Details for: MON1B

Gene ID: 22879

Symbol: MON1B

Ensembl ID: ENSG00000103111

Description: MON1 homolog B, secretory trafficking associated

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.07
    Marker Score: 716
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1,986
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,721
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,946
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,262
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,701
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,241
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.85
    Marker Score: 1,937
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.85
    Marker Score: 1,252
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,835
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.84
    Marker Score: 572
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.74
    Marker Score: 222
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.74
    Marker Score: 214
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,471
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.71
    Marker Score: 747
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 424
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7
    Marker Score: 1,230
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.7
    Marker Score: 1,658
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7
    Marker Score: 1,400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.7
    Marker Score: 327
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,903
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 166
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4,116
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 219
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5,810
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.67
    Marker Score: 697
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.67
    Marker Score: 1,413
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.67
    Marker Score: 4,270
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1,644
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.66
    Marker Score: 36,769
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.63
    Marker Score: 4,131
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.62
    Marker Score: 15,960
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.62
    Marker Score: 307
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.61
    Marker Score: 427
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6,238
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6
    Marker Score: 258
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 395
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.59
    Marker Score: 6,914
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.58
    Marker Score: 413
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.58
    Marker Score: 2,010
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.58
    Marker Score: 592
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.58
    Marker Score: 143
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 181
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.57
    Marker Score: 572
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.57
    Marker Score: 4,254
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.57
    Marker Score: 131
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.57
    Marker Score: 331
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.56
    Marker Score: 5,356
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.56
    Marker Score: 601
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.56
    Marker Score: 539
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.56
    Marker Score: 3,417
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.56
    Marker Score: 8,382
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.55
    Marker Score: 854
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.55
    Marker Score: 33,813
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.55
    Marker Score: 2,630
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.55
    Marker Score: 1,067
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.55
    Marker Score: 310
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.54
    Marker Score: 329
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.53
    Marker Score: 5,421
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.53
    Marker Score: 1,666
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.52
    Marker Score: 1,403
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.52
    Marker Score: 4,543
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.52
    Marker Score: 106
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.52
    Marker Score: 465
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.52
    Marker Score: 378
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.52
    Marker Score: 913
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.51
    Marker Score: 3,925
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.51
    Marker Score: 512
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.51
    Marker Score: 253
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.51
    Marker Score: 346
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5
    Marker Score: 19,065
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.5
    Marker Score: 113
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.5
    Marker Score: 312
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.5
    Marker Score: 1,348
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.49
    Marker Score: 256
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.49
    Marker Score: 112
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.49
    Marker Score: 654
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.49
    Marker Score: 169
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.49
    Marker Score: 1,108
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.49
    Marker Score: 1,446
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.49
    Marker Score: 748
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.49
    Marker Score: 120
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.49
    Marker Score: 223
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.48
    Marker Score: 116
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.48
    Marker Score: 1,219

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MON1B is a member of the MON1 family, which consists of four homologs, including MON1A, MON1B, MON1C, and MON1D. These proteins share a high degree of sequence homology and are involved in various cellular processes, including membrane trafficking, protein targeting to vacuoles, and vesicle-mediated transport. MON1B is specifically expressed in cells involved in immune responses, such as goblet cells in the nasal mucosa, cardiac endothelial cells, and GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** MON1B is involved in several cellular pathways, including: 1. **Membrane Trafficking:** MON1B regulates the trafficking of proteins and lipids between the endoplasmic reticulum and the Golgi apparatus, ensuring proper sorting and targeting of proteins to their respective destinations. 2. **Protein Targeting to Vacuoles:** MON1B facilitates the targeting of proteins to vacuoles, which are essential for protein degradation, autophagy, and immune responses. 3. **Vesicle-Mediated Transport:** MON1B regulates the formation and movement of vesicles, which are involved in the transport of proteins and lipids between cells and between different cellular compartments. 4. **Rab GEF Activity:** MON1B acts as a Rab GEF (GTPase-activating protein), converting Rab GTPases into their active forms, which are essential for regulating membrane trafficking and vesicle-mediated transport. **Clinical Significance:** MON1B has been implicated in various diseases, including: 1. **Immune-Related Disorders:** MON1B is expressed in cells involved in immune responses, making it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders:** MON1B is expressed in GABAergic interneurons, which are involved in regulating neuronal activity. Abnormalities in MON1B expression have been linked to neurological disorders, such as epilepsy and schizophrenia. 3. **Cancer:** MON1B has been implicated in cancer development and progression, particularly in the context of immune evasion and tumor metastasis. In conclusion, MON1B is a critical gene involved in regulating membrane trafficking, protein targeting to vacuoles, and vesicle-mediated transport. Its dysregulation has been linked to various diseases, including immune-related disorders, neurological disorders, and cancer. Further research is needed to fully understand the function and significance of MON1B and its potential therapeutic applications. **References:** * [Insert relevant literature and references] Note: The references provided should be based on the actual literature and should be included in the article. The references mentioned in this example are fictional and should not be used as actual references.

Genular Protein ID: 2399974636

Symbol: MON1B_HUMAN

Name: Vacuolar fusion protein MON1 homolog B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12828340

Title: Identification of a novel human MON1/SAND family protein in human fibroblasts induced by herpes simplex virus 1 binding.

PubMed ID: 12828340

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21509660

Title: HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2.

PubMed ID: 21509660

DOI: 10.1007/s11427-011-4160-3

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29038162

Title: Systematic analysis of human cells lacking ATG8 proteins uncovers roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macro and selective autophagic flux.

PubMed ID: 29038162

DOI: 10.1128/mcb.00392-17

Sequence Information:

  • Length: 547
  • Mass: 59217
  • Checksum: 06ED0B7C42AA2D17
  • Sequence:
  • MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETG SKDKDQPPSP 
    SPPPQSEALS STSRLWSPAA PENSPTCSPE SSSGGQGGDP SDEEWRSQRK HVFVLSEAGK 
    PIYSRYGSVE ALSATMGVMT ALVSFVQSAG DAIRAIYAED HKLVFLQQGP LLLVAMSRTS 
    QSAAQLRGEL LAVHAQIVST LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP 
    GALLLGAVRC VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD 
    PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL LLLGTQREAF 
    HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY SVQAVGAPGL RHFLYKPLDI 
    PDHHRQLPQF TSPELEAPYS REEERQRLSD LYHRLHARLH STSRPLRLIY HVAEKETLLA 
    WVTSKFELYT CLSPLVTKAG AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH 
    NGLFTGL

Genular Protein ID: 214912901

Symbol: Q6ZR87_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 427
  • Mass: 47369
  • Checksum: AE7E66632ED3AAAB
  • Sequence:
  • MWTRAWCVYG RRGQKSPTVS LWSFLIQLYP PFLPLPSLED HKLVFLQQGP LLLVAMSRTS 
    QSAAQLRGEL LAVHAQIVST LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP 
    GALLLGAVRC VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD 
    PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL LLLGTQREAF 
    HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY SVQAVGAPGL RHFLYKPLDI 
    PDHHRQLPQF TSPELEAPYS REEERQRLSD LYHRLHARLH STSRPLRLIY HVAEKETLLA 
    WVTSKFELYT CLSPLVTKAG AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH 
    NGLFTGL

Genular Protein ID: 3427633789

Symbol: E7EW32_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 438
  • Mass: 47837
  • Checksum: BAB2FE68A2AC6859
  • Sequence:
  • MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETE DHKLVFLQQG 
    PLLLVAMSRT SQSAAQLRGE LLAVHAQIVS TLTRASVARI FAHKQNYDLR RLLAGSERTL 
    DRLLDSMEQD PGALLLGAVR CVPLARPLRD ALGALLRRCT APGLALSVLA VGGRLITAAQ 
    ERNVLAECRL DPADLQLLLD WVGAPAFAAG EAWAPVCLPR FNPDGFFYAY VARLDAMPVC 
    LLLLGTQREA FHAMAACRRL VEDGMHALGA MRALGEAASF SNASSASAPA YSVQAVGAPG 
    LRHFLYKPLD IPDHHRQLPQ FTSPELEAPY SREEERQRLS DLYHRLHARL HSTSRPLRLI 
    YHVAEKETLL AWVTSKFELY TCLSPLVTKA GAILVVTKLL RWVKKEEDRL FIRYPPKYST 
    PPATSTDQAA HNGLFTGL

Genular Protein ID: 3248249513

Symbol: B4DKA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 438
  • Mass: 47805
  • Checksum: 1AB2FB71BEAC6103
  • Sequence:
  • MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETE DHKLVFLQQG 
    PLLLVAMSRT SQSAAQLRGE LLAVHAQIVS TLTRASVARI FAHKQNYDLR RLLAGSERTL 
    DRLLDSMEQD PGALPLGAVR CVPLARPLRD ALGALLRRCT APGLALSVLA VGGRLITAAQ 
    ERNVLAECRL DPADLQLLLD WVGAPAFAAG EAWAPVCLPR FNPDGFFYAY VARLDAMPVC 
    LLLLGTQREA FHAMAACRRL VEDGMHALGA MRALGEAASF SNASSASAPA YSVQAVGAPG 
    LRHFLYKPLD IPDHHRQLPQ FTSPELEAPY SREEERQRLS DLYHRLHARL HSTSRPLRLI 
    YHVAEKETLL AWVTSKFELY TCLSPLVTKA GAILVVTKLL RWVKKEEDRL FIRYPPKYST 
    PPATSTDQAA HNGLFTGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.