Details for: ZBTB1

Gene ID: 22890

Symbol: ZBTB1

Ensembl ID: ENSG00000126804

Description: zinc finger and BTB domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.12
    Marker Score: 2,436
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.85
    Marker Score: 39,381
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.8
    Marker Score: 776
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.78
    Marker Score: 65,556
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.74
    Marker Score: 2,407
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.72
    Marker Score: 25,787
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6,462
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5
    Marker Score: 876
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.46
    Marker Score: 4,083
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.43
    Marker Score: 13,454
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.43
    Marker Score: 54,314
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.42
    Marker Score: 5,497
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.42
    Marker Score: 5,768
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14,600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.39
    Marker Score: 13,244
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.39
    Marker Score: 407
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.39
    Marker Score: 11,936
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.37
    Marker Score: 84,547
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.37
    Marker Score: 2,636
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.36
    Marker Score: 27,038
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2,086
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.34
    Marker Score: 2,933
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.3
    Marker Score: 482
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.29
    Marker Score: 1,396
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.29
    Marker Score: 399
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.25
    Marker Score: 3,044
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.23
    Marker Score: 9,432
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.22
    Marker Score: 609
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2
    Marker Score: 5,004
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.18
    Marker Score: 705
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.18
    Marker Score: 1,735
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.18
    Marker Score: 1,298
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.15
    Marker Score: 672
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.15
    Marker Score: 1,687
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.14
    Marker Score: 664
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17,174
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.09
    Marker Score: 1,319
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.07
    Marker Score: 6,484
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.07
    Marker Score: 873
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.06
    Marker Score: 776
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.06
    Marker Score: 974
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.05
    Marker Score: 906
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.04
    Marker Score: 505
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.03
    Marker Score: 907
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.03
    Marker Score: 292
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1,028
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.01
    Marker Score: 3,194
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.01
    Marker Score: 1,221
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1
    Marker Score: 604
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1
    Marker Score: 1,417
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1
    Marker Score: 933
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,608
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,833
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.98
    Marker Score: 488
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,378
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.98
    Marker Score: 602
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.97
    Marker Score: 211
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 392
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.97
    Marker Score: 231
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.96
    Marker Score: 857
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.96
    Marker Score: 1,198
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.96
    Marker Score: 340
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.96
    Marker Score: 805
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.96
    Marker Score: 1,604
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.95
    Marker Score: 1,038
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 572
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.95
    Marker Score: 546
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.95
    Marker Score: 2,618
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.95
    Marker Score: 305
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.94
    Marker Score: 715
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1,336
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.94
    Marker Score: 642
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.94
    Marker Score: 352
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.94
    Marker Score: 525
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,385
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.94
    Marker Score: 296
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.93
    Marker Score: 379
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.92
    Marker Score: 1,190
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.92
    Marker Score: 202
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.92
    Marker Score: 1,231
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.91
    Marker Score: 179
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.91
    Marker Score: 613
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.91
    Marker Score: 578
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.91
    Marker Score: 314
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 956
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.9
    Marker Score: 903
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.9
    Marker Score: 855
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,686
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.89
    Marker Score: 1,866
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.89
    Marker Score: 1,584
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1,543
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.88
    Marker Score: 217
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.88
    Marker Score: 3,775
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.88
    Marker Score: 368
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.88
    Marker Score: 306
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.87
    Marker Score: 7,661
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.87
    Marker Score: 261

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger and BTB Domain**: ZBTB1 contains a characteristic zinc finger and BTB (Brahma, TFIID, and Spt-1) domain, which is crucial for its DNA-binding and transcriptional regulatory activities. 2. **Transcriptional Repression and Regulation**: ZBTB1 exhibits both transcriptional repressive and regulatory activities, influencing the expression of various genes involved in immune responses, cellular differentiation, and chromatin remodeling. 3. **Cellular Specificity**: ZBTB1 is highly expressed in specific cell types, including T cells, B cells, natural killer cells, and neural cells, underscoring its unique role in regulating immune responses and cellular differentiation. **Pathways and Functions:** 1. **B Cell Differentiation**: ZBTB1 plays a crucial role in the regulation of B cell differentiation, influencing the expression of genes involved in B cell development and maturation. 2. **Chromatin Remodeling**: ZBTB1's zinc finger and BTB domain enable it to interact with chromatin remodeling complexes, facilitating the remodeling of chromatin structure and gene expression. 3. **DNA Damage Response**: ZBTB1 is involved in the regulation of DNA damage response pathways, influencing the expression of genes involved in DNA repair and cell cycle regulation. 4. **Immune System Regulation**: ZBTB1's transcriptional regulatory activities influence the expression of genes involved in immune responses, including cytokine production, T cell differentiation, and natural killer cell activation. 5. **Neural Development and Function**: ZBTB1's expression in neural cells highlights its role in regulating neural development, synaptic plasticity, and neural circuit function. **Clinical Significance:** 1. **Immune-Related Disorders**: ZBTB1's dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. 2. **Cancer**: ZBTB1's role in regulating cellular differentiation and immune responses makes it a potential target for cancer therapy. 3. **Neurological Disorders**: ZBTB1's expression in neural cells and its involvement in neural development and function make it a potential target for the treatment of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Gene Therapy**: ZBTB1's unique transcriptional regulatory activities and cellular specificity make it an attractive target for gene therapy approaches aimed at regulating immune responses and cellular differentiation. In conclusion, ZBTB1 is a complex gene that plays a pivotal role in regulating immune responses, cellular differentiation, and chromatin remodeling. Its dysregulation has been implicated in various immune-related disorders, and its unique transcriptional regulatory activities make it an attractive target for gene therapy approaches. Further research is necessary to fully elucidate the mechanisms by which ZBTB1 regulates immune responses and cellular differentiation, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1653594502

Symbol: ZBTB1_HUMAN

Name: Zinc finger and BTB domain-containing protein 1

UniProtKB Accession Codes:

Q9Y2K1 A8K6S8 Q86SW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 7 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20797634

Title: Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.

PubMed ID: 20797634

DOI: 10.1016/j.molcel.2010.07.026

PubMed ID: 21706167

Title: Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE.

PubMed ID: 21706167

DOI: 10.1007/s11010-011-0911-5

PubMed ID: 22753936

Title: Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development.

PubMed ID: 22753936

DOI: 10.4049/jimmunol.1200623

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24657165

Title: Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.

PubMed ID: 24657165

DOI: 10.1016/j.molcel.2014.02.017

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 713
  • Mass: 82016
  • Checksum: 4B120DD45FA14305
  • Sequence:
    • MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST 
AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD 
CSSSKCSSSA SSKQNSKMIF GVRMYEDTVA RNGNEANRWC AEPSSTVNTP HNREADEESL 
QLGNFPEPLF DVCKKSSVSK LSTPKERVSR RFGRSFTCDS CGFGFSCEKL LDEHVLTCTN 
RHLYQNTRSY HRIVDIRDGK DSNIKAEFGE KDSSKTFSAQ TDKYRGDTSQ AADDSASTTG 
SRKSSTVESE IASEEKSRAA ERKRIIIKME PEDIPTDELK DFNIIKVTDK DCNESTDNDE 
LEDEPEEPFY RYYVEEDVSI KKSGRKTLKP RMSVSADERG GLENMRPPNN SSPVQEDAEN 
ASCELCGLTI TEEDLSSHYL AKHIENICAC GKCGQILVKG RQLQEHAQRC GEPQDLTMNG 
LGNTEEKMDL EENPDEQSEI RDMFVEMLDD FRDNHYQINS IQKKQLFKHS ACPFRCPNCG 
QRFETENLVV EHMSSCLDQD MFKSAIMEEN ERDHRRKHFC NLCGKGFYQR CHLREHYTVH 
TKEKQFVCQT CGKQFLRERQ LRLHNDMHKG MARYVCSICD QGNFRKHDHV RHMISHLSAG 
ETICQVCFQI FPNNEQLEQH MDVHLYTCGI CGAKFNLRKD MRSHYNAKHL KRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.