Details for: MLXIP

Gene ID: 22877

Symbol: MLXIP

Ensembl ID: ENSG00000175727

Description: MLX interacting protein

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.6
    Marker Score: 6,520
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.93
    Marker Score: 3,713
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.89
    Marker Score: 4,144
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.85
    Marker Score: 2,180
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.68
    Marker Score: 3,819
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.67
    Marker Score: 1,781
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.62
    Marker Score: 16,385
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.6
    Marker Score: 13,931
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.56
    Marker Score: 57,604
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.55
    Marker Score: 1,097
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23,078
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.53
    Marker Score: 3,229
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29,892
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91,444
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.47
    Marker Score: 817
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12,556
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.46
    Marker Score: 550
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.45
    Marker Score: 3,411
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.45
    Marker Score: 13,606
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.45
    Marker Score: 14,929
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13,734
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.41
    Marker Score: 4,432
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.4
    Marker Score: 1,691
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.39
    Marker Score: 15,681
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.38
    Marker Score: 1,526
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.34
    Marker Score: 342
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.32
    Marker Score: 2,502
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5,314
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.3
    Marker Score: 5,043
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.3
    Marker Score: 1,890
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.28
    Marker Score: 1,273
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.27
    Marker Score: 1,373
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48,057
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1,863
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.26
    Marker Score: 441
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.25
    Marker Score: 594
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.25
    Marker Score: 1,311
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1,432
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.24
    Marker Score: 21,946
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.23
    Marker Score: 636
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.22
    Marker Score: 41,615
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2,879
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.21
    Marker Score: 2,750
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.2
    Marker Score: 758
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.2
    Marker Score: 2,852
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.18
    Marker Score: 66,203
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.18
    Marker Score: 375
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.18
    Marker Score: 1,264
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.18
    Marker Score: 4,909
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 585
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.18
    Marker Score: 1,134
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.17
    Marker Score: 1,265
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1,805
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,214
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.17
    Marker Score: 431
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.16
    Marker Score: 15,314
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.14
    Marker Score: 393
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.14
    Marker Score: 776
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.13
    Marker Score: 3,896
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 526
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 651
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.12
    Marker Score: 451
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.12
    Marker Score: 2,921
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4,248
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.1
    Marker Score: 1,112
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.09
    Marker Score: 946
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.09
    Marker Score: 1,363
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.09
    Marker Score: 932
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.09
    Marker Score: 743
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.09
    Marker Score: 4,034
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.09
    Marker Score: 1,042
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2,939
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.08
    Marker Score: 338
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.08
    Marker Score: 1,084
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.07
    Marker Score: 1,502
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.07
    Marker Score: 1,375
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.06
    Marker Score: 4,393
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.06
    Marker Score: 1,235
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.06
    Marker Score: 384
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.05
    Marker Score: 8,084
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.05
    Marker Score: 337
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.05
    Marker Score: 728
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.04
    Marker Score: 540
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.04
    Marker Score: 992
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.03
    Marker Score: 646
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.03
    Marker Score: 1,832
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 389
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.01
    Marker Score: 6,465
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.01
    Marker Score: 413
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.01
    Marker Score: 16,191
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 924
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.01
    Marker Score: 488
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,602
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,825
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.99
    Marker Score: 490
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.99
    Marker Score: 358
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.98
    Marker Score: 9,877

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **RNA Polymerase II (RNAP II) interaction**: MLXIP interacts with RNAP II, a key enzyme responsible for transcribing protein-coding genes in eukaryotic cells. This interaction modulates the activity of RNAP II, influencing the transcriptional output of target genes. 2. **Transcriptional regulation**: MLXIP is involved in the regulation of transcription by RNAP II, modulating the expression of specific genes in response to various cellular signals. 3. **Protein dimerization**: The MLXIP protein can form dimers, which are essential for its function in regulating transcriptional activity. 4. **Cell-type specificity**: MLXIP is expressed in a range of cell types, including skeletal muscle fibers, kidney interstitial fibroblasts, and salivary gland acinar cells, suggesting a role in specific cellular processes. **Pathways and Functions** 1. **Chromatin remodeling**: MLXIP interacts with chromatin remodeling complexes, influencing the structure and organization of chromatin to regulate gene expression. 2. **Transcriptional activation**: MLXIP promotes the activation of transcription by RNAP II, leading to the expression of target genes involved in cellular processes such as differentiation, development, and cell survival. 3. **Cell cycle regulation**: MLXIP may play a role in regulating the cell cycle, particularly in the context of cell proliferation and differentiation. 4. **Neurotransmission and synaptic plasticity**: The MLXIP protein is expressed in neurons, suggesting a potential role in neurotransmission and synaptic plasticity. **Clinical Significance** 1. **Muscular dystrophy**: Mutations in the MLXIP gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cancer**: The MLXIP protein has been implicated in the regulation of gene expression in cancer cells, suggesting a potential role in tumorigenesis and cancer progression. 3. **Neurological disorders**: The MLXIP protein is expressed in neurons, and alterations in its expression or function may contribute to neurological disorders such as epilepsy, Alzheimer's disease, and Parkinson's disease. 4. **Gene therapy**: The MLXIP gene may serve as a target for gene therapy interventions aimed at treating muscular dystrophy and other genetic disorders. In conclusion, the MLXIP gene plays a critical role in regulating transcriptional activity in various cell types, influencing cellular processes such as differentiation, development, and cell survival. Further research is needed to fully elucidate the functions and clinical significance of the MLXIP protein in human disease.

Genular Protein ID: 1982868329

Symbol: MLXIP_HUMAN

Name: MLX-interacting protein

UniProtKB Accession Codes:

Q9HAP2 A7MBN0 O94945 Q7LC47 Q8IXP1 Q8TAH9 Q8WVQ0 Q8WYA5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11073985

Title: MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network.

PubMed ID: 11073985

DOI: 10.1128/mcb.20.23.8845-8854.2000

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12446771

Title: A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.

PubMed ID: 12446771

DOI: 10.1128/mcb.22.24.8514-8526.2002

PubMed ID: 16782875

Title: MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.

PubMed ID: 16782875

DOI: 10.1128/mcb.00657-05

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 919
  • Mass: 101185
  • Checksum: 47375FCC4333E0C2
  • Sequence:
    • MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP 
PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL 
SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN 
PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED 
LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP 
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN 
PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP 
PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA 
PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH 
PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML 
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG 
EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR 
QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA 
RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII 
IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ 
LPEQASKAVT RIGKRLGES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.