Details for: FOXJ3

Gene ID: 22887

Symbol: FOXJ3

Ensembl ID: ENSG00000198815

Description: forkhead box J3

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Male meiosis i
    (GO:0007141)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatogenesis
    (GO:0007283)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.62
    Marker Score: 3,525
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.49
    Marker Score: 8,865
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.49
    Marker Score: 3,010
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.36
    Marker Score: 1,378
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.3
    Marker Score: 2,870
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.28
    Marker Score: 50,972
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.28
    Marker Score: 9,543
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.11
    Marker Score: 2,428
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79,395
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.08
    Marker Score: 1,849
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.03
    Marker Score: 43,373
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.02
    Marker Score: 589
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.01
    Marker Score: 919
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.01
    Marker Score: 40,016
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2
    Marker Score: 15,312
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2
    Marker Score: 29,859
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.99
    Marker Score: 73,296
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.95
    Marker Score: 8,098
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.93
    Marker Score: 1,124
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.91
    Marker Score: 7,374
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.91
    Marker Score: 4,185
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.9
    Marker Score: 8,792
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9
    Marker Score: 1,319
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.88
    Marker Score: 1,051
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.86
    Marker Score: 114,478
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.84
    Marker Score: 3,214
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.82
    Marker Score: 17,141
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.81
    Marker Score: 1,998
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.79
    Marker Score: 752
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.79
    Marker Score: 2,028
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.78
    Marker Score: 3,431
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.78
    Marker Score: 1,462
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,879
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.76
    Marker Score: 1,356
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.74
    Marker Score: 14,957
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.68
    Marker Score: 1,003
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.68
    Marker Score: 17,304
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.65
    Marker Score: 4,711
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.63
    Marker Score: 4,085
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.62
    Marker Score: 855
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.6
    Marker Score: 6,522
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.6
    Marker Score: 505
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.57
    Marker Score: 575
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.57
    Marker Score: 498
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.56
    Marker Score: 52,541
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.54
    Marker Score: 864
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.52
    Marker Score: 1,642
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,350
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.49
    Marker Score: 809
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.47
    Marker Score: 23,592
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.47
    Marker Score: 967
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.45
    Marker Score: 2,435
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.43
    Marker Score: 696
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.43
    Marker Score: 793
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.42
    Marker Score: 388
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.4
    Marker Score: 697
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.39
    Marker Score: 1,326
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.38
    Marker Score: 500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.38
    Marker Score: 24,446
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.37
    Marker Score: 901
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1,672
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.34
    Marker Score: 341
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.33
    Marker Score: 3,174
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.32
    Marker Score: 1,145
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.32
    Marker Score: 380
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.31
    Marker Score: 4,308
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.3
    Marker Score: 5,405
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.27
    Marker Score: 1,533
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.25
    Marker Score: 1,316
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.24
    Marker Score: 423
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.23
    Marker Score: 460
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.22
    Marker Score: 920
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.22
    Marker Score: 442
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.22
    Marker Score: 7,815
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18,906
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2
    Marker Score: 462
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.19
    Marker Score: 1,730
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2,781
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.18
    Marker Score: 1,667
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.17
    Marker Score: 6,297
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.16
    Marker Score: 437
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.16
    Marker Score: 1,004
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.15
    Marker Score: 426
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.15
    Marker Score: 568
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.15
    Marker Score: 4,953
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.13
    Marker Score: 658
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.12
    Marker Score: 5,890
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.12
    Marker Score: 1,195
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.08
    Marker Score: 343
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.07
    Marker Score: 5,746
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.06
    Marker Score: 3,768
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.05
    Marker Score: 1,113
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.04
    Marker Score: 274
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.03
    Marker Score: 2,526
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.02
    Marker Score: 3,427
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.02
    Marker Score: 264
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1,310
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1
    Marker Score: 1,067
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,637
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,861

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXJ3 is a member of the forkhead box (FOX) family of transcription factors, which are known for their role in regulating gene expression. FOXJ3 is specifically expressed in various cell types, including anterior lens cells, cardiac neurons, and vascular leptomeningeal cells. The gene is also significant in the context of male meiosis and spermatogenesis. FOXJ3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation, and has been implicated in the regulation of transcription by RNA polymerase II. **Pathways and Functions:** FOXJ3 is involved in several key pathways, including: 1. **Cell Differentiation:** FOXJ3 plays a crucial role in regulating cell differentiation, particularly in the context of immune cell development. Studies have shown that FOXJ3 is involved in the regulation of T cell development and function. 2. **Transcription Regulation:** FOXJ3 interacts with RNA polymerase II to regulate transcriptional activity. This interaction is essential for the proper functioning of immune cells and the regulation of immune responses. 3. **DNA Binding:** FOXJ3 has been shown to bind to specific DNA sequences, which is essential for its role in regulating gene expression. **Clinical Significance:** FOXJ3 has been implicated in several immune-related disorders, including: 1. **Autoimmune Diseases:** Studies have shown that FOXJ3 is involved in the regulation of immune responses and may play a role in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Immunodeficiency Disorders:** FOXJ3 has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where there is a defect in T cell development and function. 3. **Cancer:** FOXJ3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it may play a role in tumorigenesis. In conclusion, FOXJ3 is a critical transcription factor that plays a significant role in regulating immune cell development, function, and responses to pathogens. Further studies are needed to fully understand the mechanisms by which FOXJ3 regulates immune responses and to explore its potential as a therapeutic target for immune-related disorders. **References:** * [Insert relevant references] Note: As an expert immunologist, I would like to emphasize the importance of further research on FOXJ3 to fully understand its role in the immune system and to explore its potential as a therapeutic target for immune-related disorders.

Genular Protein ID: 1602871711

Symbol: FOXJ3_HUMAN

Name: Forkhead box protein J3

UniProtKB Accession Codes:

Q9UPW0 A7MBL7 A7MD18 D3DPW2 Q9NSS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 622
  • Mass: 68960
  • Checksum: 2C53E63C76AF057B
  • Sequence:
    • MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG TGISKKNALL 
DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT LSEIYQWICD NFPYYREAGS 
GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS YWAIDTNPKE DVLPTRPKKR ARSVERASTP 
YSIDSDSLGM ECIISGSASP TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV 
NLNSVGSVHS YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY 
KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS NSHGSGLNTT 
GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP APHPQQHSQL QSPHPQHPSP 
HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS GVSNDWYATL DMLKESCRIA SSVNWSDVDL 
SQFQGLMESM RQADLKNWSL DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT 
KPSQHIGTGN LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA 
FQMRRSLPPD DIQDDFDWDS IV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.