Details for: DIS3

Gene ID: 22894

Symbol: DIS3

Ensembl ID: ENSG00000083520

Description: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.37
    Marker Score: 2,016
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.23
    Marker Score: 1,290
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 69,887
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10,769
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.1
    Marker Score: 2,713
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9,470
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.09
    Marker Score: 1,684
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.07
    Marker Score: 21,379
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.07
    Marker Score: 1,138
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38,520
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.02
    Marker Score: 3,949
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.02
    Marker Score: 680
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9,556
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1
    Marker Score: 683
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2,282
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,651
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,874
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.99
    Marker Score: 228
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.99
    Marker Score: 4,117
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.98
    Marker Score: 1,267
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,383
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.95
    Marker Score: 571
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.95
    Marker Score: 933
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,386
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.93
    Marker Score: 35,430
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.93
    Marker Score: 3,426
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 472
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.91
    Marker Score: 1,812
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9
    Marker Score: 3,492
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,682
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.89
    Marker Score: 312
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.89
    Marker Score: 9,213
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.89
    Marker Score: 213
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,961
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.87
    Marker Score: 307
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.86
    Marker Score: 12,924
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.86
    Marker Score: 489
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.85
    Marker Score: 246
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.85
    Marker Score: 3,523
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.85
    Marker Score: 791
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.83
    Marker Score: 205
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3,338
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.81
    Marker Score: 349
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6,155
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.8
    Marker Score: 1,409
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.79
    Marker Score: 8,927
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.79
    Marker Score: 619
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.79
    Marker Score: 1,141
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.79
    Marker Score: 535
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.78
    Marker Score: 903
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.78
    Marker Score: 235
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.78
    Marker Score: 187
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.78
    Marker Score: 496
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 532
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.77
    Marker Score: 26,082
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.76
    Marker Score: 377
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 355
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.76
    Marker Score: 839
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.76
    Marker Score: 171
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.76
    Marker Score: 799
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.75
    Marker Score: 26,135
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 691
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.75
    Marker Score: 305
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.75
    Marker Score: 258
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.75
    Marker Score: 362
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.74
    Marker Score: 215
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.74
    Marker Score: 746
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.74
    Marker Score: 161
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.73
    Marker Score: 252
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.73
    Marker Score: 212
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.72
    Marker Score: 908
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.72
    Marker Score: 567
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6,214
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.72
    Marker Score: 169
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.72
    Marker Score: 1,109
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.71
    Marker Score: 344
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.71
    Marker Score: 355
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 469
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.71
    Marker Score: 4,613
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.71
    Marker Score: 7,147
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.7
    Marker Score: 174
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.7
    Marker Score: 751
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.69
    Marker Score: 155
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.69
    Marker Score: 170
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.69
    Marker Score: 317
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.69
    Marker Score: 750
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.69
    Marker Score: 504
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.69
    Marker Score: 193

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The DIS3 gene is a member of the endoribonuclease family, specifically designated as a 3'-5' exoribonuclease. Its protein product, RRP44, is a component of the cytoplasmic exosome complex, which is responsible for degrading deadenylated mRNAs. DIS3 also exhibits guanyl-nucleotide exchange factor activity, suggesting its involvement in RNA processing and translation regulation. **Pathways and Functions:** DIS3 is involved in several key pathways, including: 1. **RNA decay by 3'-5' exoribonuclease**: DIS3's primary function is to degrade deadenylated mRNAs, which are typically associated with protein degradation or translation repression. 2. **Exosome-mediated RNA processing**: As a component of the cytoplasmic exosome complex, DIS3 regulates the processing and degradation of RNAs in the nucleus and cytoplasm. 3. **Unfolded protein response (UPR)**: DIS3 interacts with TRIPOLIN (TTP), a key regulator of mRNA decay, and PERK, a sensor of endoplasmic reticulum (ER) stress. 4. **Cellular responses to stimuli and stress**: DIS3 is involved in the regulation of gene expression in response to ER stress, butyrate response factor 1 (BRF1) binding, and other cellular stimuli. **Clinical Significance:** The DIS3 gene's dysregulation has been implicated in various human diseases, including: 1. **Muscular dystrophy**: Mutations in DIS3 have been associated with X-linked muscular dystrophy, a genetic disorder characterized by progressive muscle weakness and degeneration. 2. **Neurodegenerative disorders**: DIS3 has been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Cancer**: Dysregulation of DIS3 has been observed in various types of cancer, including pancreatic cancer, suggesting its potential role as a tumor suppressor. In conclusion, the DIS3 gene is a critical regulator of RNA decay and cellular stress response, playing a pivotal role in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which DIS3 regulates RNA decay and its implications in human disease.

Genular Protein ID: 2773712452

Symbol: RRP44_HUMAN

Name: Exosome complex exonuclease RRP44

UniProtKB Accession Codes:

Q9Y2L1 A6NI21 B2RBL2 Q5W0P7 Q5W0P8 Q658Z7 Q7Z481 Q8WWI2 Q9UG36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 EMDB 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9562621

Title: Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3.

PubMed ID: 9562621

DOI: 10.1093/oxfordjournals.jbchem.a022020

PubMed ID: 11935316

Title: A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes.

PubMed ID: 11935316

DOI: 10.1007/s00439-001-0646-6

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19056938

Title: RNA exosome depletion reveals transcription upstream of active human promoters.

PubMed ID: 19056938

DOI: 10.1126/science.1164096

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20531386

Title: The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.

PubMed ID: 20531386

DOI: 10.1038/emboj.2010.121

PubMed ID: 20531389

Title: Dis3-like 1: a novel exoribonuclease associated with the human exosome.

PubMed ID: 20531389

DOI: 10.1038/emboj.2010.122

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 29906447

Title: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.

PubMed ID: 29906447

DOI: 10.1016/j.cell.2018.05.041

Sequence Information:

  • Length: 958
  • Mass: 109003
  • Checksum: 92336BA0D06247FE
  • Sequence:
    • MLKSKTFLKK TRAGGVMKIV REHYLRDDIG CGAPGCAACG GAHEGPALEP QPQDPASSVC 
PQPHYLLPDT NVLLHQIDVL EDPAIRNVIV LQTVLQEVRN RSAPVYKRIR DVTNNQEKHF 
YTFTNEHHRE TYVEQEQGEN ANDRNDRAIR VAAKWYNEHL KKMSADNQLQ VIFITNDRRN 
KEKAIEEGIP AFTCEEYVKS LTANPELIDR LACLSEEGNE IESGKIIFSE HLPLSKLQQG 
IKSGTYLQGT FRASRENYLE ATVWIHGDNE ENKEIILQGL KHLNRAVHED IVAVELLPKS 
QWVAPSSVVL HDEGQNEEDV EKEEETERML KTAVSEKMLK PTGRVVGIIK RNWRPYCGML 
SKSDIKESRR HLFTPADKRI PRIRIETRQA STLEGRRIIV AIDGWPRNSR YPNGHFVRNL 
GDVGEKETET EVLLLEHDVP HQPFSQAVLS FLPKMPWSIT EKDMKNREDL RHLCICSVDP 
PGCTDIDDAL HCRELENGNL EVGVHIADVS HFIRPGNALD QESARRGTTV YLCEKRIDMV 
PELLSSNLCS LKCDVDRLAF SCIWEMNHNA EILKTKFTKS VINSKASLTY AEAQLRIDSA 
NMNDDITTSL RGLNKLAKIL KKRRIEKGAL TLSSPEVRFH MDSETHDPID LQTKELRETN 
SMVEEFMLLA NISVAKKIHE EFSEHALLRK HPAPPPSNYE ILVKAARSRN LEIKTDTAKS 
LAESLDQAES PTFPYLNTLL RILATRCMMQ AVYFCSGMDN DFHHYGLASP IYTHFTSPIR 
RYADVIVHRL LAVAIGADCT YPELTDKHKL ADICKNLNFR HKMAQYAQRA SVAFHTQLFF 
KSKGIVSEEA YILFVRKNAI VVLIPKYGLE GTVFFEEKDK PNPQLIYDDE IPSLKIEDTV 
FHVFDKVKVK IMLDSSNLQH QKIRMSLVEP QIPGISIPTD TSNMDLNGPK KKKMKLGK

Genular Protein ID: 577656020

Symbol: G3V1J5_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V1J5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 5 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 796
  • Mass: 90584
  • Checksum: 4DFB954BBFFD6EE1
  • Sequence:
    • MSADNQLQVI FITNDRRNKE KAIEEGIPAF TCEEYVKSLT ANPELIDRLA CLSEEGNEIE 
SGKIIFSEHL PLSKLQQGIK SGTYLQGTFR ASRENYLEAT VWIHGDNEEN KEIILQGLKH 
LNRAVHEDIV AVELLPKSQW VAPSSVVLHD EGQNEEDVEK EEETERMLKT AVSEKMLKPT 
GRVVGIIKRN WRPYCGMLSK SDIKESRRHL FTPADKRIPR IRIETRQAST LEGRRIIVAI 
DGWPRNSRYP NGHFVRNLGD VGEKETETEV LLLEHDVPHQ PFSQAVLSFL PKMPWSITEK 
DMKNREDLRH LCICSVDPPG CTDIDDALHC RELENGNLEV GVHIADVSHF IRPGNALDQE 
SARRGTTVYL CEKRIDMVPE LLSSNLCSLK CDVDRLAFSC IWEMNHNAEI LKTKFTKSVI 
NSKASLTYAE AQLRIDSANM NDDITTSLRG LNKLAKILKK RRIEKGALTL SSPEVRFHMD 
SETHDPIDLQ TKELRETNSM VEEFMLLANI SVAKKIHEEF SEHALLRKHP APPPSNYEIL 
VKAARSRNLE IKTDTAKSLA ESLDQAESPT FPYLNTLLRI LATRCMMQAV YFCSGMDNDF 
HHYGLASPIY THFTSPIRRY ADVIVHRLLA VAIGADCTYP ELTDKHKLAD ICKNLNFRHK 
MAQYAQRASV AFHTQLFFKS KGIVSEEAYI LFVRKNAIVV LIPKYGLEGT VFFEEKDKPN 
PQLIYDDEIP SLKIEDTVFH VFDKVKVKIM LDSSNLQHQK IRMSLVEPQI PGISIPTDTS 
NMDLNGPKKK KMKLGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.