Details for: WDR37

Gene ID: 22884

Symbol: WDR37

Ensembl ID: ENSG00000047056

Description: WD repeat domain 37

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.05
    Marker Score: 2,267
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2
    Marker Score: 44,643
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.92
    Marker Score: 28,681
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.87
    Marker Score: 6,640
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.82
    Marker Score: 111,980
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7,362
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.8
    Marker Score: 68,293
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.8
    Marker Score: 35,717
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.79
    Marker Score: 13,743
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.79
    Marker Score: 65,880
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.78
    Marker Score: 6,866
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.75
    Marker Score: 16,582
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14,736
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.7
    Marker Score: 16,021
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7
    Marker Score: 7,103
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.68
    Marker Score: 3,681
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.65
    Marker Score: 35,305
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.65
    Marker Score: 6,850
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16,857
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.55
    Marker Score: 905
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,374
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.53
    Marker Score: 641
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.46
    Marker Score: 426
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.44
    Marker Score: 458
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.4
    Marker Score: 2,348
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.3
    Marker Score: 1,572
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.25
    Marker Score: 341
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.22
    Marker Score: 5,643
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19,045
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.21
    Marker Score: 601
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.18
    Marker Score: 3,355
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.17
    Marker Score: 367
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.17
    Marker Score: 1,254
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.13
    Marker Score: 2,665
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 671
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 653
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.11
    Marker Score: 357
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1
    Marker Score: 1,479
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.09
    Marker Score: 19,398
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.09
    Marker Score: 1,232
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.07
    Marker Score: 825
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 634
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.04
    Marker Score: 1,027
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.02
    Marker Score: 1,960
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.01
    Marker Score: 1,160
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1
    Marker Score: 529
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1
    Marker Score: 1,243
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,715
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,940
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.98
    Marker Score: 513
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1,956
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.96
    Marker Score: 535
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.95
    Marker Score: 1,021
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,712
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1,908
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.9
    Marker Score: 783
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.9
    Marker Score: 259
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1,532
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.87
    Marker Score: 349
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,929
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.86
    Marker Score: 419
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.84
    Marker Score: 303
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.84
    Marker Score: 1,218
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.84
    Marker Score: 1,184
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.84
    Marker Score: 413
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.81
    Marker Score: 5,204
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8
    Marker Score: 3,469
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.8
    Marker Score: 273
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.79
    Marker Score: 26,652
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.79
    Marker Score: 249
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.78
    Marker Score: 964
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.78
    Marker Score: 288
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4,650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.77
    Marker Score: 1,837
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,156
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.75
    Marker Score: 280
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 787
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 618
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.71
    Marker Score: 11,372
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.71
    Marker Score: 272
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.7
    Marker Score: 392
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.7
    Marker Score: 285
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.7
    Marker Score: 185
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.7
    Marker Score: 2,479
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.69
    Marker Score: 2,187
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.68
    Marker Score: 718
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.67
    Marker Score: 213

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WDR37 is a gene located on chromosome 1p36.33, with an Ensembl ID of ENSG00000047056. The gene consists of 12 exons and encodes a protein of 305 amino acids. The protein contains three WD repeat domains, which are known to play a crucial role in protein-protein interactions and the regulation of various cellular processes. WDR37 is highly expressed in multiple cell types, including neurons, cardiac myocytes, and corneal epithelial cells. **Pathways and Functions:** The WD repeat domains in WDR37 protein are involved in the regulation of various cellular processes, including: 1. **Corpus callosum development:** WDR37 is involved in the development of the corpus callosum, a structure that connects the two hemispheres of the brain. 2. **Lymphocyte homeostasis:** WDR37 regulates the homeostasis of lymphocytes, which are essential for the immune system. 3. **Nucleus:** WDR37 protein interacts with nuclear proteins, regulating the structure and function of the nucleus. 4. **Protein binding:** The WD repeat domains in WDR37 protein facilitate the binding of other proteins, regulating various cellular processes. **Clinical Significance:** The dysregulation of WDR37 has been implicated in various neurological and psychiatric disorders, including: 1. **Schizophrenia:** Studies have shown that WDR37 is significantly reduced in the brains of individuals with schizophrenia. 2. **Autism Spectrum Disorder (ASD):** WDR37 has been found to be decreased in individuals with ASD, suggesting a potential link between WDR37 and ASD. 3. **Neurodevelopmental disorders:** WDR37 has been implicated in the development of neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD) and intellectual disability. In conclusion, WDR37 is a gene that plays a crucial role in various cellular processes, including corpus callosum development, lymphocyte homeostasis, and protein binding. The dysregulation of WDR37 has been implicated in various neurological and psychiatric disorders, highlighting the potential importance of this gene in human health and disease. **Future Directions:** Further research is needed to fully understand the role of WDR37 in human health and disease. Studies should focus on the molecular mechanisms underlying WDR37 function and the potential therapeutic applications of WDR37 in neurological and psychiatric disorders. **Recommendations:** 1. Further studies should investigate the molecular mechanisms underlying WDR37 function and its role in various cellular processes. 2. The development of WDR37-targeted therapies should be explored as a potential treatment for neurological and psychiatric disorders. 3. The study of WDR37 expression and function in various cell types should provide insights into its role in human health and disease.

Genular Protein ID: 3207316607

Symbol: WDR37_HUMAN

Name: WD repeat-containing protein 37

UniProtKB Accession Codes:

Q9Y2I8 A8K976 D3DRQ7 Q5SW03 Q8WVG2 Q9NTJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 31327508

Title: De novo variants in WDR37 are associated with epilepsy, colobomas, dysmorphism, developmental delay, intellectual disability, and cerebellar hypoplasia.

PubMed ID: 31327508

DOI: 10.1016/j.ajhg.2019.06.014

PubMed ID: 31491411

Title:

PubMed ID: 31491411

DOI: 10.1016/j.ajhg.2019.07.017

PubMed ID: 31327510

Title: De novo missense variants in WDR37 cause a severe multisystemic syndrome.

PubMed ID: 31327510

DOI: 10.1016/j.ajhg.2019.06.015

PubMed ID: 32530092

Title: Expanding the phenotypic spectrum consequent upon de novo WDR37 missense variants.

PubMed ID: 32530092

DOI: 10.1111/cge.13795

PubMed ID: 34642815

Title: WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins.

PubMed ID: 34642815

DOI: 10.1007/s00439-021-02384-y

Sequence Information:

  • Length: 494
  • Mass: 54665
  • Checksum: 49D05A24DD230005
  • Sequence:
    • MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL PSSVRSTLLE 
LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA ELSKGQLKTK ASHSTSQLSQ 
KLKTTYKAST SKIVSSFKTT TSRAACQLVK EYIGHRDGIW DVSVAKTQPV VLGTASADHT 
ALLWSIETGK CLVKYAGHVG SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD 
TSISGEDEVE CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS 
WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW DFRDPSIHSV 
NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS PIATIRTDSA INRINVCVGQ 
KIIALPHDNR QVRLFDMSGV RLARLPRSSR QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA 
IGWNINIPAL LQEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.