FASTKD2 | ENSG00000118246 | NCBI 22868

Details for: FASTKD2

Gene ID: 22868

Symbol: FASTKD2

Ensembl ID: ENSG00000118246

Description: FAST kinase domains 2

Associated with

Fastk family proteins regulate processing and stability of mitochondrial rnas
(R-HSA-9837092)
Metabolism of rna
(R-HSA-8953854)
Mitochondrial rna degradation
(R-HSA-9836573)
Apoptotic process
(GO:0006915)
Mitochondrial large ribosomal subunit assembly
(GO:1902775)
Mitochondrial matrix
(GO:0005759)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrial rna processing
(GO:0000963)
Mitochondrial translation
(GO:0032543)
Mitochondrion
(GO:0005739)
Positive regulation of mitochondrial translation
(GO:0070131)
Protein binding
(GO:0005515)
Regulation of mitochondrial mrna stability
(GO:0044528)
Ribonucleoprotein granule
(GO:0035770)
Rna binding
(GO:0003723)
Rna processing
(GO:0006396)
Rrna binding
(GO:0019843)

Other Information

Proteins

FAST kinase domain-containing protein 2, mitochondrial

Genular Protein ID: 1401581205

Symbol: FAKD2_HUMAN

Name: FAST kinase domain-containing protein 2, mitochondrial

UniProtKB Accession Codes:

Q9NYY8 Q9NVX6 Q9Y2H7

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18771761

Title: FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency.

PubMed ID: 18771761

DOI: 10.1016/j.ajhg.2008.08.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20869947

Title: Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.

PubMed ID: 20869947

DOI: 10.1016/j.bbrc.2010.09.075

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25683715

Title: Mitochondrial RNA granules are centers for post-transcriptional RNA processing and ribosome biogenesis.

PubMed ID: 25683715

DOI: 10.1016/j.celrep.2015.01.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26370583

Title: FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.

PubMed ID: 26370583

DOI: 10.1261/rna.052365.115

PubMed ID: 27667664

Title: A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

PubMed ID: 27667664

DOI: 10.1016/j.cmet.2016.08.017

PubMed ID: 28499982

Title: Identification of FASTKD2 compound heterozygous mutations as the underlying cause of autosomal recessive MELAS-like syndrome.

PubMed ID: 28499982

DOI: 10.1016/j.mito.2017.05.005

PubMed ID: 31944455

Title: Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency.

PubMed ID: 31944455

DOI: 10.1002/humu.23985

Sequence Information:

Length: 710
Mass: 81463
Checksum: 11BF1D5A0CF1DA15
Sequence:

MLTTLKPFGS VSVESKMNNK AGSFFWNLRQ FSTLVSTSRT MRLCCLGLCK PKIVHSNWNI 
LNNFHNRMQS TDIIRYLFQD AFIFKSDVGF QTKGISTLTA LRIERLLYAK RLFFDSKQSL 
VPVDKSDDEL KKVNLNHEVS NEDVLTKETK PNRISSRKLS EECNSLSDVL DAFSKAPTFP 
SSNYFTAMWT IAKRLSDDQK RFEKRLMFSH PAFNQLCEHM MREAKIMQYK YLLFSLHAIV 
KLGIPQNTIL VQTLLRVTQE RINECDEICL SVLSTVLEAM EPCKNVHVLR TGFRILVDQQ 
VWKIEDVFTL QVVMKCIGKD APIALKRKLE MKALRELDRF SVLNSQHMFE VLAAMNHRSL 
ILLDECSKVV LDNIHGCPLR IMINILQSCK DLQYHNLDLF KGLADYVAAT FDIWKFRKVL 
FILILFENLG FRPVGLMDLF MKRIVEDPES LNMKNILSIL HTYSSLNHVY KCQNKEQFVE 
VMASALTGYL HTISSENLLD AVYSFCLMNY FPLAPFNQLL QKDIISELLT SDDMKNAYKL 
HTLDTCLKLD DTVYLRDIAL SLPQLPRELP SSHTNAKVAE VLSSLLGGEG HFSKDVHLPH 
NYHIDFEIRM DTNRNQVLPL SDVDTTSATD IQRVAVLCVS RSAYCLGSSH PRGFLAMKMR 
HLNAMGFHVI LVNNWEMDKL EMEDAVTFLK TKIYSVEALP VAAVNVQSTQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FASTKD2

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10231032

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency. PubMed ID: 18771761

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. PubMed ID: 20869947

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mitochondrial RNA granules are centers for post-transcriptional RNA processing and ribosome biogenesis. PubMed ID: 25683715

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation. PubMed ID: 26370583

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. PubMed ID: 27667664

Identification of FASTKD2 compound heterozygous mutations as the underlying cause of autosomal recessive MELAS-like syndrome. PubMed ID: 28499982

Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. PubMed ID: 31944455