Details for: CEP164

Gene ID: 22897

Symbol: CEP164

Ensembl ID: ENSG00000110274

Description: centrosomal protein 164

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.88
    Marker Score: 984
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.72
    Marker Score: 16,159
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.71
    Marker Score: 25,636
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11,804
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56,575
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.53
    Marker Score: 94,008
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6,037
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.46
    Marker Score: 29,022
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.45
    Marker Score: 30,920
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.43
    Marker Score: 5,531
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,548
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53,195
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,154
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11,693
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.35
    Marker Score: 1,810
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.32
    Marker Score: 13,620
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.28
    Marker Score: 1,546
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2
    Marker Score: 5,040
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.16
    Marker Score: 648
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.11
    Marker Score: 507
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.08
    Marker Score: 454
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.07
    Marker Score: 320
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.05
    Marker Score: 3,594
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.04
    Marker Score: 605
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.03
    Marker Score: 326
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.02
    Marker Score: 8,884
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,965
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.01
    Marker Score: 591
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.01
    Marker Score: 2,882
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,928
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.99
    Marker Score: 4,560
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.97
    Marker Score: 4,021
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.94
    Marker Score: 275
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.93
    Marker Score: 2,039
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.92
    Marker Score: 444
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2,121
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1,676
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.87
    Marker Score: 15,462
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.86
    Marker Score: 747
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.86
    Marker Score: 3,167
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,868
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1,381
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 265
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.84
    Marker Score: 634
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.81
    Marker Score: 221
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 862
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 859
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.77
    Marker Score: 889
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.77
    Marker Score: 848
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.76
    Marker Score: 793
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 239
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.74
    Marker Score: 1,774
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.74
    Marker Score: 2,471
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.73
    Marker Score: 8,244
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.73
    Marker Score: 881
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.73
    Marker Score: 899
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4,365
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.72
    Marker Score: 902
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.72
    Marker Score: 1,528
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.72
    Marker Score: 278
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.72
    Marker Score: 268
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.72
    Marker Score: 341
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,457
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.71
    Marker Score: 258
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,972
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.7
    Marker Score: 1,327
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7
    Marker Score: 237
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.69
    Marker Score: 255
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 887
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.68
    Marker Score: 274
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.67
    Marker Score: 23,303
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.65
    Marker Score: 316
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.65
    Marker Score: 4,162
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.64
    Marker Score: 590
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 381
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.63
    Marker Score: 289
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.63
    Marker Score: 414
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.63
    Marker Score: 349
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.62
    Marker Score: 250
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.61
    Marker Score: 229
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 859
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.6
    Marker Score: 244
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.6
    Marker Score: 569
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.59
    Marker Score: 697
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.59
    Marker Score: 307
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.59
    Marker Score: 207

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location and Function**: The CEP164 gene is localized on chromosome 1p36.33 and encodes a protein that is involved in the anchoring of the basal body to the plasma membrane, the activation of Aurka by Tpx2, and the regulation of the cell cycle. 2. **Cellular Expression**: The CEP164 protein is highly expressed in rod bipolar cells, GABAergic cortical interneurons, and astrocytes of the cerebral cortex, indicating its essential role in neurodevelopment and neuronal function. 3. **Pathway Involvement**: CEP164 is involved in various cellular pathways, including cell cycle regulation, centrosome maturation, ciliary assembly, and DNA repair. It also plays a role in the recruitment of mitotic centrosome proteins and complexes, ensuring proper chromosome segregation during mitosis. 4. **Interactions with Other Proteins**: The CEP164 protein interacts with other proteins, such as Aurora kinase A (Aurka) and NIMA-related kinase 2 (Numa), to regulate the cell cycle and centrosome maturation. **Pathways and Functions** 1. **Anchoring of the Basal Body to the Plasma Membrane**: CEP164 helps to anchor the basal body to the plasma membrane, ensuring proper ciliary assembly and function. 2. **Aurka Activation by Tpx2**: CEP164 activates Aurka by interacting with Tpx2, a protein kinase that regulates the activity of Aurka. 3. **Cell Cycle Regulation**: CEP164 plays a crucial role in the regulation of the cell cycle, particularly during the G2/M transition, ensuring proper chromosome segregation during mitosis. 4. **Centrosome Maturation**: CEP164 is involved in the maturation of centrosomes, ensuring proper centrosome function and organization. 5. **Ciliary Transition Fiber**: CEP164 regulates the assembly of ciliary transition fibers, ensuring proper ciliary function and assembly. 6. **DNA Repair**: CEP164 interacts with proteins involved in DNA repair, ensuring proper DNA replication and repair. **Clinical Significance** 1. **Neurodevelopmental Disorders**: Abnormal expression of CEP164 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Diseases**: CEP164 dysfunction has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: Aberrant expression of CEP164 has been observed in various types of cancer, suggesting its potential role in tumorigenesis. 4. **Ciliary Dysfunction**: CEP164 dysfunction can lead to ciliary dysfunction, resulting in diseases such as primary ciliary dyskinesia (PCD) and polycystic kidney disease (PKD). In conclusion, the CEP164 gene plays a crucial role in various cellular processes, including cell cycle regulation, centrosome maturation, and ciliary assembly. Its dysregulation has been implicated in neurodevelopmental disorders, neurodegenerative diseases, and cancer, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 1123717751

Symbol: CE164_HUMAN

Name: Centrosomal protein of 164 kDa

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 17954613

Title: Cep164, a novel centriole appendage protein required for primary cilium formation.

PubMed ID: 17954613

DOI: 10.1083/jcb.200707181

PubMed ID: 18283122

Title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

PubMed ID: 18283122

DOI: 10.1101/gad.1627708

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19197159

Title: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity.

PubMed ID: 19197159

DOI: 10.4161/cc.8.4.7844

PubMed ID: 21976302

Title: Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy.

PubMed ID: 21976302

DOI: 10.1002/cm.20536

PubMed ID: 22863007

Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

PubMed ID: 22863007

DOI: 10.1016/j.cell.2012.06.028

PubMed ID: 23348840

Title: Centriole distal appendages promote membrane docking, leading to cilia initiation.

PubMed ID: 23348840

DOI: 10.1101/gad.207043.112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23530209

Title: CCDC41 is required for ciliary vesicle docking to the mother centriole.

PubMed ID: 23530209

DOI: 10.1073/pnas.1220927110

PubMed ID: 26337392

Title: MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

PubMed ID: 26337392

DOI: 10.1091/mbc.e15-04-0235

Sequence Information:

  • Length: 1460
  • Mass: 164314
  • Checksum: 7A4F91E1CB7D1E43
  • Sequence:
  • MAGRPLRIGD QLVLEEDYDE TYIPSEQEIL EFAREIGIDP IKEPELMWLA REGIVAPLPG 
    EWKPCQDITG DIYYFNFANG QSMWDHPCDE HYRSLVIQER AKLSTSGAIK KKKKKKEKKD 
    KKDRDPPKSS LALGSSLAPV HVPLGGLAPL RGLVDTPPSA LRGSQSVSLG SSVESGRQLG 
    ELMLPSQGLK TSAYTKGLLG SIYEDKTALS LLGLGEETNE EDEEESDNQS VHSSSEPLRN 
    LHLDIGALGG DFEYEESLRT SQPEEKKDVS LDSDAAGPPT PCKPSSPGAD SSLSSAVGKG 
    RQGSGARPGL PEKEENEKSE PKICRNLVTP KADPTGSEPA KASEKEAPED TVDAGEEGSR 
    REEAAKEPKK KASALEEGSS DASQELEISE HMKEPQLSDS IASDPKSFHG LDFGFRSRIS 
    EHLLDVDVLS PVLGGACRQA QQPLGIEDKD DSQSSQDELQ SKQSKGLEER LSPPLPHEER 
    AQSPPRSLAT EEEPPQGPEG QPEWKEAEEL GEDSAASLSL QLSLQREQAP SPPAACEKGK 
    EQHSQAEELG PGQEEAEDPE EKVAVSPTPP VSPEVRSTEP VAPPEQLSEA ALKAMEEAVA 
    QVLEQDQRHL LESKQEKMQQ LREKLCQEEE EEILRLHQQK EQSLSSLRER LQKAIEEEEA 
    RMREEESQRL SWLRAQVQSS TQADEDQIRA EQEASLQKLR EELESQQKAE RASLEQKNRQ 
    MLEQLKEEIE ASEKSEQAAL NAAKEKALQQ LREQLEGERK EAVATLEKEH SAELERLCSS 
    LEAKHREVVS SLQKKIQEAQ QKEEAQLQKC LGQVEHRVHQ KSYHVAGYEH ELSSLLREKR 
    QEVEGEHERR LDKMKEEHQQ VMAKAREQYE AEERKQRAEL LGHLTGELER LQRAHERELE 
    TVRQEQHKRL EDLRRRHREQ ERKLQDLELD LETRAKDVKA RLALLEVQEE TARREKQQLL 
    DVQRQVALKS EEATATHQQL EEAQKEHTHL LQSNQQLREI LDELQARKLK LESQVDLLQA 
    QSQQLQKHFS SLEAEAQKKQ HLLREVTVEE NNASPHFEPD LHIEDLRKSL GTNQTKEVSS 
    SLSQSKEDLY LDSLSSHNVW HLLSAEGVAL RSAKEFLVQQ TRSMRRRQTA LKAAQQHWRH 
    ELASAQEVAK DPPGIKALED MRKNLEKETR HLDEMKSAMR KGHNLLKKKE EKLNQLESSL 
    WEEASDEGTL GGSPTKKAVT FDLSDMDSLS SESSESFSPP HREWWRQQRI DSTPSLTSRK 
    IHGLSHSLRQ ISSQLSSVLS ILDSLNPQSP PPLLASMPAQ LPPRDPKSTP TPTYYGSLAR 
    FSALSSATPT STQWAWDSGQ GPRLPSSVAQ TVDDFLLEKW RKYFPSGIPL LSNSPTPLES 
    RLGYMSASEQ LRLLQHSHSQ VPEAGSTTFQ GIIEANRRWL ERVKNDPRLP LFSSTPKPKA 
    TLSLLQLGLD EHNRVKVYRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.