Details for: ANKRD6

Gene ID: 22881

Symbol: ANKRD6

Ensembl ID: ENSG00000135299

Description: ankyrin repeat domain 6

Associated with

  • Cytoplasm
    (GO:0005737)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Nucleus
    (GO:0005634)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of wnt signaling pathway, planar cell polarity pathway
    (GO:2000096)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.83
    Marker Score: 11,840
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.4
    Marker Score: 18,392
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.26
    Marker Score: 33,810
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.95
    Marker Score: 73,875
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.82
    Marker Score: 619
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.81
    Marker Score: 1,057
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.75
    Marker Score: 6,783
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,062
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.74
    Marker Score: 16,488
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.71
    Marker Score: 16,046
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.64
    Marker Score: 519
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6
    Marker Score: 16,517
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.6
    Marker Score: 6,505
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,159
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29,850
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,859
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.4
    Marker Score: 29,793
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.37
    Marker Score: 5,696
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.32
    Marker Score: 1,017
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.31
    Marker Score: 80,731
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.3
    Marker Score: 379
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.27
    Marker Score: 42,912
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.22
    Marker Score: 1,054
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.19
    Marker Score: 1,349
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.15
    Marker Score: 2,204
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,796
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.13
    Marker Score: 1,003
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17,576
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.07
    Marker Score: 4,968
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.06
    Marker Score: 595
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.06
    Marker Score: 482
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.03
    Marker Score: 375
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.03
    Marker Score: 2,263
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2,376
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,022
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.99
    Marker Score: 1,142
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 663
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.95
    Marker Score: 1,179
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.91
    Marker Score: 1,100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,156
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9
    Marker Score: 14,437
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.9
    Marker Score: 464
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.89
    Marker Score: 344
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.89
    Marker Score: 5,293
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.87
    Marker Score: 752
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.86
    Marker Score: 821
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 945
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.81
    Marker Score: 468
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,636
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.8
    Marker Score: 2,837
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,734
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 325
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 461
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.76
    Marker Score: 28,094
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.76
    Marker Score: 820
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.76
    Marker Score: 379
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.76
    Marker Score: 3,965
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.73
    Marker Score: 16,351
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.73
    Marker Score: 478
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.72
    Marker Score: 1,183
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.72
    Marker Score: 1,650
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7
    Marker Score: 1,223
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.7
    Marker Score: 417
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.69
    Marker Score: 3,718
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 214
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.68
    Marker Score: 474
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.68
    Marker Score: 675
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.68
    Marker Score: 137
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.66
    Marker Score: 699
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.65
    Marker Score: 997
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 202
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.62
    Marker Score: 2,566
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 870
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.61
    Marker Score: 750
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.59
    Marker Score: 188
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.59
    Marker Score: 1,921
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.58
    Marker Score: 774
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 676
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.55
    Marker Score: 4,130
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.55
    Marker Score: 931
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 561

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ankyrin repeat domains**: The ANKRD6 protein contains multiple ankyrin repeat domains, which are responsible for its interactions with other proteins and modulate its functions. 2. **Wnt signaling pathway regulation**: ANKRD6 has been shown to positively regulate the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 3. **JNK cascade regulation**: ANKRD6 also positively regulates the JNK cascade, a signaling pathway involved in cellular stress response, apoptosis, and differentiation. 4. **Negative regulation of canonical Wnt signaling**: In contrast to its positive regulation of the Wnt signaling pathway, ANKRD6 has also been shown to negatively regulate the canonical Wnt signaling pathway, which is involved in cell proliferation and differentiation. **Pathways and Functions** ANKRD6 has been implicated in various cellular processes, including: 1. **Negative regulation of canonical Wnt signaling pathway**: ANKRD6 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation and differentiation. 2. **Positive regulation of JNK cascade**: ANKRD6 positively regulates the JNK cascade, a signaling pathway involved in cellular stress response, apoptosis, and differentiation. 3. **Positive regulation of Wnt signaling pathway**: ANKRD6 positively regulates the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 4. **Planar cell polarity pathway regulation**: ANKRD6 has been implicated in the regulation of the planar cell polarity pathway, which is involved in cellular polarity and orientation. **Clinical Significance** ANKRD6 has been associated with various diseases and disorders, including: 1. **Neurological disorders**: ANKRD6 has been implicated in the regulation of GABAergic cortical interneurons, which are involved in neurological disorders, such as epilepsy and schizophrenia. 2. **Cancer**: ANKRD6 has been shown to be overexpressed in various types of cancer, including breast cancer and colon cancer, suggesting its potential role in tumorigenesis. 3. **Eye disorders**: ANKRD6 has been implicated in the regulation of lens fibers, which are involved in eye disorders, such as cataracts and glaucoma. In conclusion, ANKRD6 is a complex gene that plays a multifaceted role in various cellular processes, including the regulation of Wnt and JNK signaling pathways, planar cell polarity, and cellular polarity. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target for the treatment of these conditions. Further research is needed to fully elucidate the functions of ANKRD6 and its implications in human disease.

Genular Protein ID: 337927054

Symbol: ANKR6_HUMAN

Name: Ankyrin repeat domain-containing protein 6

UniProtKB Accession Codes:

Q9Y2G4 B3KUC3 Q5JUJ4 Q5JUJ5 Q8IUQ8 Q9NU24 Q9UFQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 727
  • Mass: 79971
  • Checksum: FACD861BDEEF1905
  • Sequence:
    • MSQQDAVAAL SERLLVAAYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI 
LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF 
SQSAKLLIKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV 
AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG 
QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG 
SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG 
HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK 
LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRL 
QQHSDTEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD 
QLVVTAGPAA ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM 
NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQPAASS TCGQPPPATG SEQTGPHIRD 
TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ DKATLKEHIK SLEEELAKLR 
TRVQKEN

Genular Protein ID: 3775006512

Symbol: B7Z3D2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3D2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 4 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 727
  • Mass: 79999
  • Checksum: 42873FE2F3F59D42
  • Sequence:
    • MSQQDAVAAL SERLLVAVYK GQTENVVQLI NKGARVAVTK HGRTPLHLAA NKGHLPVVQI 
LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF 
SQSAKLLIKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV 
AARYNHLSII RLLLTAFCSV HEKNQAGDTA LHVAAALNHK KVAKILLEAG ADTTIVNNAG 
QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG 
SVSAGDTPSS EQAVARKEEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG 
HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK 
LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRP 
QQHSDTEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD 
QLVVTAGPAA ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM 
NEAARSDQQA GPCVNRGTQT KKSGKSGPTR HRAQQLAASS TCGQPPPATG SEQTGPHIRD 
TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ DKATLKEHIK SLEEELAKLR 
TRVQKEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.