Details for: ZHX2

Gene ID: 22882

Symbol: ZHX2

Ensembl ID: ENSG00000178764

Description: zinc fingers and homeoboxes 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.29
    Marker Score: 73,543
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.27
    Marker Score: 4,404
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.96
    Marker Score: 7,406
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.92
    Marker Score: 3,539
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.92
    Marker Score: 12,225
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.92
    Marker Score: 62,330
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.87
    Marker Score: 9,417
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.71
    Marker Score: 1,506
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.44
    Marker Score: 1,604
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.42
    Marker Score: 43,028
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.39
    Marker Score: 2,756
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.37
    Marker Score: 692
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.35
    Marker Score: 4,519
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.12
    Marker Score: 722
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.12
    Marker Score: 1,635
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.1
    Marker Score: 1,229
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.08
    Marker Score: 4,566
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.03
    Marker Score: 1,338
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.99
    Marker Score: 4,774
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.88
    Marker Score: 1,050
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.81
    Marker Score: 2,250
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.77
    Marker Score: 1,537
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.77
    Marker Score: 2,189
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.77
    Marker Score: 1,952
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.76
    Marker Score: 6,274
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.71
    Marker Score: 846
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.67
    Marker Score: 481
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.65
    Marker Score: 1,149
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.65
    Marker Score: 985
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.65
    Marker Score: 1,864
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.64
    Marker Score: 866
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.54
    Marker Score: 896
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.52
    Marker Score: 24,386
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.49
    Marker Score: 4,261
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.49
    Marker Score: 386
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,456
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.47
    Marker Score: 1,581
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.47
    Marker Score: 532
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,864
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.46
    Marker Score: 1,263
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.44
    Marker Score: 1,374
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.44
    Marker Score: 454
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.38
    Marker Score: 804
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.37
    Marker Score: 8,791
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.36
    Marker Score: 1,025
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.36
    Marker Score: 10,413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21,154
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.32
    Marker Score: 740
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.31
    Marker Score: 1,161
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.27
    Marker Score: 690
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.25
    Marker Score: 5,071
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.24
    Marker Score: 5,368
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.24
    Marker Score: 6,642
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.23
    Marker Score: 46,595
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.2
    Marker Score: 454
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 720
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.18
    Marker Score: 39,748
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.15
    Marker Score: 1,939
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.11
    Marker Score: 293
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.11
    Marker Score: 3,944
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.09
    Marker Score: 1,538
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.07
    Marker Score: 1,553
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2,152
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.04
    Marker Score: 390
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6,243
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.01
    Marker Score: 257
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,955
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 667
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 308
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,036
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.95
    Marker Score: 14,259
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.95
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.95
    Marker Score: 8,122
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.94
    Marker Score: 665
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.93
    Marker Score: 293
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.92
    Marker Score: 3,575
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.92
    Marker Score: 1,116
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.91
    Marker Score: 1,090
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.91
    Marker Score: 440
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.88
    Marker Score: 325
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.88
    Marker Score: 355
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.87
    Marker Score: 917
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,933
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.86
    Marker Score: 272
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.86
    Marker Score: 920
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.85
    Marker Score: 312
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.85
    Marker Score: 405
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.83
    Marker Score: 2,247
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.81
    Marker Score: 245
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1,306

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZHX2 functions as a transcriptional regulator by binding to specific DNA sequences, thereby influencing the expression of target genes. Its ability to interact with RNA polymerase II is crucial for the regulation of transcriptional processes. 2. **Zinc Finger Domain:** The ZHX2 protein contains a zinc finger domain, a conserved structural motif found in many transcription factors. This domain is essential for DNA binding, allowing the protein to recognize and interact with specific DNA sequences. 3. **Homeobox Domain:** The homeobox domain present in ZHX2 is involved in the regulation of gene expression during development and differentiation. This domain can interact with other transcription factors, influencing the expression of target genes. 4. **Cell-Specific Expression:** ZHX2 is expressed in multiple cell types, including cardiac myocytes, lens cells, skeletal muscle fibers, and astrocytes. This cell-specific expression suggests that ZHX2 plays a critical role in maintaining tissue homeostasis. **Pathways and Functions:** 1. **Chromatin Remodeling:** ZHX2 interacts with chromatin remodeling complexes, influencing the structure and organization of chromatin. This interaction is essential for the regulation of gene expression. 2. **RNA Polymerase II Regulation:** ZHX2 binds to RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. This interaction regulates the transcriptional process, influencing the expression of target genes. 3. **Transcriptional Co-Regulation:** ZHX2 interacts with other transcription factors, influencing the expression of target genes. This co-regulation is essential for maintaining tissue homeostasis. 4. **Cell Differentiation:** ZHX2 plays a critical role in regulating cell differentiation, particularly in the development of retinal bipolar neurons and somatic stem cells. **Clinical Significance:** Dysregulation of ZHX2 has been implicated in various diseases, including: 1. **Cardiac Arrhythmias:** Abnormal expression of ZHX2 has been linked to cardiac arrhythmias, highlighting the importance of this gene in maintaining cardiac homeostasis. 2. **Neurological Disorders:** ZHX2 has been implicated in the regulation of neuronal differentiation and development, suggesting its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** Dysregulation of ZHX2 has been observed in various cancers, including breast cancer and lung cancer, highlighting the potential of this gene as a therapeutic target. In conclusion, ZHX2 is a critical gene that regulates various cellular processes, including transcriptional regulation, cell differentiation, and maintenance of stem cell populations. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ZHX2 and its potential therapeutic applications.

Genular Protein ID: 843008338

Symbol: ZHX2_HUMAN

Name: Zinc fingers and homeoboxes protein 2

UniProtKB Accession Codes:

Q9Y6X8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12741956

Title: Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.

PubMed ID: 12741956

DOI: 10.1042/bj20030171

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14659886

Title: The mouse zinc-fingers and homeoboxes (ZHX) family: ZHX2 forms a heterodimer with ZHX3.

PubMed ID: 14659886

DOI: 10.1016/j.gene.2003.09.013

PubMed ID: 17056598

Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.

PubMed ID: 17056598

DOI: 10.1074/jbc.m606664200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20509910

Title: Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.

PubMed ID: 20509910

DOI: 10.1186/1472-6807-10-13

Sequence Information:

  • Length: 837
  • Mass: 92307
  • Checksum: BE377ADF76D987D2
  • Sequence:
    • MASKRKSTTP CMVRTSQVVE QDVPEEVDRA KEKGIGTPQP DVAKDSWAAE LENSSKENEV 
IEVKSMGESQ SKKLQGGYEC KYCPYSTQNL NEFTEHVDMQ HPNVILNPLY VCAECNFTTK 
KYDSLSDHNS KFHPGEANFK LKLIKRNNQT VLEQSIETTN HVVSITTSGP GTGDSDSGIS 
VSKTPIMKPG KPKADAKKVP KKPEEITPEN HVEGTARLVT DTAEILSRLG GVELLQDTLG 
HVMPSVQLPP NINLVPKVPV PLNTTKYNSA LDTNATMINS FNKFPYPTQA ELSWLTAASK 
HPEEHIRIWF ATQRLKHGIS WSPEEVEEAR KKMFNGTIQS VPPTITVLPA QLAPTKVTQP 
ILQTALPCQI LGQTSLVLTQ VTSGSTTVSC SPITLAVAGV TNHGQKRPLV TPQAAPEPKR 
PHIAQVPEPP PKVANPPLTP ASDRKKTKEQ IAHLKASFLQ SQFPDDAEVY RLIEVTGLAR 
SEIKKWFSDH RYRCQRGIVH ITSESLAKDQ LAIAASRHGR TYHAYPDFAP QKFKEKTQGQ 
VKILEDSFLK SSFPTQAELD RLRVETKLSR REIDSWFSER RKLRDSMEQA VLDSMGSGKK 
GQDVGAPNGA LSRLDQLSGA QLTSSLPSPS PAIAKSQEQV HLLRSTFART QWPTPQEYDQ 
LAAKTGLVRT EIVRWFKENR CLLKTGTVKW MEQYQHQPMA DDHGYDAVAR KATKPMAESP 
KNGGDVVPQY YKDPKKLCEE DLEKLVTRVK VGSEPAKDCL PAKPSEATSD RSEGSSRDGQ 
GSDENEESSV VDYVEVTVGE EDAISDRSDS WSQAAAEGVS ELAESDSDCV PAEAGQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.