Details for: RPH3A

Gene ID: 22895

Symbol: RPH3A

Ensembl ID: ENSG00000089169

Description: rabphilin 3A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30,404
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.72
    Marker Score: 40,644
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.68
    Marker Score: 20,516
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.47
    Marker Score: 1,106
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.45
    Marker Score: 8,213
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.37
    Marker Score: 47,195
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.11
    Marker Score: 19,802
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.8
    Marker Score: 66,545
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17,136
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.58
    Marker Score: 97,149
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.54
    Marker Score: 15,917
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.47
    Marker Score: 12,597
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.46
    Marker Score: 2,055
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.45
    Marker Score: 696
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.44
    Marker Score: 2,971
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.43
    Marker Score: 5,522
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.34
    Marker Score: 2,717
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2,058
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.3
    Marker Score: 2,466
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.3
    Marker Score: 5,281
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.29
    Marker Score: 672
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.19
    Marker Score: 45,009
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.03
    Marker Score: 2,951
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2,506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14,159
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 517
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.85
    Marker Score: 1,425
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.83
    Marker Score: 5,539
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.8
    Marker Score: 2,002
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 241
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.67
    Marker Score: 2,805
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.65
    Marker Score: 3,007
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 256
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.52
    Marker Score: 1,061
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.51
    Marker Score: 163
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.5
    Marker Score: 624
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.49
    Marker Score: 324
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.44
    Marker Score: 171
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 171
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 164
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.37
    Marker Score: 1,520
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.37
    Marker Score: 862
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 167
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.33
    Marker Score: 334
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.32
    Marker Score: 581
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.31
    Marker Score: 305
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.31
    Marker Score: 112
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.31
    Marker Score: 1,285
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.29
    Marker Score: 99
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3,859
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 251
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.28
    Marker Score: 668
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.26
    Marker Score: 14,606
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 228
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.24
    Marker Score: 144
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.22
    Marker Score: 255
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.22
    Marker Score: 89
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 265
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.21
    Marker Score: 64
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2
    Marker Score: 4,263
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.2
    Marker Score: 40
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 335
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.19
    Marker Score: 211
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.18
    Marker Score: 1,828
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.17
    Marker Score: 422
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.16
    Marker Score: 975
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.16
    Marker Score: 191
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.16
    Marker Score: 253

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPH3A's key characteristics include: 1. **Calcium-dependent phospholipid binding**: RPH3A interacts with calcium ions and phospholipids, regulating membrane trafficking and synaptic transmission. 2. **Exocytosis**: RPH3A is involved in the regulation of exocytosis, a process critical for neurotransmitter release and immune responses. 3. **Synaptic transmission**: RPH3A plays a crucial role in synaptic transmission, influencing the efficacy and plasticity of neuronal connections. 4. **Immune regulation**: RPH3A is expressed in immune cells, such as progenitor cells and dendritic cells, and is involved in regulating immune responses and inflammation. **Pathways and Functions** RPH3A's involvement in various cellular processes can be attributed to its interactions with multiple signaling pathways, including: 1. **Calcium-dependent phospholipid binding**: RPH3A binds to calcium ions and phospholipids, regulating membrane trafficking and synaptic transmission. 2. **Exocytosis**: RPH3A modulates exocytosis, influencing neurotransmitter release and immune responses. 3. **Inositol 1,4,5 trisphosphate (IP3) signaling**: RPH3A interacts with IP3, a key regulator of intracellular calcium levels. 4. **Phosphatidylinositol-4,5-bisphosphate (PIP2) signaling**: RPH3A binds to PIP2, a phospholipid involved in synaptic transmission and membrane trafficking. **Clinical Significance** RPH3A's dysregulation has been implicated in various neurological and immune disorders, including: 1. **Neurodegenerative diseases**: RPH3A's involvement in synaptic transmission and exocytosis suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune disorders**: RPH3A's expression in immune cells and its involvement in immune regulation imply its potential role in autoimmune diseases and inflammatory disorders. 3. **Cancer**: RPH3A's interaction with phospholipids and calcium ions suggests its potential role in cancer progression and metastasis. In conclusion, RPH3A is a complex protein with far-reaching implications in immune regulation and neurological function. Further research is necessary to elucidate the mechanisms underlying RPH3A's functions and its role in various diseases. As an expert immunologist, I emphasize the importance of understanding RPH3A's complexities to develop novel therapeutic strategies for neurological and immune disorders.

Genular Protein ID: 2934876966

Symbol: RP3A_HUMAN

Name: Rabphilin-3A

UniProtKB Accession Codes:

Q9Y2J0 B7Z3C3 Q96AE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 29 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 4 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15207266

Title: Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

PubMed ID: 15207266

DOI: 10.1016/j.nbd.2004.01.001

Sequence Information:

  • Length: 694
  • Mass: 76872
  • Checksum: BD9C43F306A04D69
  • Sequence:
    • MTDTVFSNSS NRWMYPSDRP LQSNDKEQLQ AGWSVHPGGQ PDRQRKQEEL TDEEKEIINR 
VIARAEKMEE MEQERIGRLV DRLENMRKNV AGDGVNRCIL CGEQLGMLGS ACVVCEDCKK 
NVCTKCGVET NNRLHSVWLC KICIEQREVW KRSGAWFFKG FPKQVLPQPM PIKKTKPQQP 
VSEPAAPEQP APEPKHPARA PARGDSEDRR GPGQKTGPDP ASAPGRGNYG PPVRRASEAR 
MSSSSRDSES WDHSGGAGDS SRSPAGLRRA NSVQASRPAP GSVQSPAPPQ PGQPGTPGGS 
RPGPGPAGRF PDQKPEVAPS DPGTTAPPRE ERTGGVGGYP AVGAREDRMS HPSGPYSQAS 
AAAPQPAAAR QPPPPEEEEE EANSYDSDEA TTLGALEFSL LYDQDNSSLQ CTIIKAKGLK 
PMDSNGLADP YVKLHLLPGA SKSNKLRTKT LRNTRNPIWN ETLVYHGITD EDMQRKTLRI 
SVCDEDKFGH NEFIGETRFS LKKLKPNQRK NFNICLERVI PMKRAGTTGS ARGMALYEEE 
QVERVGDIEE RGKILVSLMY STQQGGLIVG IIRCVHLAAM DANGYSDPFV KLWLKPDMGK 
KAKHKTQIKK KTLNPEFNEE FFYDIKHSDL AKKSLDISVW DYDIGKSNDY IGGCQLGISA 
KGERLKHWYE CLKNKDKKIE RWHQLQNENH VSSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.