Details for: DENND3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.45
Marker Score: 886 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.25
Marker Score: 2,714 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.06
Marker Score: 1,026 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.96
Marker Score: 1,169 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.88
Marker Score: 589 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.7
Marker Score: 1,958 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.62
Marker Score: 15,362 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.46
Marker Score: 89,538 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.45
Marker Score: 2,243 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.45
Marker Score: 785 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.45
Marker Score: 12,416 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.41
Marker Score: 453 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.38
Marker Score: 12,952 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.34
Marker Score: 13,840 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20,236 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.26
Marker Score: 2,289 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.22
Marker Score: 513 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.22
Marker Score: 546 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.17
Marker Score: 705 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.17
Marker Score: 65,151 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.09
Marker Score: 1,043 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.07
Marker Score: 17,244 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.05
Marker Score: 2,050 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.01
Marker Score: 10,271 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,743 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1
Marker Score: 2,347 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,967 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,398 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.98
Marker Score: 2,430 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.97
Marker Score: 970 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.97
Marker Score: 4,053 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.95
Marker Score: 452 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,405 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 442 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.93
Marker Score: 2,254 - Cell Name: memory B cell (CL0000787)
Fold Change: 0.93
Marker Score: 700 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,718 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.89
Marker Score: 244 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,952 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.87
Marker Score: 225 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,253 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.86
Marker Score: 864 - Cell Name: naive B cell (CL0000788)
Fold Change: 0.83
Marker Score: 745 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.83
Marker Score: 2,475 - Cell Name: neuron (CL0000540)
Fold Change: 0.81
Marker Score: 3,297 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.8
Marker Score: 916 - Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.8
Marker Score: 202 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.79
Marker Score: 1,068 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.78
Marker Score: 1,140 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.78
Marker Score: 845 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.78
Marker Score: 431 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.77
Marker Score: 188 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.77
Marker Score: 4,989 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1,240 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 303 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.75
Marker Score: 739 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.74
Marker Score: 364 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.74
Marker Score: 3,066 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 379 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3,028 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.71
Marker Score: 165 - Cell Name: centroblast (CL0009112)
Fold Change: 0.71
Marker Score: 349 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.69
Marker Score: 1,751 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.69
Marker Score: 436 - Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 624 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.68
Marker Score: 198 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.68
Marker Score: 450 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.67
Marker Score: 632 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.67
Marker Score: 736 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.65
Marker Score: 665 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.65
Marker Score: 224 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.64
Marker Score: 383 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.63
Marker Score: 147 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.62
Marker Score: 212 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.62
Marker Score: 994 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.62
Marker Score: 553 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.62
Marker Score: 745 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.59
Marker Score: 246 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.59
Marker Score: 357 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.59
Marker Score: 387 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.58
Marker Score: 2,415 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.58
Marker Score: 249 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.57
Marker Score: 1,586 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.57
Marker Score: 391 - Cell Name: macrophage (CL0000235)
Fold Change: 0.57
Marker Score: 633 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.56
Marker Score: 195 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.56
Marker Score: 1,456 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.56
Marker Score: 4,266 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.56
Marker Score: 478 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.55
Marker Score: 584 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.55
Marker Score: 1,261 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.55
Marker Score: 159 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.55
Marker Score: 593 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 432 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.54
Marker Score: 904 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.54
Marker Score: 266
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2431660366
Symbol: DEND3_HUMAN
Name: DENN domain-containing protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 20937701
Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
PubMed ID: 20937701
Sequence Information:
- Length: 1198
- Mass: 135890
- Checksum: 52D51635DDD88A4E
- Sequence:
MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL TLPQLCFPGG VCVATEPKED CVHFLVLTDV CGNRTYGVVA QYYRPLHDEY CFYNGKTHRE CPGCFVPFAV CVVSRFPYYN SLKDCLSCLL ALLKPCKDFE VDSHIKDFAA KLSLIPSPPP GPLHLVFNMK SLQIVLPARA DPESPILDLD LHLPLLCFRP EKVLQILTCI LTEQRIVFFS SDWALLTLVT ECFMAYLYPL QWQHPFVPIL SDQMLDFVMA PTSFLMGCHL DHFEEVSKEA DGLVLINIDH GSITYSKSTD DNVDIPDVPL LAAQTFIQRV QSLQLHHELH AAHLLSSTDL KEGRAHRRSW QQKLNCQIQQ TTLQLLVSIF RDVKNHLNYE HRVFNSEEFL KTRAPGDHQF YKQVLDTYMF HSFLKARLNR RMDAFAQMDL DTQSEEDRIN GMLLSPRRPT VEKRASRKSS HLHVTHRRMV VSMPNLQDIA MPELAPRNSS LRLTDTAGCR GSSAVLNVTP KSPYTFKIPE IHFPLESKCV QAYHAHFVSM LSEAMCFLAP DNSLLLARYL YLRGLVYLMQ GQLLNALLDF QNLYKTDIRI FPTDLVKRTV ESMSAPEWEG AEQAPELMRL ISEILDKPHE ASKLDDHVKK FKLPKKHMQL GDFMKRVQES GIVKDASIIH RLFEALTVGQ EKQIDPETFK DFYNCWKETE AEAQEVSLPW LVMEHLDKNE CVCKLSSSVK TNLGVGKIAM TQKRLFLLTE GRPGYLEIST FRNIEEVRRT TTTFLLRRIP TLKIRVASKK EVFEANLKTE CDLWHLMVKE MWAGKKLADD HKDPHYVQQA LTNVLLMDAV VGTLQSPGAI YAASKLSYFD KMSNEMPMTL PETTLETLKH KINPSAGEAF PQAVDVLLYT PGHLDPAEKV EDAHPKLWCA LSEGKVTVFN ASSWTIHQHS FKVGTAKVNC MVMADQNQVW VGSEDSVIYI INVHSMSCNK QLTAHCSSVT DLIVQDGQEA PSNVYSCSMD GMVLVWNVST LQVTSRFQLP RGGLTSIRLH GGRLWCCTGN SIMVMKMNGS LHQELKIEEN FKDTSTSFLA FQLLPEEEQL WAACAGRSEV YIWSLKDLAQ PPQRVPLEDC SEINCMIRVK KQVWVGSRGL GQGTPKGKIY VIDAERKTVE KELVAHMDTV RTLCSAEDRY VLSGSGREEG KVAIWKGE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.