Details for: DENND3

Gene ID: 22898

Symbol: DENND3

Ensembl ID: ENSG00000105339

Description: DENN domain containing 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.45
    Marker Score: 886
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.25
    Marker Score: 2,714
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.06
    Marker Score: 1,026
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.96
    Marker Score: 1,169
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.88
    Marker Score: 589
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.7
    Marker Score: 1,958
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15,362
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.46
    Marker Score: 89,538
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2,243
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.45
    Marker Score: 785
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.45
    Marker Score: 12,416
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.41
    Marker Score: 453
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.38
    Marker Score: 12,952
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.34
    Marker Score: 13,840
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,236
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.26
    Marker Score: 2,289
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.22
    Marker Score: 513
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.22
    Marker Score: 546
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 705
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.17
    Marker Score: 65,151
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.09
    Marker Score: 1,043
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Marker Score: 17,244
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.05
    Marker Score: 2,050
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.01
    Marker Score: 10,271
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2,347
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,967
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.98
    Marker Score: 2,430
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.97
    Marker Score: 970
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.97
    Marker Score: 4,053
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.93
    Marker Score: 2,254
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.93
    Marker Score: 700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,952
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.87
    Marker Score: 225
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,253
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.86
    Marker Score: 864
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.83
    Marker Score: 745
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.83
    Marker Score: 2,475
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3,297
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.8
    Marker Score: 916
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.8
    Marker Score: 202
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.79
    Marker Score: 1,068
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.78
    Marker Score: 1,140
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 845
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.77
    Marker Score: 188
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.77
    Marker Score: 4,989
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,240
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 303
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.75
    Marker Score: 739
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.74
    Marker Score: 364
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.74
    Marker Score: 3,066
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,028
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.71
    Marker Score: 165
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.71
    Marker Score: 349
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.69
    Marker Score: 1,751
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.69
    Marker Score: 436
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.68
    Marker Score: 198
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 450
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.67
    Marker Score: 632
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 736
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.65
    Marker Score: 665
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.65
    Marker Score: 224
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.63
    Marker Score: 147
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.62
    Marker Score: 212
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 994
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.62
    Marker Score: 553
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.62
    Marker Score: 745
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.59
    Marker Score: 246
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.59
    Marker Score: 357
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 387
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.58
    Marker Score: 2,415
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.58
    Marker Score: 249
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.57
    Marker Score: 1,586
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.57
    Marker Score: 391
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.57
    Marker Score: 633
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.56
    Marker Score: 195
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.56
    Marker Score: 1,456
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.56
    Marker Score: 4,266
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.56
    Marker Score: 478
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.55
    Marker Score: 584
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.55
    Marker Score: 1,261
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.55
    Marker Score: 593
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.54
    Marker Score: 904
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.54
    Marker Score: 266

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DENND3 is a member of the DENN domain-containing protein family, characterized by its unique DENN domain, which is responsible for its interaction with Rab GTPases. The DENN domain is a conserved motif that has been implicated in the regulation of membrane trafficking and protein catabolism. DENND3 is primarily expressed in cells of the immune system, including macrophages, microglial cells, and endothelial cells, suggesting its role in immune surveillance and tissue homeostasis. Its expression is also observed in neurons, particularly in glutamatergic cortical neurons, highlighting its potential involvement in neurological functions. **Pathways and Functions:** DENND3 has been implicated in various cellular processes, including: 1. **Membrane Trafficking:** DENND3 interacts with Rab GTPases, regulating membrane trafficking and vesicle-mediated transport. This interaction is essential for the proper functioning of immune cells and endothelial cells. 2. **Protein Catabolism:** DENND3 has been shown to participate in protein degradation pathways, regulating the turnover of proteins involved in immune responses. 3. **Rab Regulation of Trafficking:** DENND3 modulates the activity of Rab GTPases, influencing the regulation of membrane trafficking and vesicle-mediated transport. 4. **Guanyl-nucleotide Exchange Factor Activity:** DENND3 has been implicated in the regulation of guanyl-nucleotide exchange factors, which are essential for the activation of small GTPases. **Clinical Significance:** DENND3 has been identified as a gene of interest in various disease models, including: 1. **Neurological Disorders:** DENND3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. Mutations in DENND3 have been associated with an increased risk of developing these diseases. 2. **Immune-Mediated Disorders:** DENND3 has been shown to play a crucial role in immune surveillance, and its dysregulation has been implicated in immune-mediated disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** DENND3 has been identified as a tumor suppressor gene, and its dysregulation has been implicated in the development of various types of cancer. In conclusion, DENND3 is a complex gene that plays a multifaceted role in immune responses and cellular trafficking. Its dysregulation has been implicated in various disease models, highlighting the need for further research into the mechanisms underlying DENND3 function. Further studies are necessary to fully elucidate the clinical significance of DENND3 and its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2431660366

Symbol: DEND3_HUMAN

Name: DENN domain-containing protein 3

UniProtKB Accession Codes:

A2RUS2 B7ZM28 O94947 Q2TAM7 Q6ZMS6 Q96DK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 20937701

Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

PubMed ID: 20937701

DOI: 10.1083/jcb.201008051

Sequence Information:

  • Length: 1198
  • Mass: 135890
  • Checksum: 52D51635DDD88A4E
  • Sequence:
    • MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL TLPQLCFPGG VCVATEPKED 
CVHFLVLTDV CGNRTYGVVA QYYRPLHDEY CFYNGKTHRE CPGCFVPFAV CVVSRFPYYN 
SLKDCLSCLL ALLKPCKDFE VDSHIKDFAA KLSLIPSPPP GPLHLVFNMK SLQIVLPARA 
DPESPILDLD LHLPLLCFRP EKVLQILTCI LTEQRIVFFS SDWALLTLVT ECFMAYLYPL 
QWQHPFVPIL SDQMLDFVMA PTSFLMGCHL DHFEEVSKEA DGLVLINIDH GSITYSKSTD 
DNVDIPDVPL LAAQTFIQRV QSLQLHHELH AAHLLSSTDL KEGRAHRRSW QQKLNCQIQQ 
TTLQLLVSIF RDVKNHLNYE HRVFNSEEFL KTRAPGDHQF YKQVLDTYMF HSFLKARLNR 
RMDAFAQMDL DTQSEEDRIN GMLLSPRRPT VEKRASRKSS HLHVTHRRMV VSMPNLQDIA 
MPELAPRNSS LRLTDTAGCR GSSAVLNVTP KSPYTFKIPE IHFPLESKCV QAYHAHFVSM 
LSEAMCFLAP DNSLLLARYL YLRGLVYLMQ GQLLNALLDF QNLYKTDIRI FPTDLVKRTV 
ESMSAPEWEG AEQAPELMRL ISEILDKPHE ASKLDDHVKK FKLPKKHMQL GDFMKRVQES 
GIVKDASIIH RLFEALTVGQ EKQIDPETFK DFYNCWKETE AEAQEVSLPW LVMEHLDKNE 
CVCKLSSSVK TNLGVGKIAM TQKRLFLLTE GRPGYLEIST FRNIEEVRRT TTTFLLRRIP 
TLKIRVASKK EVFEANLKTE CDLWHLMVKE MWAGKKLADD HKDPHYVQQA LTNVLLMDAV 
VGTLQSPGAI YAASKLSYFD KMSNEMPMTL PETTLETLKH KINPSAGEAF PQAVDVLLYT 
PGHLDPAEKV EDAHPKLWCA LSEGKVTVFN ASSWTIHQHS FKVGTAKVNC MVMADQNQVW 
VGSEDSVIYI INVHSMSCNK QLTAHCSSVT DLIVQDGQEA PSNVYSCSMD GMVLVWNVST 
LQVTSRFQLP RGGLTSIRLH GGRLWCCTGN SIMVMKMNGS LHQELKIEEN FKDTSTSFLA 
FQLLPEEEQL WAACAGRSEV YIWSLKDLAQ PPQRVPLEDC SEINCMIRVK KQVWVGSRGL 
GQGTPKGKIY VIDAERKTVE KELVAHMDTV RTLCSAEDRY VLSGSGREEG KVAIWKGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.