Details for: CLSTN1

Gene ID: 22883

Symbol: CLSTN1

Ensembl ID: ENSG00000171603

Description: calsyntenin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.23
    Marker Score: 14,922
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.61
    Marker Score: 19,455
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.49
    Marker Score: 49,454
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.39
    Marker Score: 35,753
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.36
    Marker Score: 9,873
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.34
    Marker Score: 1,220
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.28
    Marker Score: 4,627
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.25
    Marker Score: 85,398
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17,052
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.22
    Marker Score: 81,946
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9,059
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.07
    Marker Score: 2,785
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19,267
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.03
    Marker Score: 2,135
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7,832
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 123,984
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2
    Marker Score: 8,338
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2
    Marker Score: 1,502
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.95
    Marker Score: 1,978
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.92
    Marker Score: 2,121
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.91
    Marker Score: 40,752
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,845
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.88
    Marker Score: 2,127
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.88
    Marker Score: 5,032
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.87
    Marker Score: 7,245
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.86
    Marker Score: 10,009
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.86
    Marker Score: 19,239
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.86
    Marker Score: 588
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.85
    Marker Score: 9,704
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.84
    Marker Score: 15,946
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.83
    Marker Score: 535
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,672
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.82
    Marker Score: 1,283
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.8
    Marker Score: 6,180
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.79
    Marker Score: 1,199
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.78
    Marker Score: 2,302
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.78
    Marker Score: 2,046
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.76
    Marker Score: 2,131
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.76
    Marker Score: 2,953
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.73
    Marker Score: 1,139
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.71
    Marker Score: 6,332
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.67
    Marker Score: 1,572
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.66
    Marker Score: 1,757
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.64
    Marker Score: 962
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.6
    Marker Score: 12,100
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.6
    Marker Score: 6,502
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.59
    Marker Score: 3,661
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.59
    Marker Score: 667
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.57
    Marker Score: 1,698
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2,410
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.55
    Marker Score: 2,175
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.54
    Marker Score: 1,366
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.5
    Marker Score: 1,684
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.5
    Marker Score: 5,029
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.48
    Marker Score: 733
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.44
    Marker Score: 1,000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.44
    Marker Score: 1,780
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.43
    Marker Score: 4,091
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.43
    Marker Score: 3,613
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.43
    Marker Score: 4,494
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.43
    Marker Score: 426
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.42
    Marker Score: 663
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.41
    Marker Score: 2,679
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.41
    Marker Score: 1,701
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4
    Marker Score: 24,784
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.35
    Marker Score: 1,904
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.34
    Marker Score: 1,619
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.33
    Marker Score: 3,178
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.32
    Marker Score: 2,890
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.31
    Marker Score: 414
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.3
    Marker Score: 758
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.27
    Marker Score: 1,222
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.27
    Marker Score: 1,762
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.27
    Marker Score: 12,773
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.27
    Marker Score: 737
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.26
    Marker Score: 343
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.24
    Marker Score: 286
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.22
    Marker Score: 581
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.21
    Marker Score: 2,748
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13,492
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.18
    Marker Score: 428
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.18
    Marker Score: 703
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.17
    Marker Score: 372
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.17
    Marker Score: 1,117
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.16
    Marker Score: 651
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.16
    Marker Score: 1,200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.15
    Marker Score: 1,057
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.15
    Marker Score: 385
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.14
    Marker Score: 3,252
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.13
    Marker Score: 981
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 680
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.12
    Marker Score: 3,994
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.12
    Marker Score: 382
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.12
    Marker Score: 2,357
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.11
    Marker Score: 1,044
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.11
    Marker Score: 7,197
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.11
    Marker Score: 1,192
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.11
    Marker Score: 273
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.09
    Marker Score: 563

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLSTN1 is a transmembrane protein that belongs to the cadherin superfamily. It is characterized by its unique structure, which includes an extracellular domain that binds amyloid-beta peptides and a cytoplasmic domain that interacts with other proteins involved in synaptic function. CLSTN1 is highly expressed in the brain, particularly in inhibitory interneurons, which are crucial for regulating neuronal activity and maintaining synaptic homeostasis. **Pathways and Functions:** CLSTN1 is involved in several key pathways that regulate neuronal function and synaptic plasticity. These include: 1. **Amyloid-beta binding:** CLSTN1 binds to amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. This interaction is thought to regulate amyloid-beta-induced toxicity and promote synaptic dysfunction. 2. **Cell adhesion:** CLSTN1 interacts with other proteins involved in cell adhesion, such as cadherins and synapins, to regulate synaptic transmission and neuronal connectivity. 3. **Synaptic transmission:** CLSTN1 modulates synaptic transmission by regulating the activity of neurotransmitter receptors and ion channels, which are essential for neuronal communication. 4. **Synapse assembly:** CLSTN1 is involved in the regulation of synapse assembly and maturation, which is critical for the formation and maintenance of functional synapses. 5. **Vesicle-mediated transport:** CLSTN1 interacts with proteins involved in vesicle-mediated transport, which is essential for the regulation of neurotransmitter release and synaptic plasticity. **Clinical Significance:** CLSTN1 has been implicated in several neurological diseases, including Alzheimer's disease, frontotemporal dementia, and schizophrenia. Mutations in the CLSTN1 gene have been associated with these disorders, highlighting the protein's critical role in maintaining neuronal function and synaptic plasticity. Furthermore, CLSTN1 has been identified as a potential therapeutic target for the treatment of these diseases, particularly Alzheimer's disease, where it has been shown to modulate amyloid-beta-induced toxicity and promote synaptic function. In conclusion, Calsystenin 1 (CLSTN1) is a critical protein that regulates neuronal function and synaptic plasticity. Its involvement in various pathological processes, including Alzheimer's disease, highlights the need for further research into the molecular mechanisms underlying its function. Understanding the role of CLSTN1 in maintaining neuronal homeostasis and its potential as a therapeutic target will be essential for the development of novel treatments for neurological disorders.

Genular Protein ID: 2804733456

Symbol: CSTN1_HUMAN

Name: Alzheimer-related cadherin-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12972431

Title: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.

PubMed ID: 12972431

DOI: 10.1074/jbc.m306024200

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15037614

Title: Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.

PubMed ID: 15037614

DOI: 10.1074/jbc.m401925200

PubMed ID: 12498782

Title: The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns.

PubMed ID: 12498782

DOI: 10.1006/mcne.2002.1181

PubMed ID: 17332754

Title: The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.

PubMed ID: 17332754

DOI: 10.1038/sj.emboj.7601609

PubMed ID: 21385839

Title: Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

PubMed ID: 21385839

DOI: 10.1242/jcs.075168

Sequence Information:

  • Length: 981
  • Mass: 109793
  • Checksum: 01856284DEC3FC73
  • Sequence:
  • MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI 
    ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL 
    QKDYSFTIQA YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD 
    SILRVEAVDA DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY 
    DCGKKRATED VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ 
    ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD 
    QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL 
    YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE 
    PFSVTEDYPL HPSKIETQLV VGACWQEFSG VENDNETEPV TVASAGGDLH MTQFFRGNLA 
    GLTLRSGKLA DKKVIDCLYT CKEGLDLQVL EDSGRGVQIQ AHPSQLVLTL EGEDLGELDK 
    AMQHISYLNS RQFPTPGIRR LKITSTIKCF NEATCISVPP VDGYVMVLQP EEPKISLSGV 
    HHFARAASEF ESSEGVFLFP ELRIISTITR EVEPEGDGAE DPTVQESLVS EEIVHDLDTC 
    EVTVEGEELN HEQESLEVDM ARLQQKGIEV SSSELGMTFT GVDTMASYEE VLHLLRYRNW 
    HARSLLDRKF KLICSELNGR YISNEFKVEV NVIHTANPME HANHMAAQPQ FVHPEHRSFV 
    DLSGHNLANP HPFAVVPSTA TVVIVVCVSF LVFMIILGVF RIRAAHRRTM RDQDTGKENE 
    MDWDDSALTI TVNPMETYED QHSSEEEEEE EEEEESEDGE EEDDITSAES ESSEEEEGEQ 
    GDPQNATRQQ QLEWDDSTLS Y

Genular Protein ID: 1996245198

Symbol: B4E3Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 962
  • Mass: 107816
  • Checksum: 7BF0D0D723696E0F
  • Sequence:
  • MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI 
    ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL 
    QKDYSFTIQA YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD 
    SILRVEAVDA DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY 
    DCGKKRATED VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ 
    ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD 
    QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL 
    YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE 
    PFSVTEDYPL HPSKIETQLV VGACWQGGDL HMTQFFRGNL AGLTLRSGKL ADKKVIDCLY 
    TCKEGLDLQV LEDSGRGVQI QAHPSQLVLT LEGEDLGELD KAMQHISYLN SRQFPTPGIR 
    RLKITSTIKC FNEATCISVP PVDGYVMVLQ PEEPKISLSG VHHFARAASE FESSEGVFLF 
    PELRIISTIT REVEPEGDGA EDPTVQESLV SEEIVHDLDT CEVTVEGEEL NHEQESLEVD 
    MARLQQKGIE VSSSELGMTF TGVDTMASYE EVLHLLRYRN WHARSLLDRK FKLICSELNG 
    RYISNEFKVE VNVIHTANPM EHANHMAAQP QFVHPEHRSF VDLSGHNLAN PHPFAVVPST 
    ATVVIVVCVS FLVFMIILGV FRIRAAHRRT MRDQDTGKEN EMDWDDSALT ITVNPMETYE 
    DQHSSEEEEE EEEEEESEDG EEEDDITSAE SESSEEEEGE QGDPQNATRQ QQLEWDDSTL 
    SY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.