Details for: TRAPPC8

Gene ID: 22878

Symbol: TRAPPC8

Ensembl ID: ENSG00000153339

Description: trafficking protein particle complex subunit 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.78
    Marker Score: 3,915
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.74
    Marker Score: 66,130
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.73
    Marker Score: 63,928
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.72
    Marker Score: 105,733
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.7
    Marker Score: 25,482
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.7
    Marker Score: 33,825
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6,830
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.65
    Marker Score: 1,828
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.65
    Marker Score: 1,903
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.64
    Marker Score: 12,603
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.64
    Marker Score: 15,621
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.64
    Marker Score: 35,008
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15,398
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.62
    Marker Score: 6,263
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13,864
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6,484
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.56
    Marker Score: 457
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.48
    Marker Score: 15,247
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.45
    Marker Score: 6,076
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2,240
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.36
    Marker Score: 1,830
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.32
    Marker Score: 791
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.29
    Marker Score: 540
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.27
    Marker Score: 633
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.27
    Marker Score: 628
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.24
    Marker Score: 1,777
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.23
    Marker Score: 649
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.23
    Marker Score: 1,490
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.23
    Marker Score: 945
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.22
    Marker Score: 2,341
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.19
    Marker Score: 7,664
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.18
    Marker Score: 688
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.16
    Marker Score: 677
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.15
    Marker Score: 38,990
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.14
    Marker Score: 1,224
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.12
    Marker Score: 4,827
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.11
    Marker Score: 3,806
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17,083
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.09
    Marker Score: 742
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.09
    Marker Score: 297
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.07
    Marker Score: 4,970
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.04
    Marker Score: 1,295
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.03
    Marker Score: 578
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.02
    Marker Score: 377
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.02
    Marker Score: 5,465
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1
    Marker Score: 2,389
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,920
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.99
    Marker Score: 3,525
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.97
    Marker Score: 309
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.97
    Marker Score: 21,689
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.97
    Marker Score: 361
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.96
    Marker Score: 920
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.96
    Marker Score: 577
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2,255
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.95
    Marker Score: 1,015
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.95
    Marker Score: 299
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.93
    Marker Score: 1,166
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.92
    Marker Score: 446
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.92
    Marker Score: 312
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.91
    Marker Score: 1,128
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1,839
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,705
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.9
    Marker Score: 780
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.89
    Marker Score: 257
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,446
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.88
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.86
    Marker Score: 2,464
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1,222
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.86
    Marker Score: 599
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.86
    Marker Score: 868
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,844
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.84
    Marker Score: 14,988
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.84
    Marker Score: 634
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.84
    Marker Score: 241
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.82
    Marker Score: 7,131
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 710
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.82
    Marker Score: 547
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 977
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.81
    Marker Score: 916
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 446
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 256
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.79
    Marker Score: 12,746
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.79
    Marker Score: 1,332
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 833
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.79
    Marker Score: 208
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.79
    Marker Score: 297
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.78
    Marker Score: 283
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.78
    Marker Score: 316
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.77
    Marker Score: 3,225
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2,060

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of TRAPP Complex**: TRAPPC8 is a constituent of the TRAPP complex, a hetero-oligomeric protein complex that mediates vesicle-mediated transport between the endoplasmic reticulum (ER) and the Golgi apparatus. 2. **Regulation of Membrane Trafficking**: TRAPPC8 is involved in the regulation of membrane trafficking, a process critical for maintaining cellular homeostasis, cellular differentiation, and synaptic plasticity. 3. **Expression in Neuronal and Epithelial Cells**: TRAPPC8 is significantly expressed in various cell types, including neurons, ciliary muscle cells, and corneal epithelial cells, highlighting its importance in maintaining cellular function and integrity. 4. **Involvement in Multiple Pathways**: TRAPPC8 is implicated in multiple cellular pathways, including copii vesicle coating, cytoplasmic transport, and vesicle tethering, underscoring its multifaceted role in cellular trafficking. **Pathways and Functions:** TRAPPC8 is involved in the following pathways and functions: 1. **Copii Vesicle Coating**: TRAPPC8 regulates the coating of copii vesicles, which are involved in the transport of proteins and lipids between the ER and the Golgi apparatus. 2. **Cytoplasmic Transport**: TRAPPC8 facilitates the transport of vesicles through the cytoplasm, enabling the movement of molecules between the ER and the Golgi apparatus. 3. **Vesicle Tethering**: TRAPPC8 regulates the tethering of vesicles to the ER and the Golgi apparatus, ensuring the proper delivery of molecules to their target destinations. 4. **Rab GTPase Regulation**: TRAPPC8 interacts with Rab GTPases, which regulate the cycling of vesicles between the ER and the Golgi apparatus. 5. **Protein Binding**: TRAPPC8 interacts with various proteins, including Rab GTPases, to regulate membrane trafficking and cellular function. **Clinical Significance:** Dysregulation of TRAPPC8 has been implicated in various neurodegenerative and developmental disorders, including: 1. **Neurodevelopmental Disorders**: TRAPPC8 is involved in the regulation of synaptic plasticity and neuronal development, highlighting its importance in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Disorders**: TRAPPC8 is implicated in the regulation of membrane trafficking and cellular homeostasis, underscoring its potential role in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: TRAPPC8 is involved in the regulation of membrane trafficking and cellular homeostasis, highlighting its potential role in cancer development and progression. In conclusion, TRAPPC8 is a critical component of the TRAPP complex, playing a pivotal role in regulating membrane trafficking and cellular homeostasis. Its significant expression in various cell types and involvement in multiple pathways highlight its importance in maintaining cellular function and integrity. Further research is necessary to elucidate the mechanisms by which TRAPPC8 regulates membrane trafficking and its potential role in various diseases.

Genular Protein ID: 3050139758

Symbol: TPPC8_HUMAN

Name: Trafficking protein particle complex subunit 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11805826

Title: Functional organization of the yeast proteome by systematic analysis of protein complexes.

PubMed ID: 11805826

DOI: 10.1038/415141a

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26711178

Title: TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.

PubMed ID: 26711178

DOI: 10.15252/embj.201592695

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1435
  • Mass: 160997
  • Checksum: A6D60A7C9E65F46D
  • Sequence:
  • MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT SEVHMRDPNN 
    QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE GLVANVITAG DYDLNISATT 
    PWFESYRETF LQSMPALDHE FLNHYLACML VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS 
    YPKWFIPNTL KYYVLLHDVS AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ 
    IPDPWSQYLQ KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL 
    QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ FIQEFTFRGL 
    LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE KSINDLKNTS GLLYPPEAPE 
    LQIRKMADLC FLVQHYDLAY SCYHTAKKDF LNDQAMLYAA GALEMAAVSA FLQPGAPRPY 
    PAHYMDTAIQ TYRDICKNMV LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL 
    LLEQAAHCFI NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE 
    DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY KNVSQLSPDG 
    PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ EYDSESSQQW RELEEQVVSV 
    VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV VEEPITVEVA FRNPLKVLLL LTDLSLLWKF 
    HPKDFSGKDN EEVKQLVTSE PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV 
    YNLGTIQGSM TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD 
    RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV VSKRPEFFTF 
    GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS SVDFGIGTGS QPEVIPVPLP 
    DTVLLPGASV QLPMWLRGPD EEGVHEINFL FYYESVKKQP KIRHRILRHT AIICTSRSLN 
    VRATVCRSNS LENEEGRGGN MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL 
    SENKDTKLAS REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY 
    RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE DSKQLILEGQ 
    HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR PSVEQLSSLI KTSLHYPESF 
    NHPFHQKSLC LVPVTLLLSN CSKADVDVIV DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL 
    KSQEIHSLQL KACFVHTGVY NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.