Details for: UBOX5

Gene ID: 22888

Symbol: UBOX5

Ensembl ID: ENSG00000185019

Description: U-box domain containing 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.16
    Marker Score: 1,070
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1,424
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,109
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13,842
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.85
    Marker Score: 8,809
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.85
    Marker Score: 52,458
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.83
    Marker Score: 1,959
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.81
    Marker Score: 7,725
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6,889
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7,300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,241
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1,440
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.76
    Marker Score: 27,855
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1,432
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,951
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.67
    Marker Score: 2,592
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.66
    Marker Score: 275
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1,112
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.63
    Marker Score: 9,467
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.62
    Marker Score: 23,402
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.61
    Marker Score: 12,148
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.61
    Marker Score: 2,516
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.58
    Marker Score: 4,441
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.58
    Marker Score: 2,413
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3,453
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.53
    Marker Score: 145
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5
    Marker Score: 2,114
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.47
    Marker Score: 10,090
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.45
    Marker Score: 1,823
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.44
    Marker Score: 355
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.44
    Marker Score: 142
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 246
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.43
    Marker Score: 173
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.43
    Marker Score: 516
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.43
    Marker Score: 470
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 255
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.41
    Marker Score: 7,264
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4
    Marker Score: 233
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.38
    Marker Score: 833
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.36
    Marker Score: 1,412
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 236
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.35
    Marker Score: 377
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.34
    Marker Score: 663
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 341
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 382
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.33
    Marker Score: 408
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.32
    Marker Score: 1,146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 134
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.32
    Marker Score: 226
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 274
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.31
    Marker Score: 80
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.31
    Marker Score: 169
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.31
    Marker Score: 149
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.31
    Marker Score: 1,415
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 188
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.29
    Marker Score: 722
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.28
    Marker Score: 401
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.28
    Marker Score: 405
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.28
    Marker Score: 468
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 113
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 207
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.27
    Marker Score: 369
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.27
    Marker Score: 151
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.27
    Marker Score: 5,955
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.26
    Marker Score: 279
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.26
    Marker Score: 253
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.26
    Marker Score: 625
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.26
    Marker Score: 334
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 76
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.26
    Marker Score: 75
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.26
    Marker Score: 1,069

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBOX5 is a ubiquitin ligase protein that contains a U-box domain, a specific structural motif that enables its interaction with ubiquitin. The U-box domain is characterized by a conserved sequence of amino acids, which is essential for the recognition and binding of ubiquitin. UBOX5 is highly expressed in various cell types, including immune cells, neurons, and epithelial cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** UBOX5 is implicated in several pathways, including: 1. **Adaptive Immune System**: UBOX5 is involved in the regulation of immune responses, particularly in the processing and presentation of antigens to T-cells. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation**: UBOX5 facilitates the ubiquitination and degradation of proteins, which is essential for the presentation of antigens to the immune system. 3. **Class I MHC Mediated Antigen Processing & Presentation**: UBOX5 is involved in the processing and presentation of antigens to CD8+ T-cells via Class I MHC molecules. 4. **Focal Adhesion**: UBOX5 regulates cell adhesion and migration, which is essential for immune cell function and tissue repair. 5. **Protein Polyubiquitination**: UBOX5 is involved in the regulation of protein degradation and turnover, which is critical for maintaining protein homeostasis. **Clinical Significance:** Dysregulation of UBOX5 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: UBOX5 has been shown to play a role in the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: UBOX5 has been implicated in cancer progression and metastasis, particularly in the degradation of tumor suppressor proteins. 3. **Neurological Disorders**: UBOX5 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates protein degradation and clearance. In conclusion, the UBOX5 gene plays a crucial role in the regulation of protein degradation, ubiquitination, and antigen processing, which are essential mechanisms for maintaining protein homeostasis and regulating various cellular functions. Dysregulation of UBOX5 has been implicated in various diseases, highlighting its importance in human health and disease. Further research is needed to fully elucidate the mechanisms of UBOX5 and its role in human disease.

Genular Protein ID: 3103400358

Symbol: RNF37_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94941 Q6IAR5 Q86X87 Q9H4J2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10431818

Title: A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4.

PubMed ID: 10431818

DOI: 10.1016/s0014-5793(99)00823-6

PubMed ID: 11274149

Title: Interaction of the RING finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes.

PubMed ID: 11274149

DOI: 10.1074/jbc.m100192200

PubMed ID: 11435423

Title: U box proteins as a new family of ubiquitin-protein ligases.

PubMed ID: 11435423

DOI: 10.1074/jbc.m102755200

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 541
  • Mass: 58966
  • Checksum: 4AF1A0C5115FAF7B
  • Sequence:
    • MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN 
VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK 
VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV 
TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP 
ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG 
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP 
SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP 
LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG 
PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH 
F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.