MORC2 | ENSG00000133422 | NCBI 22880

Details for: MORC2

Gene ID: 22880

Symbol: MORC2

Ensembl ID: ENSG00000133422

Description: MORC family CW-type zinc finger 2

Associated with

Fatty acid metabolism
(R-HSA-8978868)
Fatty acyl-coa biosynthesis
(R-HSA-75105)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Fatty acid metabolic process
(GO:0006631)
Heterochromatin
(GO:0000792)
Magnesium ion binding
(GO:0000287)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045869)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna methylation-dependent heterochromatin formation
(GO:0090309)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Zinc finger CW-type coiled-coil domain protein 1

Genular Protein ID: 2616788780

Symbol: MORC2_HUMAN

Name: Zinc finger CW-type coiled-coil domain protein 1

UniProtKB Accession Codes:

Q9Y6X9 B2RNB1 Q9UF28 Q9Y6V2

Database IDs:

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20225202

Title: Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells.

PubMed ID: 20225202

DOI: 10.1002/ar.21119

PubMed ID: 20110259

Title: Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX.

PubMed ID: 20110259

DOI: 10.1093/nar/gkq006

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23260667

Title: MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.

PubMed ID: 23260667

DOI: 10.1016/j.celrep.2012.11.018

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24286864

Title: Cytosolic functions of MORC2 in lipogenesis and adipogenesis.

PubMed ID: 24286864

DOI: 10.1016/j.bbamcr.2013.11.012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29211708

Title: Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.

PubMed ID: 29211708

DOI: 10.1038/nature25179

PubMed ID: 26659848

Title: MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs.

PubMed ID: 26659848

DOI: 10.1002/ana.24575

PubMed ID: 26497905

Title: Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.

PubMed ID: 26497905

DOI: 10.1093/brain/awv311

PubMed ID: 27329773

Title: MORC2 mutations in a cohort of Chinese patients with Charcot-Marie-Tooth disease type 2.

PubMed ID: 27329773

DOI: 10.1093/brain/aww156

PubMed ID: 27794525

Title: MORC2 mutation causes severe spinal muscular atrophy-phenotype, cerebellar atrophy, and diaphragmatic paralysis.

PubMed ID: 27794525

DOI: 10.1093/brain/aww252

PubMed ID: 28402445

Title: De novo p.T362R mutation in MORC2 causes early onset cerebellar ataxia, axonal polyneuropathy and nocturnal hypoventilation.

PubMed ID: 28402445

DOI: 10.1093/brain/awx083

PubMed ID: 28771897

Title: Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in Japan.

PubMed ID: 28771897

DOI: 10.1111/ene.13360

PubMed ID: 28581500

Title: Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

PubMed ID: 28581500

DOI: 10.1038/ng.3878

PubMed ID: 32693025

Title: De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism.

PubMed ID: 32693025

DOI: 10.1016/j.ajhg.2020.06.013

PubMed ID: 29440755

Title: Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

PubMed ID: 29440755

DOI: 10.1038/s41467-018-03045-x

Sequence Information:

Length: 1032
Mass: 117823
Checksum: 7BEFA46E4150ABF5
Sequence:

MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG 
GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK 
KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFRT 
EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF 
RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR 
IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNRAI TLRREADVKK RIKEAKQRAL 
KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV 
LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS 
SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE 
QKQKVPLGTF RKDMKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR 
PSTEEPVRRP QRPRSPPLPA VIRNAPSRPP SLPTPRPASQ PRKAPVISST PKLPALAARE 
EASTSRLLQP PEAPRKPANT LVKTASRPAP LVQQLSPSLL PNSKSPREVP SPKVIKTPVV 
KKTESPIKLS PATPSRKRSV AVSDEEEVEE EAERRKERCK RGRFVVKEEK KDSNELSDSA 
GEEDSADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR 
WVEKGSEDVR LMKPPSPEHQ SLDTQQEGGE EEVGPVAQQA IAVAEPSTSE CLRIEPDTTA 
LSTNHETIDL LVQILRNCLR YFLPPSFPIS KKQLSAMNSD ELISFPLKEY FKQYEVGLQN 
LCNSYQSRAD SRAKASEESL RTSERKLRET EEKLQKLRTN IVALLQKVQE DIDINTDDEL 
DAYIEDLITK GD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MORC2

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells. PubMed ID: 20225202

Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX. PubMed ID: 20110259

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. PubMed ID: 23260667

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Cytosolic functions of MORC2 in lipogenesis and adipogenesis. PubMed ID: 24286864

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. PubMed ID: 29211708

MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs. PubMed ID: 26659848

Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease. PubMed ID: 26497905

MORC2 mutations in a cohort of Chinese patients with Charcot-Marie-Tooth disease type 2. PubMed ID: 27329773

MORC2 mutation causes severe spinal muscular atrophy-phenotype, cerebellar atrophy, and diaphragmatic paralysis. PubMed ID: 27794525

De novo p.T362R mutation in MORC2 causes early onset cerebellar ataxia, axonal polyneuropathy and nocturnal hypoventilation. PubMed ID: 28402445

Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in Japan. PubMed ID: 28771897

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. PubMed ID: 28581500

De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism. PubMed ID: 32693025

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. PubMed ID: 29440755