation of protein phosphorylation
(GO:0001933)
Phagocytic vesicle
(GO:0045335)
Phagophore assembly site
(GO:0000407)
Phagophore assembly site membrane
(GO:0034045)
Phosphatidylinositol-3-phosphate biosynthetic process
(GO:0036092)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase complex, class iii
(GO:0035032)
Phosphatidylinositol 3-kinase inhibitor activity
(GO:0141039)
Positive regulation of protein phosphorylation
(GO:0001934)
Post-transcriptional regulation of gene expression
(GO:0010608)
Protein-membrane adaptor activity
(GO:0043495)
Protein binding
(GO:0005515)
Protein targeting to lysosome
(GO:0006622)
Regulation of macroautophagy
(GO:0016241)
Regulation of protein complex stability
(GO:0061635)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of triglyceride metabolic process
(GO:0090207)
Response to mitochondrial depolarisation
(GO:0098780)

Other Information

Proteins

BAKOR_HUMAN

Genular Protein ID: 188458791

Symbol: BAKOR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZNE5 A6NJE4 A8K9U5 B7ZWP5 O94920 Q32MK7 Q32MK8

Database IDs:

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18843052

Title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

PubMed ID: 18843052

DOI: 10.1091/mbc.e08-01-0080

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19050071

Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

PubMed ID: 19050071

DOI: 10.1073/pnas.0810452105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 20713597

Title: Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

PubMed ID: 20713597

DOI: 10.1083/jcb.200911141

PubMed ID: 22314358

Title: Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.

PubMed ID: 22314358

DOI: 10.1038/ncomms1648

PubMed ID: 23954414

Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

PubMed ID: 23954414

DOI: 10.1016/j.cell.2013.07.035

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 25490155

Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

PubMed ID: 25490155

DOI: 10.7554/elife.05115

PubMed ID: 25686604

Title: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

PubMed ID: 25686604

DOI: 10.1038/nature14147

PubMed ID: 28218432

Title: BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.

PubMed ID: 28218432

DOI: 10.1002/pro.3140

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 31123703

Title: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.

PubMed ID: 31123703

DOI: 10.1126/sciadv.aau8857

PubMed ID: 32690950

Title: STEEP mediates STING ER exit and activation of signaling.

PubMed ID: 32690950

DOI: 10.1038/s41590-020-0730-5

PubMed ID: 32929276

Title:

PubMed ID: 32929276

DOI: 10.1038/s41590-020-0803-5

PubMed ID: 37632749

Title: MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.

PubMed ID: 37632749

DOI: 10.1016/j.celrep.2023.113045

Sequence Information:

Length: 492
Mass: 55309
Checksum: A3EAB0580077D7A6
Sequence:

MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ 
SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI 
EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT 
IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA 
RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA 
YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF 
SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG 
DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS 
VTSWFKAYTG HR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATG14

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. PubMed ID: 18843052

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. PubMed ID: 19050071

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. PubMed ID: 19270696

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. PubMed ID: 20713597

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. PubMed ID: 22314358

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. PubMed ID: 23954414

Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. PubMed ID: 23878393

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. PubMed ID: 25490155

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. PubMed ID: 25686604

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. PubMed ID: 28218432

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. PubMed ID: 31806350

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. PubMed ID: 31123703

STEEP mediates STING ER exit and activation of signaling. PubMed ID: 32690950