Details for: BAHD1

Gene ID: 22893

Symbol: BAHD1

Ensembl ID: ENSG00000140320

Description: bromo adjacent homology domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.05
    Marker Score: 1,829
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,787
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15,608
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,087
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 2,006
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.78
    Marker Score: 13,917
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.75
    Marker Score: 1,578
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.74
    Marker Score: 2,746
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.74
    Marker Score: 7,620
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 564
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.73
    Marker Score: 790
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,913
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 628
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 987
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.64
    Marker Score: 2,468
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.64
    Marker Score: 434
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 374
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.61
    Marker Score: 1,032
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1,206
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 181
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.58
    Marker Score: 530
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.57
    Marker Score: 21,683
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3,297
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.53
    Marker Score: 19,556
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.51
    Marker Score: 3,925
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.5
    Marker Score: 10,646
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.5
    Marker Score: 493
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.49
    Marker Score: 2,003
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.49
    Marker Score: 4,196
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 305
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.47
    Marker Score: 28,805
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.46
    Marker Score: 4,363
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.44
    Marker Score: 384
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.44
    Marker Score: 450
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.44
    Marker Score: 634
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.4
    Marker Score: 8,027
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.4
    Marker Score: 208
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4
    Marker Score: 2,349
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4
    Marker Score: 3,979
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 563
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.38
    Marker Score: 475
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.38
    Marker Score: 224
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.37
    Marker Score: 404
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.37
    Marker Score: 426
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.37
    Marker Score: 1,516
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.36
    Marker Score: 374
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.36
    Marker Score: 146
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.36
    Marker Score: 5,353
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.36
    Marker Score: 310
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.36
    Marker Score: 144
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 376
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 198
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.35
    Marker Score: 366
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 183
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 482
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 150
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.34
    Marker Score: 908
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.33
    Marker Score: 163
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 299
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.33
    Marker Score: 235
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.33
    Marker Score: 221
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.33
    Marker Score: 397
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.33
    Marker Score: 2,892
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.33
    Marker Score: 5,288
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.33
    Marker Score: 2,141
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.33
    Marker Score: 827
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.32
    Marker Score: 198
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.32
    Marker Score: 343
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 531
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.32
    Marker Score: 187
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.32
    Marker Score: 338
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.32
    Marker Score: 1,085
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.31
    Marker Score: 69
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.3
    Marker Score: 1,409
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3
    Marker Score: 336
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.29
    Marker Score: 918
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 108
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.29
    Marker Score: 9,824
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.29
    Marker Score: 69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BAHD1 is a 1,444-amino acid protein that belongs to the BAHD family of chromatin-associated proteins. Its unique structural features, including a bromo adjacent homology domain, enable it to interact with chromatin and other proteins, modulating chromatin dynamics and transcriptional regulation. BAHD1's expression is characterized by a high degree of cell-type specificity, with significant expression in germ cells, neural cells, and intestinal epithelial cells, underscoring its role in tissue-specific development and function. **Pathways and Functions:** BAHD1 is involved in various chromatin-related pathways, including: 1. **Chromatin Binding:** BAHD1 interacts with chromatin, influencing the formation and maintenance of heterochromatin, a compact and transcriptionally repressed chromatin structure. 2. **Chromatin Silencing Complex:** BAHD1 is a component of the chromatin silencing complex, which regulates gene expression by promoting the assembly of repressive chromatin structures. 3. **Heterochromatin Formation:** BAHD1 contributes to the formation of heterochromatin, a critical process in maintaining genome stability and preventing aberrant gene expression. 4. **Negative Regulation of DNA-templated Transcription:** BAHD1 modulates the activity of transcriptional regulators, influencing the balance between active and repressed transcription. 5. **Protein Binding:** BAHD1 interacts with a range of proteins, including histone-modifying enzymes, transcription factors, and chromatin-associated proteins, to regulate chromatin dynamics and gene expression. **Clinical Significance:** Dysregulation of BAHD1 has been implicated in various diseases, including: 1. **Neurological Disorders:** BAHD1 mutations have been linked to neurological disorders, such as autism spectrum disorder and schizophrenia, highlighting the gene's role in neural development and function. 2. **Cancer:** BAHD1's involvement in chromatin regulation and transcriptional control suggests its potential as a therapeutic target in cancer, where aberrant gene expression and chromatin dynamics contribute to tumorigenesis. 3. **Intestinal Diseases:** BAHD1's expression in intestinal epithelial cells and its role in maintaining intestinal homeostasis suggest its potential as a biomarker or therapeutic target in intestinal diseases, such as inflammatory bowel disease. In conclusion, BAHD1 is a critical regulator of chromatin structure and transcriptional control, influencing cellular differentiation and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying BAHD1's functions and its potential as a therapeutic target.

Genular Protein ID: 4286526371

Symbol: BAHD1_HUMAN

Name: Bromo adjacent homology domain-containing 1 protein

UniProtKB Accession Codes:

Q8TBE0 Q8NDF7 Q9Y2F4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19666599

Title: Human BAHD1 promotes heterochromatic gene silencing.

PubMed ID: 19666599

DOI: 10.1073/pnas.0901259106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21252314

Title: A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

PubMed ID: 21252314

DOI: 10.1126/science.1200120

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33156908

Title: FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.

PubMed ID: 33156908

DOI: 10.1182/blood.2020007809

Sequence Information:

  • Length: 780
  • Mass: 84652
  • Checksum: DDCAA05DFAA6D982
  • Sequence:
    • MTHTRRKSLP MLSSGLTGRR EPLQMEDSNM EQGVEGVEPG MPESPGHLTG RRKNYPLRKR 
PLVPEKPKAC KVLLTRLENV AGPRSADEAD ELPPDLPKPP SPAPSSEDPG LAQPRKRRLA 
SLNAEALNNL LLEREDTSSL AGTRRSRAGD PHRSRDRDRA TGGWSSSKKR PRLGDLGGGS 
RDLSPEPAPD EGPRRDGDPA PKRLASLNAA AFLKLSQERE LPLRLPRAHA EVDGRSTEPP 
APKAPRPKWP KVNGKNYPKA WQGASSGEAA GPPGWQGCPD EPWPSATPCG PSVQPSHQPL 
SKALESPLGL RPHLPLLMGG QAALKPEPGR PGEESPAPKQ ELHQPSFPTP QLSPLPMPGN 
PADYNGLCVG PELTALGSFY LYCGQEGLQC GGYSPCPMLP EGKLSPVAAP HEEGLLLAPS 
SVPSGTPFQH PPWGSSRYCS SEDTGVNGYS ICGVLPLSVT HAGTTCGGCP YKMPFAAEGC 
RSLGQLEFPL PEAGHPASPA HPLLGCPVPS VPPAAEPVPH LQTPTSEPQT VARACPQSAK 
PPSGSKSGLR TGSSCRHTAR SKAARRPSHP KQPRVQRPRP RRRRRRRTNG WVPVGAACEK 
AVYVLDEPEP AIRKSYQAVE RHGETIRVRD TVLLKSGPRK TSTPYVAKIS ALWENPESGE 
LMMSLLWYYR PEHLQGGRSP SMHEPLQNEV FASRHQDQNS VACIEEKCYV LTFAEYCRFC 
AMAKRRGEGL PSRKTALVPP SADYSTPPHR TVPEDTDPEL VFLCRHVYDF RHGRILKNPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.