Details for: ABLIM3

Gene ID: 22885

Symbol: ABLIM3

Ensembl ID: ENSG00000173210

Description: actin binding LIM protein family member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.07
    Marker Score: 4,055
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.43
    Marker Score: 3,356
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18,347
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.95
    Marker Score: 10,472
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.88
    Marker Score: 7,813
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.78
    Marker Score: 60,097
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.76
    Marker Score: 65,003
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.75
    Marker Score: 11,232
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.73
    Marker Score: 6,165
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.71
    Marker Score: 33,945
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7
    Marker Score: 6,562
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.7
    Marker Score: 7,319
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.69
    Marker Score: 25,239
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.65
    Marker Score: 6,703
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.64
    Marker Score: 14,110
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15,189
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.58
    Marker Score: 16,343
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.54
    Marker Score: 58,463
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.51
    Marker Score: 582
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.5
    Marker Score: 11,496
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.47
    Marker Score: 90,589
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,504
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.44
    Marker Score: 3,401
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,181
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2,759
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.35
    Marker Score: 30,201
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.35
    Marker Score: 757
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,624
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3
    Marker Score: 408
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.29
    Marker Score: 1,382
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.28
    Marker Score: 1,589
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.21
    Marker Score: 3,462
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2
    Marker Score: 1,329
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.18
    Marker Score: 444
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.12
    Marker Score: 5,889
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 666
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.05
    Marker Score: 4,872
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.03
    Marker Score: 1,502
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,321
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.93
    Marker Score: 924
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3,289
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5,521
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.91
    Marker Score: 380
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.91
    Marker Score: 504
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 570
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.86
    Marker Score: 652
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1,598
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 493
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.81
    Marker Score: 698
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 531
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.75
    Marker Score: 280
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 491
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 836
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.72
    Marker Score: 887
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.71
    Marker Score: 349
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.7
    Marker Score: 294
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.69
    Marker Score: 1,022
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.69
    Marker Score: 1,589
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.68
    Marker Score: 14,607
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.68
    Marker Score: 163
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 217
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.66
    Marker Score: 181
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.65
    Marker Score: 313
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.63
    Marker Score: 395
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.62
    Marker Score: 132
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.61
    Marker Score: 2,002
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.61
    Marker Score: 2,034
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6
    Marker Score: 314
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.59
    Marker Score: 626
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 258
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.57
    Marker Score: 4,301
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 115
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.57
    Marker Score: 872
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 449
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.56
    Marker Score: 163
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.54
    Marker Score: 318
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.53
    Marker Score: 293
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.53
    Marker Score: 478
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.53
    Marker Score: 473
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.52
    Marker Score: 524
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.52
    Marker Score: 651
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.51
    Marker Score: 139
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.49
    Marker Score: 285
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.48
    Marker Score: 219
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.48
    Marker Score: 234

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABLIM3, a protein encoded by the ABLIM3 gene, is a member of the LIM-only protein family, characterized by its unique LIM domains. These domains are crucial for binding to actin filaments, thereby modulating cytoskeletal dynamics and influencing cellular processes. ABLIM3's expression is widespread, with significant levels detected in various cell types, including those involved in the nervous system, liver, and heart. This widespread expression suggests a multifaceted role in maintaining cellular homeostasis. **Pathways and Functions:** ABLIM3's involvement in multiple pathways underscores its diverse functions. These include: 1. **Actin Cytoskeleton and Filament Binding:** ABLIM3's LIM domains facilitate its binding to actin filaments, influencing cytoskeletal dynamics and organization. 2. **Axon Guidance and Cilium Assembly:** ABLIM3's role in axon guidance and cilium assembly highlights its significance in neural development and function. 3. **Cytoplasmic Organization and Stress Fiber Formation:** ABLIM3's involvement in cytoplasmic organization and stress fiber formation underscores its role in maintaining cellular structure and responding to stress. 4. **Transcriptional Regulation:** ABLIM3's positive regulation of transcription by RNA polymerase II suggests its potential role in modulating gene expression. 5. **Protein Targeting to Mitochondria and Synaptic Function:** ABLIM3's involvement in protein targeting to mitochondria and synaptic function highlights its significance in maintaining cellular energy homeostasis and neuronal function. **Clinical Significance:** The clinical significance of ABLIM3 lies in its potential role in various diseases and disorders. Research has implicated ABLIM3 in: 1. **Neurodevelopmental Disorders:** ABLIM3's role in axon guidance and cilium assembly suggests its potential involvement in neurodevelopmental disorders, such as autism and schizophrenia. 2. **Neurodegenerative Diseases:** ABLIM3's involvement in synaptic function and protein targeting to mitochondria may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cardiac Disease:** ABLIM3's expression in cardiac myocytes and its role in maintaining cytoskeletal dynamics may contribute to cardiac function and disease. In conclusion, ABLIM3's intricate role in various cellular processes underscores its significance in maintaining cellular homeostasis and regulating physiological functions. Further research is necessary to fully elucidate the clinical significance of ABLIM3 and its potential role in various diseases and disorders.

Genular Protein ID: 3010258631

Symbol: ABLM3_HUMAN

Name: Actin-binding LIM protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 17194709

Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.

PubMed ID: 17194709

DOI: 10.1074/jbc.m607549200

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15221005

Title: Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.

PubMed ID: 15221005

DOI: 10.1038/sj.onc.1207782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 683
  • Mass: 77802
  • Checksum: 0392DBD9065EE08A
  • Sequence:
  • MNTSIPYQQN PYNPRGSSNV IQCYRCGDTC KGEVVRVHNN HFHIRCFTCQ VCGCGLAQSG 
    FFFKNQEYIC TQDYQQLYGT RCDSCRDFIT GEVISALGRT YHPKCFVCSL CRKPFPIGDK 
    VTFSGKECVC QTCSQSMASS KPIKIRGPSH CAGCKEEIKH GQSLLALDKQ WHVSCFKCQT 
    CSVILTGEYI SKDGVPYCES DYHAQFGIKC ETCDRYISGR VLEAGGKHYH PTCARCVRCH 
    QMFTEGEEMY LTGSEVWHPI CKQAARAEKK LKHRRTSETS ISPPGSSIGS PNRVICAKVD 
    NEILNYKDLA ALPKVKSIYE VQRPDLISYE PHSRYMSDEM LERCGYGESL GTLSPYSQDI 
    YENLDLRQRR ASSPGYIDSP TYSRQGMSPT FSRSPHHYYR SGPESGRSSP YHSQLDVRSS 
    TPTSYQAPKH FHIPAGDSNI YRKPPIYKRH GDLSTATKSK TSEDISQTSK YSPIYSPDPY 
    YASESEYWTY HGSPKVPRAR RFSSGGEEDD FDRSMHKLQS GIGRLILKEE MKARSSSYAD 
    PWTPPRSSTS SREALHTAGY EMSLNGSPRS HYLADSDPLI SKSASLPAYR RNGLHRTPSA 
    DLFHYDSMNA VNWGMREYKI YPYELLLVTT RGRNRLPKDV DRTRLERHLS QEEFYQVFGM 
    TISEFDRLAL WKRNELKKQA RLF

Genular Protein ID: 3235958046

Symbol: A0A0C4DGA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 650
  • Mass: 74168
  • Checksum: 55482F36E636D695
  • Sequence:
  • MNTSIPYQQN PYNPRGSSNV IQCYRCGDTC KGEVVRVHNN HFHIRCFTCQ VCGCGLAQSG 
    FFFKNQEYIC TQDYQQLYGT RCDSCRDFIT GEVISALGRT YHPKCFVCSL CRKPFPIGDK 
    VTFSGKECVC QTCSQSMASS KPIKIRGPSH CAGCKEEIKH GQSLLALDKQ WHVSCFKCQT 
    CSVILTGEYI SKDGVPYCES DYHAQFGIKC ETCDRYISGR VLEAGGKHYH PTCARCVRCH 
    QMFTEGEEMY LTGSEVWHPI CKQAARAEKK LKHRRTSETS ISPPGSSIGS PNRVICAKVD 
    NEILNYKDLA ALPKVKSIYE VQRPDLISYE PHSRYMSDEM LERCGYGESL GTLSPYSQDI 
    YENLDLRQRR ASSPGYIDSP TYSRQGMSPT FSRSPHHYYR SAGDSNIYRK PPIYKRHGDL 
    STATKSKTSE DISQTSKYSP IYSPDPYYAS ESEYWTYHGS PKVPRARRFS SGGEEDDFDR 
    SMHKLQSGIG RLILKEEMKA RSSSYADPWT PPRSSTSSRE ALHTAGYEMS LNGSPRSHYL 
    ADSDPLISKS ASLPAYRRNG LHRTPSADLF HYDSMNAVNW GMREYKIYPY ELLLVTTRGR 
    NRLPKDVDRT RLERHLSQEE FYQVFGMTIS EFDRLALWKR NELKKQARLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.